Serious limitations of the QTL/microarray approach for QTL gene discovery (Q30435134)

14 October 2017

Serious limitations of the QTL/microarray approach for QTL gene discovery (English)

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14 October 2017

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Charles R Farber

2

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Juan F Medrano

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Juan F Medrano

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14 October 2017

Ricardo A Verdugo

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1 reference

14 October 2017

Craig H Warden

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14 October 2017

language of work or name

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12 July 2010

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14 October 2017

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14 October 2017

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14 October 2017

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describes a project that uses

14 October 2017

affy

object named as

affy

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

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Transcriptional profiling of chromosome 17 quantitative trait Loci for carbohydrate and total calorie intake in a mouse congenic strain reveals candidate genes and pathways

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A customized and versatile high-density genotyping array for the mouse.

20 June 2018

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GWAS meets microarray: are the results of genome-wide association studies and gene-expression profiling consistent? Prostate cancer as an example

20 June 2018

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Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents

20 June 2018

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The genetics of quantitative traits: challenges and prospects

20 June 2018

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FitSNPs: highly differentially expressed genes are more likely to have variants associated with disease

20 June 2018

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Randomization in laboratory procedure is key to obtaining reproducible microarray results

20 June 2018

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Revealing the architecture of gene regulation: the promise of eQTL studies

20 June 2018

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A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan Amazighs.

20 June 2018

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Efficient control of population structure in model organism association mapping

20 June 2018

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An imputed genotype resource for the laboratory mouse

20 June 2018

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A genome-wide association study of global gene expression

20 June 2018

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Population genomics of human gene expression

20 June 2018

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Candidate genes controlling pulmonary function in mice: transcript profiling and predicted protein structure.

20 June 2018

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A systematic strategy for large-scale analysis of genotype phenotype correlations: identification of candidate genes involved in African trypanosomiasis

20 June 2018

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Sequence polymorphisms cause many false cis eQTLs

20 June 2018

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Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains

20 June 2018

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An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes

20 June 2018

1 reference

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Genomewide association analysis in diverse inbred mice: power and population structure

20 June 2018

1 reference

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The nonsense-mediated decay RNA surveillance pathway

20 June 2018

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The evolutionary significance of cis-regulatory mutations

20 June 2018

1 reference

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Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritis

20 June 2018

1 reference

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Global eQTL mapping reveals the complex genetic architecture of transcript-level variation in Arabidopsis

20 June 2018

1 reference

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Fine mapping reveals sex bias in quantitative trait loci affecting growth, skeletal size and obesity-related traits on mouse chromosomes 2 and 11.

20 June 2018

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A high-resolution single nucleotide polymorphism genetic map of the mouse genome

20 June 2018

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Cis-regulatory variations: a study of SNPs around genes showing cis-linkage in segregating mouse populations

20 June 2018

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Integrating genetic and network analysis to characterize genes related to mouse weight

20 June 2018

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Integrating genetic and gene expression data: application to cardiovascular and metabolic traits in mice

20 June 2018

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Cd14, Gbp1, and Pla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses

20 June 2018

1 reference

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Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains

20 June 2018

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Comparison of gene coverage of mouse oligonucleotide microarray platforms

20 June 2018

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Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs.

20 June 2018

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Complex genetics of interactions of alcohol and CNS function and behavior

20 June 2018

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Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits

20 June 2018

1 reference

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RESOURCERER: a database for annotating and linking microarray resources within and across species

20 June 2018

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A statistical multiprobe model for analyzing cis and trans genes in genetical genomics experiments with short-oligonucleotide arrays

20 June 2018

1 reference

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Gene expression profiling of the left ventricles in a rat model of intrinsic aerobic running capacity

20 June 2018

1 reference

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Genetical genomics in humans and model organisms

20 June 2018

1 reference

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Cis-acting expression quantitative trait loci in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

The genetic dissection of immune response using gene-expression studies and genome mapping

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

The landscape of genetic complexity across 5,700 gene expression traits in yeast

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Improved statistical tests for differential gene expression by shrinking variance components estimates.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Quantitative genomics: exploring the genetic architecture of complex trait predisposition

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Genetic analysis of genome-wide variation in human gene expression

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

The Ensembl automatic gene annotation system

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

In silico study of transcriptome genetic variation in outbred populations

20 June 2018

1 reference

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Obesity in BSB mice is correlated with expression of genes for iron homeostasis and leptin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Quantitative genetic variation: a post-modern view

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Regulation of bone mass in mice by the lipoxygenase gene Alox15

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Genetic susceptibility to nickel-induced acute lung injury

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Genetics of gene expression surveyed in maize, mouse and man

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Quantitative trait loci affecting initial sensitivity and acute functional tolerance to ethanol-induced ataxia and brain cAMP signaling in BXD recombinant inbred mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Gene expression between a congenic strain that contains a quantitative trait locus of high bone density from CAST/EiJ and its wild-type strain C57BL/6J.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

BLAT—The BLAST-Like Alignment Tool

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Genetic dissection of transcriptional regulation in budding yeast

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: the NOD model of type 1 diabetes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Linkage disequilibrium in humans: models and data

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Lack of Socs2 expression causes the high-growth phenotype in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Association study designs for complex diseases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Quantitative trait loci mapping for cholesterol gallstones in AKR/J and C57L/J strains of mice.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Mapping a disease locus by allelic association

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Dissection of a genetically complex cluster of growth and obesity QTLs on mouse chromosome 2 using subcongenic intercrosses

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

A sequence-based variation map of 8.27 million SNPs in inbred mouse strains

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Identification of positional candidate genes for body weight and adiposity in subcongenic mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Differentially expressed genes in adipose tissues of high body weight-selected (obese) and unselected (lean) mouse lines

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Combined application of behavior genetics and microarray analysis to identify regional expression themes and gene-behavior associations.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Isolation and confirmation of a calcium excretion quantitative trait locus on chromosome 1 in genetic hypercalciuric stone-forming congenic rats

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Two new behavioral QTLs, Emo4 and Reb1, map to mouse Chromosome 1: Congenic strains and candidate gene identification studies

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Gene expression profiling of arthritis using a QTL chip reveals a complex gene regulation of the Cia5 region in mice.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Identification of hypertension-related genes through an integrated genomic-transcriptomic approach

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Locating a blood pressure quantitative trait locus within 117 kb on the rat genome: substitution mapping and renal expression analysis.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Microarray gene expression analysis of the Fob3b obesity QTL identifies positional candidate gene Sqle and perturbed cholesterol and glycolysis pathways

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

The Collaborative Cross, a community resource for the genetic analysis of complex traits

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Genetic regulation of endotoxin-induced airway disease

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Microarray analysis of hepatic gene expression in gallstone-susceptible and gallstone-resistant mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Use of a panel of congenic strains to evaluate differentially expressed genes as candidate genes for blood pressure quantitative trait loci

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Microarray analysis of rat chromosome 2 congenic strains

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Genetic dissection of quantitative trait loci specifying sedative/hypnotic sensitivity to ethanol: mapping with interval-specific congenic recombinant lines

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Confirmation and fine mapping of chromosomal regions influencing peak bone mass in mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Genetical genomics: the added value from segregation

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Salt Susceptibility Maps to Chromosomes 1 and 17 With Sex Specificity in the Sabra Rat Model of Hypertension

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Genetical genomics in livestock: potentials and pitfalls

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

Marker-assisted introgression of Trypanotolerance QTL in mice

26 November 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919467

26 November 2018

12 December 2020

Localization of a blood pressure QTL to a 2.4-cM interval on rat chromosome 9 using congenic strains

1 reference

12 December 2020

Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors

1 reference

12 December 2020

Multiple linked mouse chromosome 7 loci influence body fat mass

1 reference

12 December 2020

Combining congenic coverage with gene profiling in search of candidates for blood pressure quantitative trait loci in Dahl rats

1 reference

12 December 2020

The American Association for Accreditation of Laboratory Animal Care

1 reference

12 December 2020

Evidence for a major gene for rapid postweaning growth in mice

1 reference

12 December 2020

Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat

1 reference

12 December 2020

Quantitative trait loci for steady-state platelet count in mice

1 reference

12 December 2020

Transcriptional profiling with a blood pressure QTL interval-specific oligonucleotide array

1 reference

12 December 2020

Fine mapping of collagen-induced arthritis quantitative trait loci in an advanced intercross line

1 reference

12 December 2020

The monocyte chemotactic protein-1 gene may contribute to hypertension in Dahl salt-sensitive rats

1 reference

12 December 2020

Exclusion of the catechol-o-methyltransferase gene from genes contributing to salt-sensitive hypertension in dahl salt-sensitive rats

1 reference

12 December 2020

On the subspecific origin of the laboratory mouse

1 reference

12 December 2020

Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice

1 reference

12 December 2020

Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma

1 reference

12 December 2020

An integrative approach for the identification of quantitative trait loci

1 reference

12 December 2020

A genome scan for Loci associated with aerobic running capacity in rats

1 reference

12 December 2020

A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover

1 reference

12 December 2020

Genetics of colitis susceptibility in IL-10-deficient mice: backcross versus F2 results contrasted by principal component analysis

1 reference

12 December 2020

Identifiers

DOI

10.1186/1741-7007-8-96

1 reference

Dimensions Publication ID

14 October 2017

0 references

1 reference

14 October 2017

PubMed publication ID

20624276

1 reference