Gene therapy for deafness (Q30434063)

15 October 2017

Gene therapy for deafness (English)

1 reference

15 October 2017

0 references

1 reference

D C Kohrman

1

1 reference

PMC publication ID

4113964

15 October 2017

Y Raphael

series ordinal

2

1 reference

15 October 2017

18 July 2013

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15 October 2017

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15 October 2017

20

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15 October 2017

12

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15 October 2017

1119-1123

1 reference

Diaphanous homolog 3 (Diap3) overexpression causes progressive hearing loss and inner hair cell defects in a transgenic mouse model of human deafness

15 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

siRNA targeting Hes5 augments hair cell regeneration in aminoglycoside-damaged mouse utricle

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Magnetic targeted delivery of dexamethasone acetate across the round window membrane in guinea pigs

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Molecular mechanisms of inner ear development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Gene transfer in inner ear cells: a challenging race

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Hearing impairment: a panoply of genes and functions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Increased activity of Diaphanous homolog 3 (DIAPH3)/diaphanous causes hearing defects in humans with auditory neuropathy and in Drosophila

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Effects of localized neurotrophin gene expression on spiral ganglion neuron resprouting in the deafened cochlea

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Transtympanic administration of short interfering (si)RNA for the NOX3 isoform of NADPH oxidase protects against cisplatin-induced hearing loss in the rat.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Transgenic BDNF induces nerve fiber regrowth into the auditory epithelium in deaf cochleae

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Hearing loss: mechanisms revealed by genetics and cell biology

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Gene therapy in the inner ear using adenovirus vectors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Gene transfer using bovine adeno-associated virus in the guinea pig cochlea

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Mechanisms and genes in human strial presbycusis from animal models

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Cochlear implants: current designs and future possibilities

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Response of the flat cochlear epithelium to forced expression of Atoh1.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Manipulating cell cycle regulation in the mature cochlea

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

The fate of outer hair cells after acoustic or ototoxic insults

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

In vivo delivery of recombinant viruses to the fetal murine cochlea: transduction characteristics and long-term effects on auditory function

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Pathologic changes of presbycusis begin in secondary processes and spread to primary processes of strial marginal cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Resprouting and survival of guinea pig cochlear neurons in response to the administration of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Loss of KCNJ10 protein expression abolishes endocochlear potential and causes deafness in Pendred syndrome mouse model

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Localization and functional studies of pendrin in the mouse inner ear provide insight about the etiology of deafness in pendred syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo

20 June 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

20 June 2018

inferred from DOI database lookup

7 January 2021

based on heuristic

Hearing and hair cells are protected by adenoviral gene therapy with TGF-β1 and GDNF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Molecular genetics of mucopolysaccharidosis type IIIA and IIIB: Diagnostic, clinical, and biological implications

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Developmental expression patterns of connexin26 and -30 in the rat cochlea

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Hair cell protection from aminoglycoside ototoxicity by adenovirus-mediated overexpression of glial cell line-derived neurotrophic factor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Expression of the gap-junction connexins 26 and 30 in the rat cochlea

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Gap junctions in the rat cochlea: immunohistochemical and ultrastructural analysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Reorganization of cytoskeletal and junctional proteins during cochlear hair cell degeneration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

Morphological and physiological effects of long duration infusion of strychnine into the organ of Corti

20 June 2018

1 reference

In vitro and in vivo suppression of GJB2 expression by RNA interference.

21 January 2018

1 reference

Antioxidant gene therapy can protect hearing and hair cells from ototoxicity

21 January 2018

1 reference

Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea

21 January 2018

1 reference

Bcl-2 gene therapy prevents aminoglycoside-induced degeneration of auditory and vestibular hair cells.

21 January 2018

1 reference

Geranylgeranylacetone, a heat shock protein inducer, prevents acoustic injury in the guinea pig.

21 January 2018

1 reference

The chicken RaxL gene plays a role in the initiation of photoreceptor differentiation

21 January 2018

1 reference

Vestibular hair cell regeneration and restoration of balance function induced by math1 gene transfer

21 January 2018

1 reference

Pharmacological inhibition of Notch signaling in the mature guinea pig cochlea

21 January 2018

1 reference

p27(Kip1) deficiency causes organ of Corti pathology and hearing loss

21 January 2018

1 reference

Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein

21 January 2018

1 reference

Noninvasive in vivo delivery of transgene via adeno-associated virus into supporting cells of the neonatal mouse cochlea

21 January 2018

1 reference

Helper-dependent adenovirus-mediated gene transfer into the adult mouse cochlea

21 January 2018

1 reference

Gene transfer into the mammalian inner ear using HSV-1 and vaccinia virus vectors

21 January 2018

1 reference

HSV amplicon-mediated neurotrophin-3 expression protects murine spiral ganglion neurons from cisplatin-induced damage

21 January 2018

1 reference

Drug delivery to the cochlea using PLGA nanoparticles

21 January 2018

1 reference

Distribution of PLGA nanoparticles in chinchilla cochleae

21 January 2018

1 reference

Minimally invasive drug delivery to the cochlea through application of nanoparticles to the round window membrane.

21 January 2018

1 reference

Gene therapy for the inner ear

21 January 2018

1 reference

Disease correction by combined neonatal intracranial AAV and systemic lentiviral gene therapy in Sanfilippo Syndrome type B mice.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4113964

26 November 2018

Cochlear gene therapy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23864018

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/GT.2013.39

1 reference

15 October 2017

1 reference

PMC publication ID

4113964

15 October 2017

PubMed publication ID

23864018

1 reference

PMC publication ID

4113964