NMR and protein structure in drug design: application to cyclotides and conotoxins (Q30399297)

21 June 2017

1 reference

title

NMR and protein structure in drug design: application to cyclotides and conotoxins (English)

1 reference

21 June 2017

0 references

Sónia Troeira Henriques

Sónia Troeira Henriques

3

0 references

Norelle L Daly

Norelle L Daly

1

0 references

David Craik

David J Craik

4

0 references

K. Johan Rosengren

2

K Johan Rosengren

1 reference

21 June 2017

publication date

3 February 2011

1 reference

European Biophysics Journal

21 June 2017

published in

1 reference

21 June 2017

volume

40

1 reference

21 June 2017

issue

4

1 reference

21 June 2017

page(s)

359-370

1 reference

Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae

21 June 2017

cites work

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Drugs from slugs--past, present and future perspectives of omega-conotoxin research

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

A novel anti-HIV macrocyclic peptide from Palicourea condensata

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Biosynthesis of a fully functional cyclotide inside living bacterial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

A new alpha-conotoxin which targets alpha3beta2 nicotinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Isolation and characterization of novel cyclotides from Viola hederaceae: solution structure and anti-HIV activity of vhl-1, a leaf-specific expressed cyclotide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: the importance of the cyclic cystine knot.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

The anthelmintic activity of the cyclotides: natural variants with enhanced activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Chemistry. Seamless proteins tie up their loose ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Chemical modification of conotoxins to improve stability and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

NMR as a tool for elucidating the structures of circular and knotted proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Structures of naturally occurring circular proteins from bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

The cyclotide family of circular miniproteins: nature's combinatorial peptide template.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Structural studies of conotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Chemical synthesis and folding pathways of large cyclic polypeptides: studies of the cystine knot polypeptide kalata B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Retrocyclin-2: structural analysis of a potent anti-HIV theta-defensin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Discovery, structure and biological activities of cyclotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

alpha-Conotoxins: nicotinic acetylcholine receptor antagonists as pharmacological tools and potential drug leads

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Circular proteins in plants: solution structure of a novel macrocyclic trypsin inhibitor from Momordica cochinchinensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Disulfide mapping of the cyclotide kalata B1. Chemical proof of the cystic cystine knot motif.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Novel strategies for isolation and characterization of cyclotides: the discovery of bioactive macrocyclic plant polypeptides in the Violaceae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Cyclic peptides from Oldenlandia affinis DC. Molecular and biological properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Dissecting the oxidative folding of circular cystine knot miniproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

New circulin macrocyclic polypeptides from Chassalia parvifolia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Cycloviolins A-D, anti-HIV macrocyclic peptides from Leonia cymosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Solution structure of the squash trypsin inhibitor MCoTI-II. A new family for cyclic knottins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Crystal Structure at 1.1 Å Resolution of α-Conotoxin PnIB: Comparison with α-Conotoxins PnIA and GI

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

The biological activity of the prototypic cyclotide kalata b1 is modulated by the formation of multimeric pores

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Cyclotides as natural anti-HIV agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

alpha-Conotoxins as selective probes for nicotinic acetylcholine receptor subclasses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Biosynthesis and insecticidal properties of plant cyclotides: the cyclic knotted proteins from Oldenlandia affinis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

MOLMOL: a program for display and analysis of macromolecular structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Solution structures by 1H NMR of the novel cyclic trypsin inhibitor SFTI-1 from sunflower seeds and an acyclic permutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Ultra-stable peptide scaffolds for protein engineering-synthesis and folding of the circular cystine knotted cyclotide cycloviolacin O2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Conus peptides: novel probes for nicotinic acetylcholine receptor structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Ziconotide: neuronal calcium channel blocker for treating severe chronic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Structure-activity relationships of alpha-conotoxins targeting neuronal nicotinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Backbone cyclised peptides from plants show molluscicidal activity against the rice pest Pomacea canaliculata (golden apple snail).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

The cyclotide cycloviolacin O2 from Viola odorata has potent bactericidal activity against Gram-negative bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Backbone dynamics of cyclotide MCoTI-I free and complexed with trypsin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Twists, knots, and rings in proteins. Structural definition of the cyclotide framework

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

A novel alpha-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Conformation and mode of membrane interaction in cyclotides. Spatial structure of kalata B1 bound to a dodecylphosphocholine micelle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Divalent cation coordination and mode of membrane interaction in cyclotides: NMR spatial structure of ternary complex Kalata B7/Mn2 /DPC micelle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Discovering high-affinity ligands for proteins: SAR by NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

A continent of plant defense peptide diversity: cyclotides in Australian Hybanthus (Violaceae)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Alanine scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Cytotoxic cyclotides from Viola tricolor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Thia Zip Reaction for Synthesis of Large Cyclic Peptides: Mechanisms and Applications†

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Conus venoms: a rich source of novel ion channel-targeted peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Circular proteins--no end in sight

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Synthetic therapeutic peptides: science and market

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Despite a Conserved Cystine Knot Motif, Different Cyclotides Have Different Membrane Binding Modes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Cyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Distribution and evolution of circular miniproteins in flowering plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00249-011-0672-9

Squash trypsin inhibitors from Momordica cochinchinensis exhibit an atypical macrocyclic structure

21 January 2018

1 reference

12 December 2020

Studies on the membrane interactions of the cyclotides kalata B1 and kalata B6 on model membrane systems by surface plasmon resonance

1 reference

12 December 2020

The role of the cyclic peptide backbone in the anti-HIV activity of the cyclotide kalata B1

1 reference

12 December 2020

Cyclotides: a novel type of cytotoxic agents

1 reference

12 December 2020

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

1 reference

12 December 2020

The cyclotides and related macrocyclic peptides as scaffolds in drug design

1 reference

12 December 2020

On the Effect of a Polypeptide Isolated from “Kalata-Kalata” (Oldenlandia affinis DC) on the Oestrogen Dominated Uterus

1 reference

12 December 2020

Automated structure determination from NMR spectra

1 reference

12 December 2020

Oxytocic principles of Oldenlandia affinis

1 reference

12 December 2020

10.1007/S00249-011-0672-9

Identifiers

DOI

1 reference

21 June 2017

1 reference