Dose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimer's disease cybrid cells. (Q30371544)

11 August 2017

Dose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimer's disease cybrid cells. (English)

1 reference

11 August 2017

1 reference

1 reference

1

1 reference

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15 June 2020

Jun Young Chang

3

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15 June 2020

Paul A. Lapchak

7

1 reference

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15 June 2020

Moon-Ku Han

8

1 reference

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15 June 2020

4

Manho Kim

1 reference

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15 June 2020

author name string

Kyu Sun Yum

2

1 reference

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15 June 2020

Jin-young Ahn

5

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15 June 2020

SangYun Kim

6

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15 June 2020

publication date

31 July 2015

1 reference

11 August 2017

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15 June 2020

volume

15

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15 June 2020

page(s)

127

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Creative Commons Attribution 4.0 International

15 June 2020

copyright license

start time

31 July 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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3 June 2018

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Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation

3 June 2018

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Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein

3 June 2018

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Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

3 June 2018

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Statins inhibit the dimerization of beta-secretase via both isoprenoid- and cholesterol-mediated mechanisms

3 June 2018

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3 June 2018

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Altered intracellular signaling and reduced viability of Alzheimer's disease neuronal cybrids is reproduced by beta-amyloid peptide acting through receptor for advanced glycation end products (RAGE).

3 June 2018

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Interactions between Alzheimer's disease and cerebral ischemia--focus on inflammation

3 June 2018

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Endogenous oxidative stress in sporadic Alzheimer's disease neuronal cybrids reduces viability by increasing apoptosis through pro-death signaling pathways and is mimicked by oxidant exposure of control cybrids

3 June 2018

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Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism.

3 June 2018

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3 June 2018

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HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells

3 June 2018

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Alzheimer disease as a vascular disorder: nosological evidence

3 June 2018

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Statins and the risk of dementia

3 June 2018

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The role of cholesterol in the biosynthesis of beta-amyloid

3 June 2018

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Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

3 June 2018

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3 June 2018

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The regulation of beta-secretase by cholesterol and statins in Alzheimer's disease

3 June 2018

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HMG-CoA reductase inhibitors reduce MMP-9 secretion by macrophages

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PubMed

https://pubmed.ncbi.nlm.nih.gov/26228060

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/S12883-015-0390-5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26228060 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

15 June 2020

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/s12883-015-0390-5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26228060 AND SRC:MED&resulttype=core&format=json

15 June 2020

PubMed publication ID

26228060

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26228060 AND SRC:MED&resulttype=core&format=json