Exploring the structure of the voltage-gated Na channel by an engineered drug access pathway to the receptor site for local anesthetics. (Q30363787)

16 October 2017

Exploring the structure of the voltage-gated Na channel by an engineered drug access pathway to the receptor site for local anesthetics. (English)

1 reference

16 October 2017

0 references

Vaibhavkumar S Gawali

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24947510 AND SRC:MED&resulttype=core&format=json

9 June 2020

Xaver Koenig

5

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9 June 2020

Karlheinz Hilber

8

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9 June 2020

author name string

Peter Lukacs

1

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9 June 2020

Rene Cervenka

3

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9 June 2020

Song Ke

4

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9 June 2020

Lena Rubi

6

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9 June 2020

Touran Zarrabi

7

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9 June 2020

Anna Stary-Weinzinger

9

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9 June 2020

Hannes Todt

10

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9 June 2020

language of work or name

English

0 references

publication date

19 June 2014

1 reference

16 October 2017

12

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

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9 June 2020

volume

289

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9 June 2020

issue

31

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9 June 2020

page(s)

21770-21781

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24947510 AND SRC:MED&resulttype=core&format=json

Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing

9 June 2020

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3 June 2018

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Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

3 June 2018

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In silico analysis of conformational changes induced by mutation of aromatic binding residues: consequences for drug binding in the hERG K channel

3 June 2018

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3 June 2018

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The crystal structure of a voltage-gated sodium channel

3 June 2018

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3 June 2018

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A Molecular Switch between the Outer and the Inner Vestibules of the Voltage-gated Na Channel

3 June 2018

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Structural basis for the coupling between activation and inactivation gates in K( ) channels

3 June 2018

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The tetrodotoxin binding site is within the outer vestibule of the sodium channel

3 June 2018

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The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na( ) channel

3 June 2018

1 reference

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Access and binding of local anesthetics in the closed sodium channel

3 June 2018

1 reference

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Comparison of multiple Amber force fields and development of improved protein backbone parameters

3 June 2018

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International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels

3 June 2018

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Novel Brugada syndrome-causing mutation in ion-conducting pore of cardiac Na channel does not affect ion selectivity properties

3 June 2018

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Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands

3 June 2018

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Tryptophan scanning of D1S6 and D4S6 C-termini in voltage-gated sodium channels

3 June 2018

1 reference

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Involvement of local anesthetic binding sites on IVS6 of sodium channels in fast and slow inactivation

3 June 2018

1 reference

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Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics.

3 June 2018

1 reference

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Cytoplasmic polyamines as permeant blockers and modulators of the voltage-gated sodium channel

3 June 2018

1 reference

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A structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence

3 June 2018

1 reference

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A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel

3 June 2018

1 reference

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A point mutation in domain 4-segment 6 of the skeletal muscle sodium channel produces an atypical inactivation state

3 June 2018

1 reference

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Ultra-slow inactivation in mu1 Na channels is produced by a structural rearrangement of the outer vestibule

3 June 2018

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Sodium channel selectivity filter regulates antiarrhythmic drug binding

3 June 2018

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On the structural basis for size-selective permeation of organic cations through the voltage-gated sodium channel. Effect of alanine mutations at the DEKA locus on selectivity, inhibition by Ca2 and H , and molecular sieving

3 June 2018

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Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperature

3 June 2018

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Altered ionic selectivity of the sodium channel revealed by cysteine mutations within the pore

3 June 2018

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Pore properties of rat brain II sodium channels mutated in the selectivity filter domain

3 June 2018

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Local anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deficient rat skeletal muscle Na channels

3 June 2018

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On the structural basis for ionic selectivity among Na , K , and Ca2 in the voltage-gated sodium channel

3 June 2018

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3 June 2018

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A mu-conotoxin-insensitive Na channel mutant: possible localization of a binding site at the outer vestibule

3 June 2018

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Molecular determinants of drug access to the receptor site for antiarrhythmic drugs in the cardiac Na channel

3 June 2018

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Molecular determinants of state-dependent block of Na channels by local anesthetics

3 June 2018

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A mutation in segment IVS6 disrupts fast inactivation of sodium channels

3 June 2018

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The pore dimensions of gramicidin A.

3 June 2018

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Lidocaine block of cardiac sodium channels

3 June 2018

1 reference

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The site of action and active form of local anesthetics. II. Experiments with quaternary compounds

3 June 2018

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The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of Lidocaine

3 June 2018

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Is there a second external lidocaine binding site on mammalian cardiac cells?

3 June 2018

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Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II.

3 June 2018

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Calcium channel characteristics conferred on the sodium channel by single mutations

3 June 2018

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Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction

3 June 2018

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Cardiac-specific external paths for lidocaine, defined by isoform-specific residues, accelerate recovery from use-dependent block

3 June 2018

1 reference

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Unexpected mexiletine responses of a mutant cardiac Na channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access

21 January 2018

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Architecture and pore block of eukaryotic voltage-gated sodium channels in view of NavAb bacterial sodium channel structure

21 January 2018

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Comparison of simple potential functions for simulating liquid water

21 January 2018

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Distinct interactions of Na and Ca2 ions with the selectivity filter of the bacterial sodium channel Na(V)Ab

21 January 2018

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Compound-specific Na channel pore conformational changes induced by local anaesthetics

21 January 2018

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Membrane Protein Simulations Using AMBER Force Field and Berger Lipid Parameters

21 January 2018

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Permeation of water through the KcsA K channel

21 January 2018

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A multifunctional aromatic residue in the external pore vestibule of Na channels contributes to the local anesthetic receptor

21 January 2018

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ATP stimulates sympathetic transmitter release via presynaptic P2X purinoceptors

26 November 2018

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A critical role for transmembrane segment IVS6 of the sodium channel alpha subunit in fast inactivation

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24947510

12 December 2020

inferred from PubMed ID database lookup

KcsA crystal structure as framework for a molecular model of the Na( ) channel pore

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24947510

12 December 2020

inferred from PubMed ID database lookup

Depth asymmetries of the pore-lining segments of the Na channel revealed by cysteine mutagenesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24947510

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M113.541763

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24947510 AND SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24947510 AND SRC:MED&resulttype=core&format=json

9 June 2020

PubMed publication ID

24947510

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24947510 AND SRC:MED&resulttype=core&format=json