The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells. (Q30354602)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28504928 AND SRC:MED&resulttype=core&format=json

20 March 2020

title

The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells (English)

1 reference

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20 March 2020

0 references

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Transmembrane O-methyltransferase

1 reference

Transmembrane inner ear

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Protocadherin 15

1 reference

Lipoma HMGIC fusion partner-like 5

1 reference

Transmembrane channel-like gene family 2

1 reference

Transmembrane channel-like gene family 1

1 reference

author

Christopher L Cunningham

1

1 reference

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20 March 2020

Bo Zhao

4

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20 March 2020

Amanda Lauer

7

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20 March 2020

Ulrich Müller

8

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20 March 2020

6

Sarah Harkins-Perry

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20 March 2020

author name string

Zizhen Wu

2

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20 March 2020

Aria Jafari

3

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20 March 2020

Kat Schrode

5

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20 March 2020

language of work or name

English

0 references

publication date

15 May 2017

1 reference

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20 March 2020

1 reference

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20 March 2020

volume

6

1 reference

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Mechanosensory hair cells express two molecularly distinct mechanotransduction channels

20 March 2020

cites work

1 reference

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Neuroplastin Isoform Np55 Is Expressed in the Stereocilia of Outer Hair Cells and Required for Normal Outer Hair Cell Function.

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Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function.

3 June 2018

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Development and localization of reverse-polarity mechanotransducer channels in cochlear hair cells

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3 June 2018

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TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia

3 June 2018

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3 June 2018

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TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells.

3 June 2018

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The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells

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Transduction without tip links in cochlear hair cells is mediated by ion channels with permeation properties distinct from those of the mechano-electrical transducer channel.

3 June 2018

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3 June 2018

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TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear

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Sexually dimorphic effects of catechol-O-methyltransferase (COMT) inhibition on dopamine metabolism in multiple brain regions

3 June 2018

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TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells

3 June 2018

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Kinocilia mediate mechanosensitivity in developing zebrafish hair cells

3 June 2018

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Sensing sound: molecules that orchestrate mechanotransduction by hair cells

3 June 2018

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Mechanotransduction in mouse inner ear hair cells requires transmembrane channel–like genes

3 June 2018

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Enzymatic methyl transfer: role of an active site residue in generating active site compaction that correlates with catalytic efficiency.

3 June 2018

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Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity

3 June 2018

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Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction

3 June 2018

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Mutations in Protocadherin 15 and Cadherin 23 Affect Tip Links and Mechanotransduction in Mammalian Sensory Hair Cells

3 June 2018

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Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain

3 June 2018

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The catechol-O-methyltransferase gene: its regulation and polymorphisms

3 June 2018

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How the genetics of deafness illuminates auditory physiology

3 June 2018

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Hearing impairment: a panoply of genes and functions

3 June 2018

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Topology of Transmembrane Channel-like Gene 1 Protein

3 June 2018

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Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids

3 June 2018

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3 June 2018

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Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models

3 June 2018

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Calcium balance and mechanotransduction in rat cochlear hair cells

3 June 2018

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Harmonin mutations cause mechanotransduction defects in cochlear hair cells.

3 June 2018

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Fast adaptation and Ca2 sensitivity of the mechanotransducer require myosin-XVa in inner but not outer cochlear hair cells

3 June 2018

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Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans

3 June 2018

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A catechol-O-methyltransferase that is essential for auditory function in mice and humans

3 June 2018

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Stepwise morphological and functional maturation of mechanotransduction in rat outer hair cells.

3 June 2018

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Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells

3 June 2018

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A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function

3 June 2018

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Dopaminergic innervation of the mouse inner ear: evidence for a separate cytochemical group of cochlear efferent fibers

3 June 2018

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Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells

3 June 2018

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Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cells

3 June 2018

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Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia

3 June 2018

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Cadherin 23 is a component of the tip link in hair-cell stereocilia

3 June 2018

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Small molecule regulators of protein arginine methyltransferases

3 June 2018

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Sources and mechanisms of DPOAE generation: implications for the prediction of auditory sensitivity.

3 June 2018

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Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle

3 June 2018

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The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions

3 June 2018

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3 June 2018

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Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

3 June 2018

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Chemical synaptic transmission in the cochlea

3 June 2018

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Crystal structure of catechol O-methyltransferase

3 June 2018

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Neurotransmitters and neuromodulators of the mammalian cochlea

3 June 2018

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Functional structure of the organ of Corti: a review

3 June 2018

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Tip-link integrity and mechanical transduction in vertebrate hair cells

3 June 2018

1 reference

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Stimulated acoustic emissions from within the human auditory system

3 June 2018

1 reference

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Sinefungin, a potent inhibitor of S-adenosylmethionine: Protein O-methyltransferase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462538

Medicinal chemistry of catechol O-methyltransferase (COMT) inhibitors and their therapeutic utility

3 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.7554/ELIFE.24318

The development of links between stereocilia in hair cells of the chick basilar papilla

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.7554/ELIFE.24318

Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.7554/ELIFE.24318

ATP-Induced Ca(2 ) release in cochlear outer hair cells: localization of an inositol triphosphate-gated Ca(2 ) store to the base of the sensory hair bundle.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462538

The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28504928

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Plasma Membrane Ca2 -ATPase Extrudes Ca2 from Hair Cell Stereocilia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28504928

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.7554/ELIFE.24318

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28504928 AND SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28504928 AND SRC:MED&resulttype=core&format=json

20 March 2020

PubMed publication ID

28504928

1 reference