Kinetic analysis of the Ku-DNA binding activity reveals a redox-dependent alteration in protein structure that stimulates dissociation of the Ku-DNA complex (Q30353381)

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English	Kinetic analysis of the Ku-DNA binding activity reveals a redox-dependent alteration in protein structure that stimulates dissociation of the Ku-DNA complex	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Kinetic analysis of the Ku-DNA binding activity reveals a redox-dependent alteration in protein structure that stimulates dissociation of the Ku-DNA complex (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

author name string

Brooke J Andrews

1

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Europe PubMed Central

PMC publication ID

15 August 2017

Jason A Lehman

2

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Europe PubMed Central

PMC publication ID

15 August 2017

John J Turchi

3

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Europe PubMed Central

PMC publication ID

15 August 2017

language of work or name

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publication date

13 March 2006

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Europe PubMed Central

PMC publication ID

15 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

15 August 2017

281

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Europe PubMed Central

PMC publication ID

15 August 2017

19

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

13596-13603

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2432111/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Modulation of DNA-dependent protein kinase activity in chlorambucil-treated cells.

1 reference

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3 June 2018

Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.

1 reference

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Differential activation of DNA-PK based on DNA strand orientation and sequence bias

1 reference

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Phosphorylation of Artemis following irradiation-induced DNA damage

1 reference

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Fluorescence anisotropy studies on the Ku-DNA interaction: anion and cation effects

1 reference

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Mechanisms of DNA double strand break repair and chromosome aberration formation

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Development of a high-throughput screen for inhibitors of replication protein A and its role in nucleotide excision repair.

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Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress.

1 reference

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Requirement of the MRN complex for ATM activation by DNA damage

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Stopped-flow studies of the kinetics of single-stranded DNA binding and wrapping around the Escherichia coli SSB tetramer

1 reference

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Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

1 reference

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Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells

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Stopped-flow kinetic analysis of replication protein A-binding DNA: damage recognition and affinity for single-stranded DNA reveal differential contributions of k(on) and k(off) rate constants

1 reference

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3 June 2018

Cisplatin-DNA adducts inhibit translocation of the Ku subunits of DNA-PK.

1 reference

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Signal transduction and cellular radiation responses

1 reference

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Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein

1 reference

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3 June 2018

Mapping of protein-protein interactions within the DNA-dependent protein kinase complex

1 reference

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3 June 2018

Ku binds telomeric DNA in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432111

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The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit

1 reference

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Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432111

3 June 2018

Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks

1 reference

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Reduced sulphydryl groups are required for DNA binding of Ku protein

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Ionisation of cysteine residues at the termini of model alpha-helical peptides. Relevance to unusual thiol pKa values in proteins of the thioredoxin family.

1 reference

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Studies on the mode of Ku interaction with DNA.

1 reference

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21 January 2018

Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends.

1 reference

https://api.crossref.org/works/10.1074/JBC.M512787200

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Mutation in the glucose-6-phosphate dehydrogenase gene leads to inactivation of Ku DNA end binding during oxidative stress

1 reference

https://api.crossref.org/works/10.1074/JBC.M512787200

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Inhibition of cell survival and invasive potential of colorectal carcinoma cells by the tyrosine kinase inhibitor STI571.

1 reference

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Radiation induced oxidative stress: II studies in liver as a distant organ of tumor bearing mice

1 reference

https://api.crossref.org/works/10.1074/JBC.M512787200

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Radiation induced oxidative stress: I. Studies in Ehrlich solid tumor in mice

1 reference

https://api.crossref.org/works/10.1074/JBC.M512787200

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Oxidative stress induces nuclear loss of DNA repair proteins Ku70 and Ku80 and apoptosis in pancreatic acinar AR42J cells

1 reference

https://api.crossref.org/works/10.1074/JBC.M512787200

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Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks

1 reference

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Oxidation of cellular thiols by hydroxyethyldisulphide inhibits DNA double-strand-break rejoining in G6PD deficient mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16537541

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Mechanism of interaction between Ku protein and DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/16537541

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HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/16537541

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Reactivity and ionization of the active site cysteine residues of DsbA, a protein required for disulfide bond formation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16537541

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Human Ku autoantigen binds cisplatin-damaged DNA but fails to stimulate human DNA-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16537541

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Photocross-linking of an oriented DNA repair complex. Ku bound at a single DNA end

1 reference

https://pubmed.ncbi.nlm.nih.gov/16537541

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Identifiers

10.1074/JBC.M512787200

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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