High-throughput crystallography for lead discovery in drug design. (Q30331190)

18 June 2017

1 reference

title

High-throughput crystallography for lead discovery in drug design. (English)

1 reference

18 June 2017

1 reference

1

Tom L Blundell

1 reference

18 June 2017

Harren Jhoti

2

1 reference

18 June 2017

Chris Abell

series ordinal

3

1 reference

18 June 2017

publication date

1 January 2002

1 reference

Nature Reviews Drug Discovery

18 June 2017

published in

1 reference

18 June 2017

volume

1

1 reference

18 June 2017

issue

1

1 reference

18 June 2017

page(s)

45-54

1 reference

Structural genomics: an overview

18 June 2017

cites work

1 reference

Protein structure--based drug design

31 March 2020

1 reference

Inflammation. Signalling the fat controller

31 March 2020

1 reference

Application of the three-dimensional structures of protein target molecules in structure-based drug design

31 March 2020

1 reference

Retroviral protease-like sequence in the yeast transposon Ty 1

31 March 2020

1 reference

18th Sir Hans Krebs lecture. Knowledge-based protein modelling and design

31 March 2020

1 reference

A structural model for the retroviral proteases.

31 March 2020

1 reference

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

31 March 2020

1 reference

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

31 March 2020

1 reference

The in silico world of virtual libraries

31 March 2020

1 reference

MS/NMR: a structure-based approach for discovering protein ligands and for drug design by coupling size exclusion chromatography, mass spectrometry, and nuclear magnetic resonance spectroscopy

31 March 2020

1 reference

Implementing surface plasmon resonance biosensors in drug discovery

31 March 2020

1 reference

Privileged molecules for protein binding identified from NMR-based screening

31 March 2020

1 reference

The SHAPES strategy: an NMR-based approach for lead generation in drug discovery.

31 March 2020

1 reference

Fluorescence correlations, single molecule detection and large number screening. Applications in biotechnology

31 March 2020

1 reference

Discovering novel ligands for macromolecules using X-ray crystallographic screening

31 March 2020

1 reference

31 March 2020

The Protein Data Bank

1 reference

High-throughput three-dimensional protein structure determination.

31 March 2020

1 reference

Protein crystallization by rational mutagenesis of surface residues: Lys to Ala mutations promote crystallization of RhoGDI

31 March 2020

2 references

31 March 2020

inferred from DOI database lookup

7 January 2021

based on heuristic

High-throughput proteomics: protein expression and purification in the postgenomic world.

1 reference

Rapid protein-folding assay using green fluorescent protein

31 March 2020

1 reference

Cell-free production and stable-isotope labeling of milligram quantities of proteins

31 March 2020

1 reference

High-throughput protein crystallization

31 March 2020

1 reference

Development of a technology for automation and miniaturization of protein crystallization.

31 March 2020

1 reference

Automation of X-ray crystallography

31 March 2020

1 reference

Automated crystal mounting and data collection for protein crystallography

31 March 2020

1 reference

Current state of automated crystallographic data analysis.

31 March 2020

1 reference

[28] Phase determination from multiwavelength anomalous diffraction measurements

31 March 2020

1 reference

[37] Patterson superposition and ab initio phasing

31 March 2020

1 reference

Optimizing Shake-and-Bake for proteins.

31 March 2020

1 reference

Automated MAD and MIR structure solution

31 March 2020

1 reference

Crystal structure, compressibility and possible phase transitions in \boldvarepsilon-FeSi studied by first-principles pseudopotential calculations.

31 March 2020

1 reference

Automated protein model building combined with iterative structure refinement

31 March 2020

1 reference

Knowledge-Based Protein Modeling

31 March 2020

1 reference

GenTHREADER: an efficient and reliable protein fold recognition method for genomic sequences

31 March 2020

1 reference

FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties

31 March 2020

1 reference

Comparative protein modelling by satisfaction of spatial restraints

31 March 2020

1 reference

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

31 March 2020

1 reference

High-throughput docking for lead generation

31 March 2020

1 reference

A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

31 March 2020

1 reference

ICM?A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation

31 March 2020

1 reference

Reaching the global minimum in docking simulations: a Monte Carlo energy minimization approach using Bezier splines

31 March 2020

1 reference

Rational discovery of novel nuclear hormone receptor antagonists

31 March 2020

1 reference

Molecular recognition using a binary genetic search algorithm.

31 March 2020

1 reference

Automated site-directed drug design: a method for the generation of general three-dimensional molecular graphs

31 March 2020

1 reference

GenStar: a method for de novo drug design.

31 March 2020

1 reference

Functionality maps of binding sites: a multiple copy simultaneous search method

31 March 2020

1 reference

LUDI: rule-based automatic design of new substituents for enzyme inhibitor leads

31 March 2020

1 reference

Evaluation of PMF scoring in docking weak ligands to the FK506 binding protein

31 March 2020

1 reference

Knowledge-based scoring function to predict protein-ligand interactions.

31 March 2020

1 reference

Protein-based virtual screening of chemical databases. 1. Evaluation of different docking/scoring combinations.

31 March 2020

1 reference

Discovering high-affinity ligands for proteins: SAR by NMR

31 March 2020

1 reference

The additivity of substrate fragments in enzyme-ligand binding

31 March 2020

1 reference

Virtual screening—an overview

31 March 2020

1 reference

Drug discovery: a historical perspective

31 March 2020

1 reference

Initial sequencing and analysis of the human genome

31 March 2020

1 reference

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD706

1 reference

18 June 2017

1 reference