Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance (Q30274556)

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English	Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance	scientific article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20005821 AND SRC:MED&resulttype=core&format=json

15 January 2020

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance (English)

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20005821 AND SRC:MED&resulttype=core&format=json

15 January 2020

negative regulation of astrocyte activation

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

regulation of astrocyte activation

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

positive regulation of astrocyte activation

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

1 reference

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

LDL receptor related protein 1

1 reference

GOA release 2020-03-11

Very low density lipoprotein receptor

1 reference

GOA release 2020-03-11

apolipoproteins E

1 reference

GOA release 2020-03-11

LDL receptor related protein 8

1 reference

GOA release 2020-03-11

Low density lipoprotein receptor

1 reference

GOA release 2020-03-11

Sortilin related receptor 1

1 reference

GOA release 2020-03-11

Amyloid beta precursor protein

1 reference

GOA release 2020-03-11

low-density lipoprotein particle receptor activity

1 reference

GOA release 2020-03-11

Apolipoprotein E

1 reference

GOA release 2020-03-11

Low density lipoprotein receptor

1 reference

GOA release 2020-03-11

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1

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15 January 2020

Joseph M Castellano

2

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15 January 2020

David M. Holtzman

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David M Holtzman

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15 January 2020

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Hong Jiang

3

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15 January 2020

Jacob M Basak

4

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15 January 2020

Maia Parsadanian

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15 January 2020

Vi Pham

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15 January 2020

Stephanie M Mason

7

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15 January 2020

Steven M Paul

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15 January 2020

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1 December 2009

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15 January 2020

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15 January 2020

64

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15 January 2020

5

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15 January 2020

632-644

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15 January 2020

describes a project that uses

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Europe PubMed Central

11 June 2022

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based on heuristic

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The role of apolipoprotein E in Alzheimer's disease

1 reference

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3 June 2018

Apolipoprotein E receptors in the nervous system

1 reference

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3 June 2018

Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan

1 reference

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3 June 2018

ApoE promotes the proteolytic degradation of Abeta

1 reference

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Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

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Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.

1 reference

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Sex-dependent association of a common low-density lipoprotein receptor polymorphism with RNA splicing efficiency in the brain and Alzheimer's disease

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3 June 2018

The Alzheimer's disease beta-secretase enzyme, BACE1.

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3 June 2018

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

1 reference

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Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

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3 June 2018

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

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3 June 2018

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3 June 2018

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Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein

1 reference

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Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

1 reference

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Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

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Lipoprotein receptors in the nervous system

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gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

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3 June 2018

Intramembrane proteolysis by presenilins

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Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice

1 reference

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Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

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Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

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Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition

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1 reference

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1 reference

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12 December 2020

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10.1016/J.NEURON.2009.11.013

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Europe PubMed Central

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15 January 2020

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Europe PubMed Central

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15 January 2020

PubMed publication ID

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Europe PubMed Central

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15 January 2020

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