Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin (Q30273805)

13 October 2017

Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin (English)

1 reference

13 October 2017

1 reference

Ghazaleh Ashrafi

1

1 reference

13 October 2017

Julia S Schlehe

series ordinal

2

1 reference

13 October 2017

Matthew J LaVoie

series ordinal

3

1 reference

13 October 2017

Thomas L Schwarz

series ordinal

4

1 reference

13 October 2017

language of work or name

English

0 references

publication date

25 August 2014

1 reference

13 October 2017

Journal of Cell Biology

1 reference

13 October 2017

206

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13 October 2017

5

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13 October 2017

655-670

1 reference

describes a project that uses

13 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4151150/fullTextXML

inferred from PubMed Central ID database lookup

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Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control

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A further update on the role of excitotoxicity in the pathogenesis of Parkinson's disease

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MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age

3 June 2018

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Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up?

3 June 2018

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The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

3 June 2018

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Reconstitution of mitochondria derived vesicle formation demonstrates selective enrichment of oxidized cargo

3 June 2018

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Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons

3 June 2018

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3 June 2018

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The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax

3 June 2018

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Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

3 June 2018

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Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons

3 June 2018

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Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

3 June 2018

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Axon degeneration in Parkinson's disease

3 June 2018

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PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

3 June 2018

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Autophagy: renovation of cells and tissues

3 June 2018

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Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy

3 June 2018

1 reference

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Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells

3 June 2018

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3 June 2018

Mechanisms of mitophagy

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Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization.

3 June 2018

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Mitophagy Selectively Degrades Individual Damaged Mitochondria After Photoirradiation

3 June 2018

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Microfluidic local perfusion chambers for the visualization and manipulation of synapses

3 June 2018

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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

3 June 2018

1 reference

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

3 June 2018

1 reference

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Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases

3 June 2018

1 reference

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Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release

3 June 2018

1 reference

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Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission

3 June 2018

1 reference

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Live-cell imaging of autophagy induction and autophagosome-lysosome fusion in primary cultured neurons

3 June 2018

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Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking

3 June 2018

1 reference

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

3 June 2018

1 reference

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Mitochondrial membrane potential in axons increases with local nerve growth factor or semaphorin signaling

3 June 2018

1 reference

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Autophagosome formation: core machinery and adaptations

3 June 2018

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Regulation of mitochondrial matrix volume

3 June 2018

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Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent

3 June 2018

1 reference

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Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled.

3 June 2018

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

3 June 2018

1 reference

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

3 June 2018

1 reference

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A genetically encoded photosensitizer

3 June 2018

1 reference

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A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

3 June 2018

1 reference

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A microfluidic culture platform for CNS axonal injury, regeneration and transport

3 June 2018

1 reference

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MPTP as a mitochondrial neurotoxic model of Parkinson's disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151150

Visualization of retroviral replication in living cells reveals budding into multivesicular bodies.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151150

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151150

Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151150

Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151150

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

3 June 2018

1 reference

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The mechanism of action of the respiratory inhibitor, antimycin

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151150

Axonal and dendritic endocytic pathways in cultured neurons

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151150

Local pruning of dendrites and spines by caspase-3-dependent and proteasome-limited mechanisms.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151150

Recognizing the cooperative and independent mitochondrial functions of Parkin and PINK1.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151150

A vesicular transport pathway shuttles cargo from mitochondria to lysosomes.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151150

A genetic model to dissect the role of Tsc-mTORC1 in neuronal cultures

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151150

Spatiotemporally controlled initiation of Parkin-mediated mitophagy within single cells

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151150

What causes the death of dopaminergic neurons in Parkinson's disease?

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151150

Human brain cortex: mitochondrial oxidative damage and adaptive response in Parkinson disease and in dementia with Lewy bodies

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151150

Mitochondrial trafficking to synapses in cultured primary cortical neurons.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151150

Axonal mitochondrial transport and potential are correlated

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151150

Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151150

Axonal transport of mitochondria to synapses depends on milton, a novel Drosophila protein

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151150

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25154397

12 December 2020

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/25154397

12 December 2020

inferred from PubMed ID database lookup

In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25154397

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1083/JCB.201401070

1 reference

13 October 2017

1 reference

13 October 2017

PubMed publication ID

25154397

1 reference