T Cells Deficient in the Tyrosine Phosphatase SHP-1 Resist Suppression by Regulatory T Cells (Q30252330)

13 June 2017

title

T Cells Deficient in the Tyrosine Phosphatase SHP-1 Resist Suppression by Regulatory T Cells (English)

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13 June 2017

Ulrike M Lorenz

2

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author name string

Emily R Mercadante

series ordinal

1

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13 June 2017

language of work or name

English

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publication date

26 May 2017

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13 June 2017

published in

Journal of Immunology

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Phenotypical and functional specialization of FOXP3 regulatory T cells

13 June 2017

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Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

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Shp1 regulates T cell homeostasis by limiting IL-4 signals

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Targeted loss of SHP1 in murine thymocytes dampens TCR signaling late in selection

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Selective expression of the Cre recombinase in late-stage thymocytes using the distal promoter of the Lck gene.

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B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity.

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Deficiency of the Src homology region 2 domain-containing phosphatase 1 (SHP-1) causes enrichment of CD4 CD25 regulatory T cells

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Allograft rejection mediated by memory T cells is resistant to regulation

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Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells

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SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells

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IL-15 renders conventional lymphocytes resistant to suppressive functions of regulatory T cells through activation of the phosphatidylinositol 3-kinase pathway

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'Vive la Résistance!'--the PI3K-Akt pathway can determine target sensitivity to regulatory T cell suppression

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Anti-tumor necrosis factor α targets protein kinase B/c-Akt-induced resistance of effector cells to suppression in juvenile idiopathic arthritis

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Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase

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In vivo Treg suppression assays

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Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation

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4-1BB-dependent inhibition of immunosuppression by activated CD4 CD25 T cells

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CD137 costimulation of CD8 T cells confers resistance to suppression by virus-induced regulatory T cells

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OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

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Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function.

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Involvement of the SHP-1 tyrosine phosphatase in regulation of T cell selection

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SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity

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12 December 2020

Ex vivo expansion of CD4 CD25 FoxP3 T regulatory cells based on synergy between IL-2 and 4-1BB signaling

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12 December 2020

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12 December 2020

TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis

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Self-Sustained Resistance to Suppression of CD8 Teff Cells at the Site of Autoimmune Inflammation Can Be Reversed by Tumor Necrosis Factor and Interferon-γ Blockade

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High antigen dose and activated dendritic cells enable Th cells to escape regulatory T cell-mediated suppression in vitro

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Identifiers

DOI

10.4049/JIMMUNOL.1602171

1 reference

13 June 2017

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