Natural mutations in a Staphylococcus aureus virulence regulator attenuate cytotoxicity but permit bacteremia and abscess formation (Q30017477)

21

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Claudia Lindemann

Claudia Lindemann

2

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Amy Flaxman

Amy Flaxman

12

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Sudip Das

Sudip Das

1

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Nicola Ternette

Nicola Ternette

6

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Ruth C. Massey

Ruth Massey

24

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Richard Reinhardt

Richard Reinhardt

9

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Derrick W Crook

23

Derrick W. Crook

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Elizabeth R. Allen

Elizabeth Allen

11

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Daniel Wilson

Daniel J. Wilson

25

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Julius Müller

4

Julius Muller

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Thomas Rudel

26

Thomas Rudel

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Martin Fraunholz

Martin J. Fraunholz

28

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author name string

Bernadette C. Young

3

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Babett Österreich

5

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Ann-Cathrin Winkler

7

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Kerstin Paprotka

8

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Yuko Yamaguchi

13

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Christine S. Rollier

14

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Pauline van Diemen

15

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Sebastian Blättner

16

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Christian W. Remmele

17

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Martina Selle

18

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Marcus Dittrich

19

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Tobias Müller

20

0 references

Knut Ohlsen

22

0 references

David H. Wyllie

Proceedings of the National Academy of Sciences of the United States of America

27

0 references

language of work or name

English

0 references

publication date

16 May 2016

0 references

published in

1 reference

Staphylococcal manipulation of host immune responses

PubMed

volume

113

0 references

issue

22

0 references

page(s)

E3101-E3110

0 references

cites work

1 reference

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Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tactic

23 May 2017

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Stampy: a statistical algorithm for sensitive and fast mapping of Illumina sequence reads

23 May 2017

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Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways

23 May 2017

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The primary transcriptome of the major human pathogen Helicobacter pylori

23 May 2017

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The Sequence Alignment/Map format and SAMtools

23 May 2017

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Velvet: algorithms for de novo short read assembly using de Bruijn graphs

23 May 2017

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Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia

23 May 2017

1 reference

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Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA

23 May 2017

1 reference

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Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance

23 May 2017

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Staphylococcus aureus infections

23 May 2017

1 reference

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PEAKS DB: De Novo Sequencing Assisted Database Search for Sensitive and Accurate Peptide Identification

23 May 2017

1 reference

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AraC-Type Regulator Rsp Adapts Staphylococcus aureus Gene Expression to Acute Infection.

23 May 2017

1 reference

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Evolutionary Trade-Offs Underlie the Multi-faceted Virulence of Staphylococcus aureus

3 June 2018

1 reference

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Proteomic Identification of saeRS-Dependent Targets Critical for Protective Humoral Immunity against Staphylococcus aureus Skin Infection

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Staphylococcus aureus dynamically adapts global regulators and virulence factor expression in the course from acute to chronic infection

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Methicillin-resistant Staphylococcus aureus adaptation to human keratinocytes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Cytotoxic Virulence Predicts Mortality in Nosocomial Pneumonia Due to Methicillin-Resistant Staphylococcus aureus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Transcriptional landscape and essential genes of Neisseria gonorrhoeae

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

The bicomponent pore-forming leucocidins of Staphylococcus aureus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Hyperexpression of α-hemolysin explains enhanced virulence of sequence type 93 community-associated methicillin-resistant Staphylococcus aureus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Staphylococcus aureus degrades neutrophil extracellular traps to promote immune cell death

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Complete Genome Sequence of Staphylococcus aureus 6850, a Highly Cytotoxic and Clinically Virulent Methicillin-Sensitive Strain with Distant Relatedness to Prototype Strains

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

National burden of invasive methicillin-resistant Staphylococcus aureus infections, United States, 2011.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Staphylococcal proteases aid in evasion of the human complement system

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Neutrophils versus Staphylococcus aureus: a biological tug of war.

3 June 2018

1 reference

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A genetic resource for rapid and comprehensive phenotype screening of nonessential Staphylococcus aureus genes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

The economic burden of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA).

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

A privileged intraphagocyte niche is responsible for disseminated infection of Staphylococcus aureus in a zebrafish model

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Characterization of SSR42, a novel virulence factor regulatory RNA that contributes to the pathogenesis of a Staphylococcus aureus USA300 representative.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Evolutionary dynamics of Staphylococcus aureus during progression from carriage to disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

De novo assembly and genotyping of variants using colored de Bruijn graphs

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Genome-wide antisense transcription drives mRNA processing in bacteria

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Molecular differentiation of historic phage-type 80/81 and contemporary epidemic Staphylococcus aureus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Rsp Inhibits Attachment and Biofilm Formation by Repressing fnbA in Staphylococcus aureus MW2

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

The Sbi protein is a multifunctional immune evasion factor of Staphylococcus aureus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Control of bacterial virulence by AraC-like regulators that respond to chemical signals

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Importance of the Global Regulators Agr and SaeRS in the Pathogenesis of CA-MRSA USA300 Infection

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Nuclease expression by Staphylococcus aureus facilitates escape from neutrophil extracellular traps

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

agr-Dependent Interactions of Staphylococcus aureus USA300 with Human Polymorphonuclear Neutrophils

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

The staphylococcus-specific gene rsr represses agr and virulence in Staphylococcus aureus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Identification of a novel Staphylococcus aureus two-component leukotoxin using cell surface proteomics

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Rbf promotes biofilm formation by Staphylococcus aureus via repression of icaR, a negative regulator of icaADBC.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Staphylococcus aureus mutant screen reveals interaction of the human antimicrobial peptide dermcidin with membrane phospholipids

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Phagocytosis of Staphylococcus aureus by macrophages exerts cytoprotective effects manifested by the upregulation of antiapoptotic factors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Surface proteins that promote adherence of Staphylococcus aureus to human desquamated nasal epithelial cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

agr function in clinical Staphylococcus aureus isolates.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Complement evasion by human pathogens

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

SAMMD: Staphylococcus aureus microarray meta-database

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Staphylococcus aureus capsular polysaccharides

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

The Staphylococcus aureus Map protein is an immunomodulator that interferes with T cell-mediated responses

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Alteration of the repressor activity of MarR, the negative regulator of the Escherichia coli marRAB locus, by multiple chemicals in vitro.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Internalization of Staphylococcus aureus by endothelial cells induces apoptosis.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Intracellular Staphylococcus aureus Escapes the Endosome and Induces Apoptosis in Epithelial Cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Ingestion of Staphylococcus aureus by bovine endothelial cells results in time- and inoculum-dependent damage to endothelial cell monolayers.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4896717

Molecular mechanisms of complement evasion: learning from staphylococci and meningococci

3 June 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1520255113

Preventing surgical-site infections in nasal carriers of Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1520255113

Staphylococcus aureus isolates from chronic osteomyelitis are characterized by high host cell invasion and intracellular adaptation, but still induce inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1520255113

Multiple virulence factors are required for Staphylococcus aureus-induced apoptosis in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1520255113

Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1520255113

Neutrophil microbicides induce a pathogen survival response in community-associated methicillin-resistant Staphylococcus aureus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1520255113

Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1520255113

xBASE2: a comprehensive resource for comparative bacterial genomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1520255113

Virulence factors of Staphylococcus aureus in the pathogenesis of endocarditis. A comparative study of clinical isolates.

21 January 2018

1 reference

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Are bloodstream leukocytes Trojan Horses for the metastasis of Staphylococcus aureus?

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27188639

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Prevalence of agr dysfunction among colonizing Staphylococcus aureus strains

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27188639