ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63 (Q30009543)

21 May 2017

title

ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63 (English)

1 reference

21 May 2017

16

Holger Moch

1 reference

21 May 2017

Luca Tordella

1

1 reference

21 May 2017

Sofia Koch

2

1 reference

21 May 2017

Victoria Salter

3

1 reference

21 May 2017

Anna Pagotto

4

1 reference

21 May 2017

Jessica B Doondeea

5

1 reference

21 May 2017

Stephan M Feller

6

1 reference

21 May 2017

Indrika Ratnayaka

7

1 reference

21 May 2017

Shan Zhong

8

1 reference

21 May 2017

Robert D Goldin

9

1 reference

21 May 2017

Guillermina Lozano

10

1 reference

21 May 2017

Frank D McKeon

11

1 reference

21 May 2017

Mahvash Tavassoli

12

1 reference

21 May 2017

Florian Fritzsche

13

1 reference

21 May 2017

Gerhard F Huber

14

1 reference

21 May 2017

Matthias Rössle

15

1 reference

21 May 2017

Xin Lu

17

1 reference

21 May 2017

language of work or name

English

0 references

publication date

14 October 2013

1 reference

Proceedings of the National Academy of Sciences of the United States of America

21 May 2017

published in

1 reference

21 May 2017

volume

110

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21 May 2017

issue

44

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21 May 2017

page(s)

17969-17974

1 reference

Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP

21 May 2017

cites work

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22 May 2017

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Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases

22 May 2017

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A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas

22 May 2017

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ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth

22 May 2017

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Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation

22 May 2017

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ASPP1 and ASPP2: common activators of p53 family members

22 May 2017

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ASPP proteins specifically stimulate the apoptotic function of p53

22 May 2017

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In vivo gene expression profile analysis of human breast cancer progression

22 May 2017

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NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2

22 May 2017

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p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

22 May 2017

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p63 is a p53 homologue required for limb and epidermal morphogenesis

22 May 2017

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ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells

22 May 2017

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Autophagic activity dictates the cellular response to oncogenic RAS.

3 June 2018

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Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification

3 June 2018

1 reference

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iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia.

3 June 2018

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TP63 P2 promoter functional analysis identifies β-catenin as a key regulator of ΔNp63 expression

3 June 2018

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ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis

3 June 2018

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Regulation of ΔNp63α by NFκΒ

3 June 2018

1 reference

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SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence

3 June 2018

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ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development

3 June 2018

1 reference

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Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds

3 June 2018

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BALB/c and C57BL6 mouse strains vary in their ability to heal corneal epithelial debridement wounds

3 June 2018

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Mechanisms regulating epithelial stratification

3 June 2018

1 reference

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TAp63 and DeltaNp63 in cancer and epidermal development

3 June 2018

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Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816480

Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816480

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

3 June 2018

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p63 expression profiles in human normal and tumor tissues

3 June 2018

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Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome

3 June 2018

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Alterations in NF-κB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-κB

3 June 2018

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Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

3 June 2018

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3 June 2018

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Dominant negative p63 isoform expression in head and neck squamous cell carcinoma

26 November 2018

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NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

26 November 2018

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Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-kappaB signaling

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816480

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816480

Sunburn and p53 in the onset of skin cancer

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24127607

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of Retinoblastoma and Trp53 Tumor Suppressors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24127607

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1309362110

1 reference

ADS bibcode

2013PNAS..11017969T

0 references

1 reference

1 reference

1 reference