Discs overgrown Dmel_CG2048 (Q29819605)

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

1 reference

8 April 2019

protein binding

3 references

8 April 2019

Noncanonical FK506-binding protein BDBT binds DBT to enhance its circadian function and forms foci at night.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

Drosophila DBT lacking protein kinase activity produces long-period and arrhythmic circadian behavioral and molecular rhythms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

A DOUBLETIME kinase binding domain on the Drosophila PERIOD protein is essential for its hyperphosphorylation, transcriptional repression, and circadian clock function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

1 reference

8 April 2019

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

9 references

8 April 2019

8 April 2019

Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

8 April 2019

Regulation of wingless signaling by the CKI family in Drosophila limb development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

Drosophila DBT lacking protein kinase activity produces long-period and arrhythmic circadian behavioral and molecular rhythms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

Drosophila and vertebrate casein kinase Idelta exhibits evolutionary conservation of circadian function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

1 reference

8 April 2019

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

8 references

7 November 2018

7 November 2018

CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

7 November 2018

Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

7 November 2018

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

7 November 2018

Drosophila and vertebrate casein kinase Idelta exhibits evolutionary conservation of circadian function

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

7 November 2018

Regulation of wingless signaling by the CKI family in Drosophila limb development.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

7 November 2018

Drosophila DBT lacking protein kinase activity produces long-period and arrhythmic circadian behavioral and molecular rhythms

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

cell component

nucleus

Genetic analysis of the circadian system in Drosophila melanogaster and mammals

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

27 March 2018

Regulation of wingless signaling by the CKI family in Drosophila limb development.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

27 March 2018

Developmental profiles of PERIOD and DOUBLETIME in Drosophila melanogaster ovary.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

1 reference

8 April 2019

cytoplasm

Genetic analysis of the circadian system in Drosophila melanogaster and mammals

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

27 March 2018

Regulation of wingless signaling by the CKI family in Drosophila limb development.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

27 March 2018

Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

27 March 2018

Developmental profiles of PERIOD and DOUBLETIME in Drosophila melanogaster ovary.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

1 reference

8 April 2019

plasma membrane

1 reference

8 April 2019

Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

nucleus

3 references

7 November 2018

Regulation of wingless signaling by the CKI family in Drosophila limb development.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

7 November 2018

Developmental profiles of PERIOD and DOUBLETIME in Drosophila melanogaster ovary.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

7 November 2018

A Doubletime Nuclear Localization Signal Mediates an Interaction with Bride of Doubletime to Promote Circadian Function

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

cytoplasm

3 references

7 November 2018

Regulation of wingless signaling by the CKI family in Drosophila limb development.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

7 November 2018

Developmental profiles of PERIOD and DOUBLETIME in Drosophila melanogaster ovary.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

7 November 2018

Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

cell body

1 reference

8 April 2019

A Doubletime Nuclear Localization Signal Mediates an Interaction with Bride of Doubletime to Promote Circadian Function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

nucleus

Regulation of wingless signaling by the CKI family in Drosophila limb development.

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

Developmental profiles of PERIOD and DOUBLETIME in Drosophila melanogaster ovary.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

A Doubletime Nuclear Localization Signal Mediates an Interaction with Bride of Doubletime to Promote Circadian Function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

cytoplasm

Regulation of wingless signaling by the CKI family in Drosophila limb development.

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

Developmental profiles of PERIOD and DOUBLETIME in Drosophila melanogaster ovary.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

negative regulation of protein phosphorylation

biological process

1 reference

8 April 2019

Genome-wide RNAi screen for nuclear actin reveals a network of cofilin regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

protein phosphorylation

Invited review: Sleeping flies don't lie: the use of Drosophila melanogaster to study sleep and circadian rhythms

7 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

27 March 2018

From biological clock to biological rhythms

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

27 March 2018

Protein kinases and phosphatases in the Drosophila genome

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

27 March 2018

27 March 2018

Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

27 March 2018

Regulation of wingless signaling by the CKI family in Drosophila limb development.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

endocytosis

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

cell communication

1 reference

8 April 2019

Defective gap-junctional communication associated with imaginal disc overgrowth and degeneration caused by mutations of the dco gene in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

imaginal disc growth

1 reference

8 April 2019

Defective gap-junctional communication associated with imaginal disc overgrowth and degeneration caused by mutations of the dco gene in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

regulation of ecdysteroid secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

1 reference

8 April 2019

rhythmic behavior

1 reference

27 March 2018

Genetic analysis of the circadian system in Drosophila melanogaster and mammals

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

circadian rhythm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

7 references

8 April 2019

8 April 2019

Drosophila: genetics meets behaviour.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

A Doubletime Nuclear Localization Signal Mediates an Interaction with Bride of Doubletime to Promote Circadian Function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

Activating PER repressor through a DBT-directed phosphorylation switch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

eclosion rhythm

1 reference

27 March 2018

Clock mechanisms in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

regulation of cell shape

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

1 reference

16 July 2018

peptidyl-serine phosphorylation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

positive regulation of cell growth

1 reference

8 April 2019

The Drosophila casein kinase Iepsilon/delta Discs overgrown promotes cell survival via activation of DIAP1 expression.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

sleep

NAS

1 reference

27 March 2018

Drosophila: genetics meets behaviour.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

positive regulation of actin filament polymerization

NAS

1 reference

8 April 2019

Genome-wide RNAi screen for nuclear actin reveals a network of cofilin regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

16 July 2018

Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

regulation of protein import into nucleus

1 reference

27 March 2018

Genetic analysis of the circadian system in Drosophila melanogaster and mammals

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

regulation of circadian rhythm

4 references

8 April 2019

Drosophila DBT lacking protein kinase activity produces long-period and arrhythmic circadian behavioral and molecular rhythms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

DOUBLETIME plays a noncatalytic role to mediate CLOCK phosphorylation and repress CLOCK-dependent transcription within the Drosophila circadian clock

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

Casein kinase 1 promotes synchrony of the circadian clock network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

Drosophila and vertebrate casein kinase Idelta exhibits evolutionary conservation of circadian function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

locomotor rhythm

Drosophila: genetics meets behaviour.

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

NAS

27 March 2018

Drosophila DBT lacking protein kinase activity produces long-period and arrhythmic circadian behavioral and molecular rhythms

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

27 March 2018

Drosophila and vertebrate casein kinase Idelta exhibits evolutionary conservation of circadian function

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76324&geneProductId=UniProtKB:O76324

positive regulation of protein catabolic process

protein autophosphorylation

1 reference

8 April 2019

Drosophila and vertebrate casein kinase Idelta exhibits evolutionary conservation of circadian function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

rhythmic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

1 reference

8 April 2019

positive regulation of cell division

1 reference

8 April 2019

The Drosophila casein kinase Iepsilon/delta Discs overgrown promotes cell survival via activation of DIAP1 expression.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

cellular response to light stimulus

1 reference

8 April 2019

Translational regulation of the DOUBLETIME/CKIδ/ε kinase by LARK contributes to circadian period modulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

negative regulation of canonical Wnt signaling pathway

1 reference

8 April 2019

Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

positive regulation of Wnt signaling pathway

IGI

1 reference

8 April 2019

Systematic screening of a Drosophila ORF library in vivo uncovers Wnt/Wg pathway components

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

IGI

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

4 references

8 April 2019

8 April 2019

Regulation of wingless signaling by the CKI family in Drosophila limb development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

positive regulation of hippo signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

behavioral response to cocaine

1 reference

8 April 2019

Requirement of circadian genes for cocaine sensitization in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

peptidyl-threonine phosphorylation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of canonical Wnt signaling pathway

Regulation of wingless signaling by the CKI family in Drosophila limb development.

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76324

serine/threonine-protein kinase, active site

has part(s)

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference