Sevenless Dmel_CG18085 (Q29819070)

Immunoglobulin-like fold

1 reference

Protein kinase-like domain superfamily

1 reference

Six-bladed beta-propeller, TolB-like

1 reference

Fibronectin type III, protein family

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, receptor class II, conserved site, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

LDLR class B repeat, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

protein kinase activity

1 reference

8 April 2019

protein tyrosine kinase activity

4 references

1 January 2018

Protein kinases and phosphatases in the Drosophila genome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

1 January 2018

Structure and activity of the sevenless protein: a protein tyrosine kinase receptor required for photoreceptor development in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

transmembrane receptor protein tyrosine kinase activity

4 references

1 January 2018

Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

1 January 2018

Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

4 references

8 April 2019

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

8 April 2019

Disabled is a putative adaptor protein that functions during signaling by the sevenless receptor tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

8 April 2019

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

8 April 2019

Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

protein tyrosine kinase activity

3 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

5 June 2018

Structure and activity of the sevenless protein: a protein tyrosine kinase receptor required for photoreceptor development in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor

boss receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

transmembrane receptor protein kinase activity

1 reference

8 April 2019

Structure and activity of the sevenless protein: a protein tyrosine kinase receptor required for photoreceptor development in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

receptor tyrosine kinase

3 references

7 November 2018

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

transmembrane signaling receptor activity

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

transmembrane receptor protein tyrosine kinase activity

2 references

integral component of membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

integral component of plasma membrane

3 references

8 April 2019

Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

8 April 2019

Structure and activity of the sevenless protein: a protein tyrosine kinase receptor required for photoreceptor development in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

transmembrane receptor protein tyrosine kinase signaling pathway

biological process

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eye.

R7 cell fate commitment

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

8 April 2019

Cell fate in the Drosophila ommatidium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

8 April 2019

Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

8 April 2019

Competition between SOCS36E and Drk modulates Sevenless receptor tyrosine kinase activity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

Signal transduction pathway for anterior-posterior development in Drosophila

torso signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

anterior/posterior axis specification, embryo

NAS

1 reference

1 January 2018

Signal transduction pathway for anterior-posterior development in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

peptidyl-tyrosine phosphorylation

1 reference

1 January 2018

Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

establishment of ommatidial planar polarity

1 reference

5 June 2018

The role of the small GTPase Rap in Drosophila R7 photoreceptor specification

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

R8 cell fate specification

IMP

1 reference

5 June 2018

The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

1 reference

1 January 2018

R8 development in the Drosophila eye: a paradigm for neural selection and differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

positive regulation of R7 cell differentiation

NAS

1 reference

5 June 2018

Competition between SOCS36E and Drk modulates Sevenless receptor tyrosine kinase activity.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

positive regulation of photoreceptor cell differentiation

IMP

1 reference

5 June 2018

Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

protein phosphorylation

1 reference

8 April 2019

peptidyl-tyrosine autophosphorylation

1 reference

8 April 2019

Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

sevenless signaling pathway

5 references

21 June 2018

Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

21 June 2018

Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

21 June 2018

Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

21 June 2018

Prepattern in the developing Drosophila eye revealed by an activated torso--sevenless chimeric receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

21 June 2018

Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

sevenless signaling pathway

6 references

8 April 2019

Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

8 April 2019

Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

8 April 2019

Prepattern in the developing Drosophila eye revealed by an activated torso--sevenless chimeric receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

8 April 2019

Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

8 April 2019

Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

8 April 2019

Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

negative regulation of signal transduction

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

negative regulation of apoptotic process

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

positive regulation of ERK1 and ERK2 cascade

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13368&geneProductId=UniProtKB:P13368

regulation of TOR signaling

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13368

tyrosine-protein kinase, active site

has part(s)

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

tyrosine-protein kinase, receptor class II, conserved site

1 reference

protein kinase domain

1 reference

fibronectin type III

1 reference

LDLR class B repeat

1 reference

protein kinase, ATP binding site

1 reference