Nedd4 Dmel_CG42279 (Q29817872)

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Protein found in Drosophila melanogaster

CG42279-PH
CG42279-PK
Nedd4-PK
Nedd4-PH
DNedd4
CG42279-PJ
CG42279 gene product from transcript CG42279-RJ
Nedd4-PL
Nedd4-PJ
CG42279-PM
CG42279-PF
CG42279-PL
Nedd4-PE
Nedd4-PF
Nedd4-PG
Nedd4
CG42279-PI
Nedd4-PM
CG42279-PE
CG42279-PG
Nedd4-PI

Language	Label	Description	Also known as
English	Nedd4 Dmel_CG42279	Protein found in Drosophila melanogaster	CG42279-PH CG42279-PK Nedd4-PK Nedd4-PH DNedd4 CG42279-PJ CG42279 gene product from transcript CG42279-RJ Nedd4-PL Nedd4-PJ CG42279-PM CG42279-PF CG42279-PL Nedd4-PE Nedd4-PF Nedd4-PG Nedd4 CG42279-PI Nedd4-PM CG42279-PE CG42279-PG Nedd4-PI

Statements

1 reference

25 May 2022

UniProt protein ID

HECT, E3 ligase catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VVI3

WW domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VVI3

C2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VVI3

E3 ubiquitin-protein ligase, SMURF1 type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VVI3

HECT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

C2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

WW domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

ubiquitin-protein transferase activity

determination method

3 references

8 April 2019

Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

8 April 2019

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

determination method

1 reference

8 April 2019

Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

ubiquitin protein ligase activity

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

8 April 2019

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

determination method

4 references

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3

determination method

16 July 2018

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3

determination method

16 July 2018

Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3

determination method

16 July 2018

A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3

determination method

plasma membrane

determination method

1 reference

8 April 2019

A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

8 April 2019

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

8 April 2019

A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

8 April 2019

Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

biological process

positive regulation of receptor internalization

determination method

1 reference

8 April 2019

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

ubiquitin-dependent protein catabolic process

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3

determination method

Notch signaling pathway

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

determination method

1 reference

8 April 2019

Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

neuromuscular junction development

determination method

1 reference

8 April 2019

A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

imaginal disc-derived wing vein morphogenesis

determination method

1 reference

8 April 2019

The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

axon midline choice point recognition

determination method

protein ubiquitination

determination method

4 references

16 July 2018

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3

determination method

16 July 2018

Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3

determination method

16 July 2018

Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3

determination method

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3

determination method

receptor internalization

determination method

negative regulation of Notch signaling pathway

determination method

3 references

7 November 2018

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3

determination method

7 November 2018

Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3

determination method

7 November 2018

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3

determination method

positive regulation of synapse assembly

determination method

1 reference

8 April 2019

Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

positive regulation of cardioblast proliferation

determination method

1 reference

8 April 2019

The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

positive regulation of cardiac myofibril assembly

determination method

1 reference

8 April 2019

The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

protein polyubiquitination

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

protein ubiquitination

determination method

5 references

7 November 2018

Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3

determination method

7 November 2018

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3

determination method

7 November 2018

Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3

determination method

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3

determination method

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3

determination method

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

positive regulation of protein catabolic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

regulation of dendrite morphogenesis

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

negative regulation of sodium ion transmembrane transporter activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

negative regulation of smoothened signaling pathway

determination method

1 reference

8 April 2019

Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

protein ubiquitination

determination method

6 references

8 April 2019

Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

8 April 2019

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

8 April 2019

Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

8 April 2019

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

negative regulation of Notch signaling pathway

determination method

5 references

8 April 2019

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

8 April 2019

Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

8 April 2019

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

8 April 2019

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

8 April 2019

The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VVI3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VVI3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VVI3

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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