Toll Dmel_CG5490 (Q29817352)

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Protein found in Drosophila melanogaster
  • CG5490-PC
  • CG5490 gene product from transcript CG5490-RB
  • CG5490-PB
  • Tl
  • Tl-PC
  • protein toll precursor
  • Tl-PD
  • TOLL
  • Toll-1
  • Tl-PB
  • toll receptor
  • EP1051
  • CG5490-PD
edit
Language Label Description Also known as
English
Toll Dmel_CG5490
Protein found in Drosophila melanogaster
  • CG5490-PC
  • CG5490 gene product from transcript CG5490-RB
  • CG5490-PB
  • Tl
  • Tl-PC
  • protein toll precursor
  • Tl-PD
  • TOLL
  • Toll-1
  • Tl-PB
  • toll receptor
  • EP1051
  • CG5490-PD

Statements

molecular function
protein binding
determination method or standard
IPI
6 references
retrieved
8 April 2019
stated in
Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo
GOA
curator
UniProt
UniProt protein ID
P08953
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IPI
retrieved
8 April 2019
stated in
Drosophila MyD88 is an adapter in the Toll signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IPI
retrieved
8 April 2019
stated in
Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IPI
retrieved
8 April 2019
stated in
Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IPI
retrieved
8 April 2019
stated in
Tehao functions in the Toll pathway in Drosophila melanogaster: possible roles in development and innate immunity
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Spätzle.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IPI
cell component
plasma membrane
determination method or standard
IDA
IEA
TAS
6 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953
determination method or standard
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P08953
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953
determination method or standard
IEA
retrieved
1 January 2018
stated in
Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: importance of transmembrane signaling for dorsal-ventral pattern formation
GOA
curator
UniProt
UniProt protein ID
P08953
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953
determination method or standard
IDA
retrieved
1 January 2018
stated in
Mapping organelle proteins and protein complexes in Drosophila melanogaster
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953
determination method or standard
IDA
retrieved
1 January 2018
stated in
Plasma membrane polarity and compartmentalization are established before cellularization in the fly embryo
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953
determination method or standard
IDA
retrieved
1 January 2018
stated in
Endocytic pathway is required for Drosophila Toll innate immune signaling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953
determination method or standard
IDA
integral component of plasma membrane
determination method or standard
IBA
IDA
5 references
retrieved
8 April 2019
stated in
Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IDA
retrieved
8 April 2019
stated in
Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: importance of transmembrane signaling for dorsal-ventral pattern formation
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IDA
retrieved
8 April 2019
stated in
Endocytic pathway is required for Drosophila Toll innate immune signaling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IDA
retrieved
8 April 2019
stated in
Plasma membrane polarity and compartmentalization are established before cellularization in the fly embryo
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IBA
biological process
Toll signaling pathway
determination method or standard
IDA
IGI
IMP
TAS
12 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
TAS
retrieved
8 April 2019
stated in
Differential display of peptides induced during the immune response of Drosophila: a matrix-assisted laser desorption ionization time-of-flight mass spectrometry study
GOA
curator
UniProt
UniProt protein ID
P08953
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IMP
retrieved
8 April 2019
stated in
A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IMP
retrieved
8 April 2019
stated in
The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IMP
retrieved
8 April 2019
stated in
Toll-related receptors and the control of antimicrobial peptide expression in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IMP
retrieved
8 April 2019
stated in
Cactus protein degradation mediates Drosophila dorsal-ventral signaling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IMP
retrieved
8 April 2019
stated in
A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IMP
retrieved
8 April 2019
stated in
Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IMP
retrieved
8 April 2019
stated in
Functional interactions between the pelle kinase, Toll receptor, and tube suggest a mechanism for activation of dorsal.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IGI
retrieved
8 April 2019
stated in
Multimerization and interaction of Toll and Spätzle in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IDA
retrieved
8 April 2019
stated in
Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IDA
retrieved
8 April 2019
stated in
Cytokine Spatzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IDA
dorsal/ventral axis specification
determination method or standard
IGI
IMP
5 references
retrieved
8 April 2019
stated in
Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product
GOA
curator
UniProt
UniProt protein ID
P08953
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IMP
retrieved
8 April 2019
stated in
Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IMP
retrieved
8 April 2019
stated in
The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IMP
retrieved
8 April 2019
stated in
A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IMP
retrieved
8 April 2019
stated in
Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953
determination method or standard
IGI

Identifiers

 
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