Hedgehog Dmel_CG4637 (Q29814574)

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Protein found in Drosophila melanogaster
  • hh
  • PKC
  • hedgehog
  • CG4637-PB
  • CG4637 gene product from transcript CG4637-RB
  • moonrat
  • hh-PB
  • atypical
  • hedghog
  • bar-on-3
  • mirabile
edit
Language Label Description Also known as
English
Hedgehog Dmel_CG4637
Protein found in Drosophila melanogaster
  • hh
  • PKC
  • hedgehog
  • CG4637-PB
  • CG4637 gene product from transcript CG4637-RB
  • moonrat
  • hh-PB
  • atypical
  • hedghog
  • bar-on-3
  • mirabile

Statements

molecular function
cell component
extracellular region
determination method
IDA
IEA
NAS
TAS
6 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
TAS
retrieved
8 April 2019
stated in
Genetic control of cell proliferation and differentiation in Drosophila spermatogenesis
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
TAS
retrieved
8 April 2019
stated in
In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
TAS
retrieved
8 April 2019
stated in
Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila
GOA
curator
UniProt
UniProt protein ID
Q02936
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q02936
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IEA
retrieved
8 April 2019
stated in
Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
extracellular space
determination method
IBA
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
Secretion of the amino-terminal fragment of the hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q02936
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IEA
retrieved
8 April 2019
stated in
Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
retrieved
8 April 2019
stated in
Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
retrieved
8 April 2019
stated in
Quantitative analysis of Hedgehog gradient formation using an inducible expression system
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IBA
biological process
segment polarity determination
determination method
IEA
IEP
IMP
NAS
TAS
6 references
retrieved
24 April 2018
stated in
The evolution of arthropod segmentation mechanisms
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936
determination method
TAS
retrieved
24 April 2018
stated in
Generating patterns from fields of cells. Examples from Drosophila segmentation
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936
determination method
NAS
retrieved
24 April 2018
stated in
Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936
determination method
IMP
retrieved
24 April 2018
stated in
Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila
GOA
curator
UniProt
UniProt protein ID
Q02936
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936
determination method
IEP
retrieved
24 April 2018
stated in
Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication
GOA
curator
UniProt
UniProt protein ID
Q02936
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936
determination method
IEP
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q02936
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936
determination method
IEA
smoothened signaling pathway
determination method
IDA
IGI
IMP
TAS
14 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
TAS
retrieved
1 January 2018
stated in
Regulation of smoothened by Drosophila G-protein-coupled receptor kinases
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IMP
retrieved
1 January 2018
stated in
Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IMP
retrieved
1 January 2018
stated in
The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IMP
retrieved
1 January 2018
stated in
Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IGI
retrieved
1 January 2018
stated in
smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IGI
retrieved
1 January 2018
stated in
The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
retrieved
1 January 2018
stated in
The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
retrieved
1 January 2018
stated in
Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
retrieved
1 January 2018
stated in
The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
retrieved
1 January 2018
stated in
Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
retrieved
1 January 2018
stated in
PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
retrieved
1 January 2018
stated in
The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
retrieved
1 January 2018
stated in
Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
segment polarity determination
determination method
IEA
IEP
IMP
TAS
8 references
retrieved
8 April 2019
stated in
The evolution of arthropod segmentation mechanisms
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
TAS
retrieved
8 April 2019
stated in
The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IMP
retrieved
8 April 2019
stated in
smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IMP
retrieved
8 April 2019
stated in
Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IMP
retrieved
8 April 2019
stated in
Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IMP
retrieved
8 April 2019
stated in
Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila
GOA
curator
UniProt
UniProt protein ID
Q02936
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IEP
retrieved
8 April 2019
stated in
Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication
GOA
curator
UniProt
UniProt protein ID
Q02936
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IEP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q02936
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IEA
smoothened signaling pathway
determination method
IBA
IDA
IGI
IMP
TAS
15 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
TAS
retrieved
8 April 2019
stated in
The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IMP
retrieved
8 April 2019
stated in
Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IMP
retrieved
8 April 2019
stated in
Regulation of smoothened by Drosophila G-protein-coupled receptor kinases
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IMP
retrieved
8 April 2019
stated in
smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IGI
retrieved
8 April 2019
stated in
Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IGI
retrieved
8 April 2019
stated in
The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
retrieved
8 April 2019
stated in
PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
retrieved
8 April 2019
stated in
The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
retrieved
8 April 2019
stated in
The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
retrieved
8 April 2019
stated in
Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
retrieved
8 April 2019
stated in
Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
retrieved
8 April 2019
stated in
Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
retrieved
8 April 2019
stated in
The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936
determination method
IBA

Identifiers

 
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