Deadpan Dmel_CG8704 (Q29810954)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q26263

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Orange domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

9 May 2019

9 May 2019

Neural stem cell transcriptional networks highlight genes essential for nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

DNA-binding transcription factor activity

1 reference

9 May 2019

bHLH-O proteins balance the self-renewal and differentiation of Drosophila neural stem cells by regulating Earmuff expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

protein binding

IPI

1 reference

9 May 2019

Protein-protein interactions among components of theDrosophila primary sex determination signal

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

sequence-specific DNA binding

IPI

1 reference

9 May 2019

An Hdac1/Rpd3-Poised Circuit Balances Continual Self-Renewal and Rapid Restriction of Developmental Potential during Asymmetric Stem Cell Division

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

protein dimerization activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

1 reference

9 May 2019

sequence-specific double-stranded DNA binding

1 reference

9 May 2019

bHLH-O proteins balance the self-renewal and differentiation of Drosophila neural stem cells by regulating Earmuff expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

DNA-binding transcription repressor activity, RNA polymerase II-specific

Transcriptional regulation of the Sex-lethal gene by helix-loop-helix proteins

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q26263&geneProductId=UniProtKB:Q26263

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q26263&geneProductId=UniProtKB:Q26263

9 May 2019

Transcriptional regulation of the Sex-lethal gene by helix-loop-helix proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

transcription corepressor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

transcription factor binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

sequence-specific DNA binding

sequence-specific double-stranded DNA binding

bHLH-O proteins balance the self-renewal and differentiation of Drosophila neural stem cells by regulating Earmuff expression

3 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q26263&geneProductId=UniProtKB:Q26263

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q26263&geneProductId=UniProtKB:Q26263

31 January 2018

31 January 2018

deadpan, an essential pan-neural gene in Drosophila, encodes a helix-loop-helix protein similar to the hairy gene product

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q26263&geneProductId=UniProtKB:Q26263

nucleus

bHLH-O proteins balance the self-renewal and differentiation of Drosophila neural stem cells by regulating Earmuff expression

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

9 May 2019

9 May 2019

deadpan, an essential pan-neural gene in Drosophila, encodes a helix-loop-helix protein similar to the hairy gene product

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

negative regulation of transcription by RNA polymerase II

biological process

positive regulation of neuroblast proliferation

The bHLH repressor Deadpan regulates the self-renewal and specification of Drosophila larval neural stem cells independently of Notch

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

9 May 2019

The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

9 May 2019

bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

9 May 2019

The bantam microRNA acts through Numb to exert cell growth control and feedback regulation of Notch in tumor-forming stem cells in the Drosophila brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

9 May 2019

FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

9 May 2019

The bHLH repressor Deadpan regulates the self-renewal and specification of Drosophila larval neural stem cells independently of Notch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q26263&geneProductId=UniProtKB:Q26263

1 reference

31 January 2018

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

1 reference

9 May 2019

Notch signaling pathway

1 reference

31 January 2018

The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q26263&geneProductId=UniProtKB:Q26263

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

1 reference

9 May 2019

nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

1 reference

9 May 2019

sex-determination system

1 reference

7 November 2018

Runt and Lozenge function in Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q26263&geneProductId=UniProtKB:Q26263

sex determination, establishment of X:A ratio

Structure, function and evolution of sex-determining systems in Dipteran insects

3 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q26263&geneProductId=UniProtKB:Q26263

7 November 2018

deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q26263&geneProductId=UniProtKB:Q26263

7 November 2018

deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q26263&geneProductId=UniProtKB:Q26263

dosage compensation

1 reference

9 May 2019

deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

adult locomotory behavior

1 reference

9 May 2019

deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

larval locomotory behavior

1 reference

9 May 2019

deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

negative regulation of gene expression

1 reference

9 May 2019

bHLH-O proteins balance the self-renewal and differentiation of Drosophila neural stem cells by regulating Earmuff expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

neuroblast development

1 reference

9 May 2019

The bHLH repressor Deadpan regulates the self-renewal and specification of Drosophila larval neural stem cells independently of Notch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q26263&geneProductId=UniProtKB:Q26263

1 reference

31 January 2018

positive regulation of mitotic nuclear division

1 reference

9 May 2019

The pan-neural bHLH proteins DEADPAN and ASENSE regulate mitotic activity and cdk inhibitor dacapo expression in the Drosophila larval optic lobes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

negative regulation of transcription, DNA-templated

1 reference

7 November 2018

Structure, function and evolution of sex-determining systems in Dipteran insects

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q26263&geneProductId=UniProtKB:Q26263

regulation of neuroblast proliferation

bHLH-O proteins balance the self-renewal and differentiation of Drosophila neural stem cells by regulating Earmuff expression

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

9 May 2019

An Hdac1/Rpd3-Poised Circuit Balances Continual Self-Renewal and Rapid Restriction of Developmental Potential during Asymmetric Stem Cell Division

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

9 May 2019

bHLH-O proteins balance the self-renewal and differentiation of Drosophila neural stem cells by regulating Earmuff expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

9 May 2019

An Hdac1/Rpd3-Poised Circuit Balances Continual Self-Renewal and Rapid Restriction of Developmental Potential during Asymmetric Stem Cell Division

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

9 May 2019

Earmuff restricts progenitor cell potential by attenuating the competence to respond to self-renewal factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

somitogenesis

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

Notch signaling pathway

regulation of neurogenesis

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

Notch signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

sex determination, establishment of X:A ratio

negative regulation of transcription by RNA polymerase II

bHLH-O proteins balance the self-renewal and differentiation of Drosophila neural stem cells by regulating Earmuff expression

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

9 May 2019

Transcriptional regulation of the Sex-lethal gene by helix-loop-helix proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

anterior/posterior pattern specification

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q26263

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q26263

Myc-type, basic helix-loop-helix (bHLH) domain

1 reference

InterPro Release 71.0