Argos Dmel_CG4531 (Q29656628)

http://www.ebi.ac.uk/interpro/protein/Q00805

InterPro Release 71.0

reference URL

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

identical protein binding

IPI

1 reference

8 April 2019

Structural basis for EGFR ligand sequestration by Argos

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

receptor antagonist activity

IPI

Patterning the fly eye: the role of apoptosis

3 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00805&geneProductId=UniProtKB:Q00805

31 January 2018

Signaling survival: how axons rescue their glia

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00805&geneProductId=UniProtKB:Q00805

31 January 2018

Epidermal growth factor receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00805&geneProductId=UniProtKB:Q00805

epidermal growth factor receptor binding

receptor antagonist activity

Localized activation of RTK/MAPK pathways during Drosophila development

4 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00805&geneProductId=UniProtKB:Q00805

31 January 2018

Epidermal growth factor receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00805&geneProductId=UniProtKB:Q00805

31 January 2018

The argos gene encodes a diffusible factor that regulates cell fate decisions in the Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00805&geneProductId=UniProtKB:Q00805

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00805&geneProductId=UniProtKB:Q00805

31 January 2018

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

1 reference

8 April 2019

extracellular space

1 reference

8 April 2019

Inhibition of Drosophila EGF receptor activation by the secreted protein Argos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

biological process

eye development

1 reference

8 April 2019

Atrophin contributes to the negative regulation of epidermal growth factor receptor signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

1 reference

8 April 2019

eye-antennal disc morphogenesis

1 reference

8 April 2019

Epithelial cell adhesion in the developing Drosophila retina is regulated by Atonal and the EGF receptor pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

wing disc morphogenesis

1 reference

8 April 2019

Egfr/Ras pathway mediates interactions between peripodial and disc proper cells in Drosophila wing discs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

imaginal disc-derived wing vein specification

1 reference

8 April 2019

MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

imaginal disc-derived wing morphogenesis

haltere development

1 reference

8 April 2019

Negative regulation of Egfr/Ras pathway by Ultrabithorax during haltere development in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

visual perception

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

1 reference

8 April 2019

negative regulation of cell fate specification

1 reference

31 January 2018

A genetic analysis of the Drosophila closely linked interacting genes bulge, argos and soba.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00805&geneProductId=UniProtKB:Q00805

ommatidial rotation

1 reference

8 April 2019

Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

ovarian follicle cell development

1 reference

31 January 2018

Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00805&geneProductId=UniProtKB:Q00805

genital disc development

1 reference

8 April 2019

Allocation and specification of the genital disc precursor cells in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

negative regulation of epidermal growth factor receptor signaling pathway

The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis

4 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00805&geneProductId=UniProtKB:Q00805

31 January 2018

Localized activation of RTK/MAPK pathways during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00805&geneProductId=UniProtKB:Q00805

31 January 2018

Signaling by the Drosophila epidermal growth factor receptor pathway during development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00805&geneProductId=UniProtKB:Q00805

31 January 2018

Epidermal growth factor receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00805&geneProductId=UniProtKB:Q00805

establishment of ommatidial planar polarity

1 reference

31 January 2018

Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation?

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00805&geneProductId=UniProtKB:Q00805

positive regulation of apoptotic process

1 reference

8 April 2019

Control of compartment size by an EGF ligand from neighboring cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

negative regulation of cell differentiation

1 reference

31 January 2018

Mutations modulating the Argos-regulated signaling pathway in Drosophila eye development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00805&geneProductId=UniProtKB:Q00805

negative regulation of neurogenesis

1 reference

8 April 2019

Conserved miR-8/miR-200 defines a glial niche that controls neuroepithelial expansion and neuroblast transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

response to stimulus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

1 reference

8 April 2019

oenocyte delamination

1 reference

8 April 2019

EGF receptor signaling regulates pulses of cell delamination from the Drosophila ectoderm.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

extracellular negative regulation of signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00805&geneProductId=UniProtKB:Q00805

1 reference

1 January 2018

Gene Ontology Consortium

reference URL

negative regulation of stem cell differentiation

1 reference

8 April 2019

gone early, a novel germline factor, ensures the proper size of the stem cell precursor pool in the Drosophila ovary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

negative regulation of epidermal growth factor-activated receptor activity

4 references

8 April 2019

Argos inhibits epidermal growth factor receptor signalling by ligand sequestration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

8 April 2019

Inhibition of Drosophila EGF receptor activation by the secreted protein Argos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

8 April 2019

Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

8 April 2019

The interaction between the Drosophila secreted protein argos and the epidermal growth factor receptor inhibits dimerization of the receptor and binding of secreted spitz to the receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

anterior/posterior axis specification

1 reference

8 April 2019

Misexpression of argos, an inhibitor of EGFR signaling in oogenesis, leads to the production of bicephalic, ventralized, and lateralized Drosophila melanogaster eggs.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

dorsal/ventral axis specification

1 reference

8 April 2019

Misexpression of argos, an inhibitor of EGFR signaling in oogenesis, leads to the production of bicephalic, ventralized, and lateralized Drosophila melanogaster eggs.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

negative regulation of epidermal growth factor receptor signaling pathway

EGF domain swap converts a drosophila EGF receptor activator into an inhibitor

11 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

8 April 2019

Misexpression of argos, an inhibitor of EGFR signaling in oogenesis, leads to the production of bicephalic, ventralized, and lateralized Drosophila melanogaster eggs.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

8 April 2019

Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

8 April 2019

Echinoid is essential for regulation of Egfr signaling and R8 formation during Drosophila eye development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

8 April 2019

A Drosophila analogue of v-Cbl is a dominant-negative oncoprotein in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

8 April 2019

Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

8 April 2019

Inhibition of Drosophila EGF receptor activation by the secreted protein Argos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

8 April 2019

Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-alpha homolog Spitz

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

8 April 2019

Argos inhibits epidermal growth factor receptor signalling by ligand sequestration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

8 April 2019

Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

8 April 2019

The interaction between the Drosophila secreted protein argos and the epidermal growth factor receptor inhibits dimerization of the receptor and binding of secreted spitz to the receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805

negative regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

EGF domain swap converts a drosophila EGF receptor activator into an inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00805