EGF-ERBB signalling: towards the systems level (Q29619032)

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26 December 2019

review article

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title

EGF-ERBB signalling: towards the systems level (English)

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30 April 2017

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26 December 2019

1

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26 December 2019

author name string

Yosef Yarden

series ordinal

2

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26 December 2019

language of work or name

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30 April 2017

publication date

1 July 2006

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Nature Reviews Molecular Cell Biology

26 December 2019

published in

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volume

7

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26 December 2019

issue

7

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26 December 2019

page(s)

505-516

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The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors

26 December 2019

cites work

1 reference

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity

31 March 2020

1 reference

Untangling the ErbB signalling network

31 March 2020

1 reference

Robustness of cellular functions

31 March 2020

1 reference

31 March 2020

Biological robustness

1 reference

Phosphotyrosine interactome of the ErbB-receptor kinase family

31 March 2020

1 reference

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

31 March 2020

1 reference

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

31 March 2020

1 reference

Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype

31 March 2020

1 reference

Strain-dependent epithelial defects in mice lacking the EGF receptor

31 March 2020

1 reference

A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor

31 March 2020

1 reference

Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation.

31 March 2020

1 reference

Growth retardation, duodenal lesions, and aberrant ileum architecture in triple null mice lacking EGF, amphiregulin, and TGF-alpha

31 March 2020

1 reference

TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice.

31 March 2020

1 reference

The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase

31 March 2020

1 reference

A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor

31 March 2020

1 reference

A quantitative protein interaction network for the ErbB receptors using protein microarrays

31 March 2020

1 reference

All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired

31 March 2020

1 reference

ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors.

31 March 2020

1 reference

Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers

31 March 2020

1 reference

The C-terminus of the kinase-defective neuregulin receptor ErbB-3 confers mitogenic superiority and dictates endocytic routing

31 March 2020

1 reference

Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types

31 March 2020

1 reference

Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4

31 March 2020

1 reference

Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase

31 March 2020

1 reference

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

31 March 2020

1 reference

Multiple essential functions of neuregulin in development

31 March 2020

1 reference

Requirement for neuregulin receptor erbB2 in neural and cardiac development

31 March 2020

1 reference

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

31 March 2020

1 reference

Severe neuropathies in mice with targeted mutations in the ErbB3 receptor

31 March 2020

1 reference

An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

31 March 2020

1 reference

Oligomerization of epidermal growth factor receptors on A431 cells studied by time-resolved fluorescence imaging microscopy. A stereochemical model for tyrosine kinase receptor activation

31 March 2020

1 reference

Two EGF molecules contribute additively to stabilization of the EGFR dimer

31 March 2020

1 reference

Single-molecule imaging of EGFR signalling on the surface of living cells

31 March 2020

1 reference

Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain

31 March 2020

1 reference

Ligand-induced dimer-tetramer transition during the activation of the cell surface epidermal growth factor receptor-A multidimensional microscopy analysis

31 March 2020

1 reference

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

31 March 2020

1 reference

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

31 March 2020

1 reference

The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors

31 March 2020

1 reference

Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics

31 March 2020

1 reference

Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules

31 March 2020

1 reference

The connectivity structure, giant strong component and centrality of metabolic networks

31 March 2020

1 reference

31 March 2020

1 reference

Phenotypic plasticity in the interactions and evolution of species

31 March 2020

1 reference

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

31 March 2020

1 reference

A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling

31 March 2020

1 reference

Grb2 regulates internalization of EGF receptors through clathrin-coated pits

31 March 2020

1 reference

Feedback control of intercellular signalling in development

31 March 2020

1 reference

Analysis of the transcriptional program induced by Raf in epithelial cells

31 March 2020

1 reference

Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion

31 March 2020

1 reference

Trafficking of the ErbB receptors and its influence on signaling

31 March 2020

1 reference

The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions

31 March 2020

1 reference

Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum

31 March 2020

1 reference

Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling

31 March 2020

1 reference

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway

31 March 2020

1 reference

Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the activation of Raf.

31 March 2020

1 reference

Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops

31 March 2020

1 reference

The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases

31 March 2020

1 reference

LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation

31 March 2020

1 reference

Mig-6 is a negative regulator of the epidermal growth factor receptor signal

31 March 2020

1 reference

Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control

31 March 2020

1 reference

Feedback inhibition by RALT controls signal output by the ErbB network

31 March 2020

1 reference

Hsp90 as a capacitor for morphological evolution

31 March 2020

1 reference

31 March 2020

Heat shock protein 90.

1 reference

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

31 March 2020

1 reference

Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation

31 March 2020

1 reference

Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex.

31 March 2020

1 reference

Control of epidermal growth factor receptor endocytosis by receptor dimerization, rather than receptor kinase activation

31 March 2020

1 reference

Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain

31 March 2020

1 reference

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

31 March 2020

1 reference

Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

31 March 2020

1 reference

Requirement for the adapter protein GRB2 in EGF receptor endocytosis

31 March 2020

1 reference

The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

31 March 2020

1 reference

Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

31 March 2020

1 reference

Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4.

31 March 2020

1 reference

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

31 March 2020

1 reference

Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding

31 March 2020

1 reference

Receptor downregulation and multivesicular-body sorting

31 March 2020

1 reference

Endosomal signaling of epidermal growth factor receptor stimulates signal transduction pathways leading to cell survival

31 March 2020

1 reference

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

31 March 2020

1 reference

Selective cleavage of the heregulin receptor ErbB-4 by protein kinase C activation

31 March 2020

1 reference

The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone

31 March 2020

1 reference

WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus

31 March 2020

1 reference

Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level

31 March 2020

1 reference

WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function

31 March 2020

1 reference

Effective intravenous therapy of murine pulmonary metastases with an oncolytic herpes virus expressing interleukin 12

31 March 2020

1 reference

Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

31 March 2020

1 reference

Cell-signalling dynamics in time and space

31 March 2020

1 reference

Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway

31 March 2020

1 reference

A steady state model for analyzing the cellular binding, internalization and degradation of polypeptide ligands

31 March 2020

1 reference

Mathematical model for the effects of epidermal growth factor receptor trafficking dynamics on fibroblast proliferation responses

31 March 2020

1 reference

Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor

31 March 2020

1 reference

Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors

31 March 2020

1 reference

An integrated model of epidermal growth factor receptor trafficking and signal transduction

31 March 2020

1 reference

Self-organization of polarized cell signaling via autocrine circuits: computational model analysis

31 March 2020

1 reference

Engineering epidermal growth factor for enhanced mitogenic potency

31 March 2020

1 reference

Pathogenic poxviruses reveal viral strategies to exploit the ErbB signaling network

31 March 2020

1 reference

Analysis of receptor internalization as a mechanism for modulating signal transduction.

31 March 2020

1 reference

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

31 March 2020

1 reference

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

31 March 2020

1 reference

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

31 March 2020

1 reference

Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255.

31 March 2020

1 reference

Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

31 March 2020

1 reference

ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines

31 March 2020

1 reference

Somatic mutations of the HER2 kinase domain in lung adenocarcinomas.

31 March 2020

1 reference

Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails

31 March 2020

1 reference

Clinical significance of EGFR amplification and the aberrant EGFRvIII transcript in conventionally treated astrocytic gliomas.

31 March 2020

1 reference

The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

31 March 2020

1 reference

EGFR and cancer prognosis

31 March 2020

1 reference

Targeting epidermal growth factor receptor in head and neck cancer

31 March 2020

1 reference

The Her-2/neu gene and protein in breast cancer 2003: biomarker and target of therapy

31 March 2020

1 reference

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

31 March 2020

1 reference

Constitutive neuregulin-1/ErbB signaling contributes to human vestibular schwannoma proliferation.

31 March 2020

1 reference

The epidermal growth factor system in Caenorhabditis elegans

31 March 2020

1 reference

Signaling by the Drosophila epidermal growth factor receptor pathway during development

31 March 2020

1 reference

Evolutionary analysis of the ErbB receptor and ligand families

31 March 2020

1 reference

Computer simulated evolution of a network of cell-signaling molecules

31 March 2020

1 reference

Cancer robustness: Tumour tactics

31 March 2020

1 reference

Highly Optimized Tolerance: Robustness and Design in Complex Systems

31 March 2020

1 reference

Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets

31 March 2020

1 reference

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

31 March 2020

1 reference

Synergistic down-regulation of receptor tyrosine kinases by combinations of mAbs: implications for cancer immunotherapy

31 March 2020

1 reference

Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways

31 March 2020

1 reference

Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy

31 March 2020

1 reference

Augmentation of a humanized anti-HER2 mAb 4D5 induced growth inhibition by a human-mouse chimeric anti-EGF receptor mAb C225

31 March 2020

1 reference

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

31 March 2020

1 reference

Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer

31 March 2020

1 reference

Clinical results of transhiatal esophagectomy for carcinoma of the lower thoracic esophagus according to biological markers

31 March 2020

1 reference

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26 December 2019

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