Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression (Q29617473)

Europe PubMed Central

title

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression (English)

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30 April 2017

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Fingar DC

1

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30 April 2017

Blenis J

series ordinal

2

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30 April 2017

language of work or name

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30 April 2017

publication date

19 April 2004

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30 April 2017

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30 April 2017

volume

23

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15094765

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issue

18

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30 April 2017

page(s)

3151-71

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Immunopharmacology of rapamycin

30 April 2017

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Identification and characterization of a mitogen-activated S6 kinase

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Coordination of growth with cell division in the yeast Saccharomyces cerevisiae

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Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity

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Sirolimus-Eluting Stents versus Standard Stents in Patients with Stenosis in a Native Coronary Artery

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B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

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An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten /- mice

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21 January 2018

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Genetics: influence of TOR kinase on lifespan in C. elegans

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7 January 2021

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7 January 2021

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7 January 2021

Control of p70 s6 kinase by kinase activity of FRAP in vivo

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7 January 2021

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

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7 January 2021

The phosphoinositide 3-kinase pathway

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7 January 2021

Phospholipase D confers rapamycin resistance in human breast cancer cells

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7 January 2021

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

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7 January 2021

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

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7 January 2021

The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.

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7 January 2021

A nutrient sensor mechanism controls Drosophila growth.

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7 January 2021

Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression

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7 January 2021

Mammalian TOR: a homeostatic ATP sensor

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7 January 2021

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

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7 January 2021

Inhibition of intimal thickening after balloon angioplasty in porcine coronary arteries by targeting regulators of the cell cycle

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7 January 2021

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

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7 January 2021

Regulation of translation initiation by FRAP/mTOR

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7 January 2021

The Hallmarks of Cancer

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7 January 2021

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

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7 January 2021

AMP-activated protein kinase: the energy charge hypothesis revisited

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7 January 2021

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

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7 January 2021

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

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7 January 2021

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

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7 January 2021

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

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7 January 2021

Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation

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7 January 2021

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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7 January 2021

TSC2 mediates cellular energy response to control cell growth and survival

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7 January 2021

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7 January 2021

A C. elegans mutant that lives twice as long as wild type

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7 January 2021

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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7 January 2021

A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

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7 January 2021

A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

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7 January 2021

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

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7 January 2021

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

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7 January 2021

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

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7 January 2021

PHAS-I as a link between mitogen-activated protein kinase and translation initiation

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7 January 2021

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

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7 January 2021

Rheb fills a GAP between TSC and TOR.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207542

7 January 2021

United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling

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7 January 2021

Drosophila S6 kinase: a regulator of cell size

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7 January 2021

Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies

1 reference

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7 January 2021

Coordination of growth and cell division in the Drosophila wing

1 reference

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7 January 2021

Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice

1 reference

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7 January 2021

The ATRs, ATMs, and TORs are giant HEAT repeat proteins.

1 reference

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7 January 2021

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207542

7 January 2021

Phosphorylation and activation of p70s6k by PDK1

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207542

7 January 2021

Modulation of apoptosis, proliferation, and p27 expression in a porcine coronary angioplasty model

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207542

7 January 2021

Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207542

7 January 2021

Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207542

7 January 2021

Insulin signalling and the regulation of glucose and lipid metabolism

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207542

7 January 2021

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207542

7 January 2021

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207542

7 January 2021

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207542

7 January 2021

The coupling of cell growth to the cell cycle.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207542

7 January 2021

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207542

7 January 2021

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207542

7 January 2021

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207542

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207542

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15094765

30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1016470855

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1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15094765

PubMed publication ID

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017