Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics (Q29616134)

Europe PubMed Central

title

Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics (English)

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30 April 2017

author name string

Maquat LE

series ordinal

1

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15040442

30 April 2017

language of work or name

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30 April 2017

publication date

February 2004

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Nature Reviews Molecular Cell Biology

30 April 2017

published in

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30 April 2017

volume

5

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30 April 2017

issue

2

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30 April 2017

page(s)

89-99

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Quality control of mRNA function

30 April 2017

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A perfect message: RNA surveillance and nonsense-mediated decay

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Mechanisms of mRNA surveillance in eukaryotes

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Looking at mRNA decay pathways through the window of molecular evolution

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Unstable β-globin mRNA in mRNA-deficient β0 thalassemia

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mRNA-deficient beta o-thalassemia results from a single nucleotide deletion.

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Gene structure prediction and alternative splicing analysis using genomically aligned ESTs

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smg mutants affect the expression of alternatively spliced SR protein mRNAs in Caenorhabditis elegans

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Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA.

31 March 2020

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Nonsense-mediated decay of mRNA for the selenoprotein phospholipid hydroperoxide glutathione peroxidase is detectable in cultured cells but masked or inhibited in rat tissues

31 March 2020

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Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans

31 March 2020

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Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability

31 March 2020

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T cell receptor-beta mRNA splicing: regulation of unusual splicing intermediates

31 March 2020

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A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitro

31 March 2020

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Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection

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Efficient cleavage of ribosome-associated poly(A)-binding protein by enterovirus 3C protease

31 March 2020

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Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.

31 March 2020

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Binary specification of nonsense codons by splicing and cytoplasmic translation

31 March 2020

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T cell receptor (TCR) mini-gene mRNA expression regulated by nonsense codons: a nuclear-associated translation-like mechanism

31 March 2020

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Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells

31 March 2020

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Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance

31 March 2020

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At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation

31 March 2020

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Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm

31 March 2020

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Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position

31 March 2020

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Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.

31 March 2020

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Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.

31 March 2020

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The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling

31 March 2020

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A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance

31 March 2020

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Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay

31 March 2020

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The human intronless melanocortin 4-receptor gene is NMD insensitive

31 March 2020

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Boundary-independent polar nonsense-mediated decay

31 March 2020

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Computational modeling and experimental analysis of nonsense-mediated decay in yeast

31 March 2020

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The RNA binding protein Pub1 modulates the stability of transcripts containing upstream open reading frames

31 March 2020

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Abnormally spliced beta-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay

31 March 2020

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Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs

31 March 2020

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The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay

31 March 2020

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Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice

31 March 2020

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A gene-targeted mouse model for familial hypobetalipoproteinemia. Low levels of apolipoprotein B mRNA in association with a nonsense mutation in exon 26 of the apolipoprotein B gene

31 March 2020

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The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

31 March 2020

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A coactivator of pre-mRNA splicing

31 March 2020

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Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing

31 March 2020

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Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm

31 March 2020

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Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex

31 March 2020

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The protein Mago provides a link between splicing and mRNA localization.

31 March 2020

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The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes

31 March 2020

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The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans

31 March 2020

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The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in Drosophila

31 March 2020

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Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly

31 March 2020

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5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly

31 March 2020

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The Y14 protein communicates to the cytoplasm the position of exon-exon junctions

31 March 2020

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Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20

31 March 2020

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Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1

31 March 2020

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Translation is required to remove Y14 from mRNAs in the cytoplasm

31 March 2020

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Splicing is required for rapid and efficient mRNA export in metazoans

31 March 2020

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The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human

31 March 2020

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The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates

31 March 2020

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The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

31 March 2020

1 reference

Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export

31 March 2020

1 reference

Structure of the Y14-Magoh core of the exon junction complex

31 March 2020

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Crystal structure of theDrosophilaMago nashi–Y14 complex

31 March 2020

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A novel mode of RBD-protein recognition in the Y14–Mago complex

31 March 2020

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Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport

31 March 2020

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A conserved mRNA export machinery coupled to pre-mRNA splicing

31 March 2020

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REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export

31 March 2020

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A quantitative analysis of intron effects on mammalian gene expression

31 March 2020

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Exon junction complexes mediate the enhancing effect of splicing on mRNA expression

31 March 2020

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Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA

31 March 2020

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SR splicing factors serve as adapter proteins for TAP-dependent mRNA export

31 March 2020

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Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon

31 March 2020

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Y14 and hUpf3b form an NMD-activating complex

31 March 2020

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Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities

31 March 2020

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A nuclear cap binding protein complex involved in pre-mRNA splicing

31 March 2020

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The Role of the Cap Structure in RNA Processing and Nuclear Export

31 March 2020

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A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export

31 March 2020

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7The yeast mRNA-binding protein Npl3p interacts with the cap-binding complex

31 March 2020

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A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus

31 March 2020

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eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

31 March 2020

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Nuclear eukaryotic initiation factor 4E (eIF4E) colocalizes with splicing factors in speckles

31 March 2020

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NASty effects on fibrillin pre-mRNA splicing: another case of ESE does it, but proposals for translation-dependent splice site choice live on.

31 March 2020

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Nonsense-associated altered splicing: a frame-dependent response distinct from nonsense-mediated decay

31 March 2020

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Nuclear translation: what is the evidence?

31 March 2020

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Coupled transcription and translation within nuclei of mammalian cells.

31 March 2020

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Precursor RNAs harboring nonsense codons accumulate near the site of transcription

31 March 2020

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Intranuclear degradation of nonsense codon-containing mRNA

31 March 2020

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Ribosome components are associated with sites of transcription.

31 March 2020

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Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm

31 March 2020

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Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA

31 March 2020

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Alternatively spliced TCR mRNA induced by disruption of reading frame.

31 March 2020

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Nuclear protein synthesis: a re-evaluation

31 March 2020

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Looking for nuclear translation using xenopus oocytes

31 March 2020

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Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates

31 March 2020

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A pre-mRNA-binding protein accompanies the RNA from the gene through the nuclear pores and into polysomes

31 March 2020

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Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts

31 March 2020

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A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells

31 March 2020

1 reference

Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay

31 March 2020

1 reference

Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway

31 March 2020

1 reference

Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein

31 March 2020

1 reference

Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)

31 March 2020

1 reference

Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.

31 March 2020

1 reference

Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes

31 March 2020

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SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast

31 March 2020

1 reference

Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein

31 March 2020

1 reference

Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

31 March 2020

1 reference

SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A.

31 March 2020

1 reference

Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways

31 March 2020

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The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

31 March 2020

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The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts

31 March 2020

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Nonsense-mediated decay mutants do not affect programmed -1 frameshifting

31 March 2020

1 reference

Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells

31 March 2020

1 reference

Nonsense-mediated mRNA decay: insights into mechanism from the cellular abundance of human Upf1, Upf2, Upf3, and Upf3X proteins

31 March 2020

1 reference

T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts

31 March 2020

1 reference

Identification of delta helicase as the bovine homolog of HUPF1: demonstration of an interaction with the third subunit of DNA polymerase delta

31 March 2020

1 reference

Purification and characterization of .delta. helicase from fetal calf thymus

31 March 2020

1 reference

A link between RNA interference and nonsense-mediated decay in Caenorhabditis elegans

31 March 2020

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A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed

31 March 2020

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mRNAs encoding telomerase components and regulators are controlled by UPF genes in Saccharomyces cerevisiae

31 March 2020

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Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover

31 March 2020

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Premature translational termination triggers mRNA decapping

31 March 2020

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Aberrant mRNAs with extended 3' UTRs are substrates for rapid degradation by mRNA surveillance

31 March 2020

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An NMD pathway in yeast involving accelerated deadenylation and exosome-mediated 3'-->5' degradation

31 March 2020

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Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay

31 March 2020

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Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures

31 March 2020

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Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway

31 March 2020

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Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products

31 March 2020

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Beta -Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon

31 March 2020

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An endonuclease activity similar to Xenopus PMR1 catalyzes the degradation of normal and nonsense-containing human beta-globin mRNA in erythroid cells.

31 March 2020

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Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII

31 March 2020

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The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon

31 March 2020

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Gene products that promote mRNA turnover in Saccharomyces cerevisiae

31 March 2020

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mRNA surveillance by the Caenorhabditis elegans smg genes

31 March 2020

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The hDcp2 protein is a mammalian mRNA decapping enzyme

31 March 2020

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Functional characterization of the mammalian mRNA decapping enzyme hDcp2

31 March 2020

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mRNA decay enzymes: decappers conserved between yeast and mammals

31 March 2020

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A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates

31 March 2020

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Cloning and mapping of the XRN2 gene to human chromosome 20p11.1-p11.2

31 March 2020

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Cap-dependent deadenylation of mRNA

31 March 2020

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Poly(A) tail shortening by a mammalian poly(A)-specific 3'-exoribonuclease

31 March 2020

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The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases

31 March 2020

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AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

31 March 2020

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Identification of in vivo mRNA decay intermediates corresponding to sites of in vitro cleavage by polysomal ribonuclease 1.

31 March 2020

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Initial sequencing and analysis of the human genome

31 March 2020

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The Sequence of the Human Genome

31 March 2020

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Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex

31 March 2020

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15040442

31 March 2020

Identifiers

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

498987

Dimensions Publication ID

1042225606

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OpenCitations bibliographic resource ID

498987

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