Mitochondria and cell death: outer membrane permeabilization and beyond (Q29615459)

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9 February 2020

review article

1 reference

title

Mitochondria and cell death: outer membrane permeabilization and beyond (English)

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30 April 2017

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9 February 2020

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9 February 2020

Douglas R. Green

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2

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9 February 2020

author name string

Tait SW

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30 April 2017

Green DR

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language of work or name

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30 April 2017

publication date

4 August 2010

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Nature Reviews Molecular Cell Biology

9 February 2020

published in

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9 February 2020

volume

11

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issue

9

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9 February 2020

page(s)

621-632

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

9 February 2020

cites work

1 reference

Apoptosis: controlled demolition at the cellular level

31 March 2020

1 reference

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

31 March 2020

1 reference

XIAP discriminates between type I and type II FAS-induced apoptosis

31 March 2020

1 reference

Living with death: the evolution of the mitochondrial pathway of apoptosis in animals.

31 March 2020

1 reference

Mitochondrial disruption in Drosophila apoptosis

31 March 2020

1 reference

DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans

31 March 2020

1 reference

Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2.

31 March 2020

1 reference

31 March 2020

The BCL-2 family reunion

1 reference

The BCL-2 protein family: opposing activities that mediate cell death

31 March 2020

1 reference

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

31 March 2020

1 reference

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

31 March 2020

1 reference

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

31 March 2020

1 reference

A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax.

31 March 2020

1 reference

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

31 March 2020

1 reference

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

31 March 2020

1 reference

BAX activation is initiated at a novel interaction site

31 March 2020

1 reference

The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site

31 March 2020

1 reference

Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices

31 March 2020

1 reference

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

31 March 2020

1 reference

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

31 March 2020

1 reference

Dynamics and structure of the Bax-Bak complex responsible for releasing mitochondrial proteins during apoptosis

31 March 2020

1 reference

Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation.

31 March 2020

1 reference

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

31 March 2020

1 reference

An intracellular wave of cytochrome c propagates and precedes Bax redistribution during apoptosis

31 March 2020

1 reference

Dynamics of outer mitochondrial membrane permeabilization during apoptosis.

31 March 2020

1 reference

Spatial and temporal dynamics of mitochondrial membrane permeability waves during apoptosis

31 March 2020

1 reference

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

31 March 2020

1 reference

Real-time single cell analysis of Smac/DIABLO release during apoptosis

31 March 2020

1 reference

Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration

31 March 2020

1 reference

Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis

31 March 2020

1 reference

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

31 March 2020

1 reference

Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis.

31 March 2020

1 reference

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

31 March 2020

1 reference

Structure of Bax: coregulation of dimer formation and intracellular localization

31 March 2020

1 reference

Inhibition of Bax channel-forming activity by Bcl-2

31 March 2020

1 reference

Assembly of the mitochondrial apoptosis-induced channel, MAC.

31 March 2020

1 reference

MAC inhibitors suppress mitochondrial apoptosis

31 March 2020

1 reference

Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

31 March 2020

1 reference

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

31 March 2020

1 reference

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

31 March 2020

1 reference

Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

31 March 2020

1 reference

VDAC2 inhibits BAK activation and mitochondrial apoptosis

31 March 2020

1 reference

VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria

31 March 2020

1 reference

Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations

31 March 2020

1 reference

Bax-type apoptotic proteins porate pure lipid bilayers through a mechanism sensitive to intrinsic monolayer curvature.

31 March 2020

1 reference

Bax, along with lipid conspirators, allows cytochrome c to escape mitochondria

31 March 2020

1 reference

Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation

31 March 2020

1 reference

Structural basis of pore formation by the bacterial toxin pneumolysin

31 March 2020

1 reference

Calpain I induces cleavage and release of apoptosis-inducing factor from isolated mitochondria

31 March 2020

1 reference

Cytochrome c release from mitochondria proceeds by a two-step process

31 March 2020

1 reference

Mitochondrial Release of Pro-apoptotic Proteins

31 March 2020

1 reference

Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization

31 March 2020

1 reference

A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis

31 March 2020

1 reference

Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis.

31 March 2020

1 reference

The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms

31 March 2020

1 reference

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

31 March 2020

1 reference

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

31 March 2020

1 reference

31 March 2020

1 reference

Evaluating cytochrome c diffusion in the intermembrane spaces of mitochondria during cytochrome c release

31 March 2020

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Apoptosis induced by microinjection of cytochrome c is caspase-dependent and is inhibited by Bcl-2.

31 March 2020

1 reference

Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c rel

31 March 2020

1 reference

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

31 March 2020

1 reference

Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1.

31 March 2020

1 reference

Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome

31 March 2020

1 reference

tRNA binds to cytochrome c and inhibits caspase activation

31 March 2020

1 reference

Mitochondrial regulation of caspase activation by cytochrome oxidase and tetramethylphenylenediamine via cytosolic cytochrome c redox state

31 March 2020

1 reference

Analysis of redox regulation of cytochrome c-induced apoptosis in a cell-free system

31 March 2020

1 reference

Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system.

31 March 2020

1 reference

Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts

31 March 2020

1 reference

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

31 March 2020

1 reference

Nitrosylation of cytochrome c during apoptosis

31 March 2020

1 reference

Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells

31 March 2020

1 reference

Physiological concentrations of K inhibit cytochrome c-dependent formation of the apoptosome

31 March 2020

1 reference

Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1

31 March 2020

1 reference

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

31 March 2020

1 reference

Negative regulation of the Apaf-1 apoptosome by Hsp70

31 March 2020

1 reference

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

31 March 2020

1 reference

The apoptosome: physiological, developmental, and pathological modes of regulation

31 March 2020

1 reference

Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway

31 March 2020

1 reference

PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1

31 March 2020

1 reference

pp32/PHAPI determines the apoptosis response of non-small-cell lung cancer

31 March 2020

1 reference

Nonapoptotic role for Apaf-1 in the DNA damage checkpoint

31 March 2020

1 reference

Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation.

31 March 2020

1 reference

Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis

31 March 2020

1 reference

Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.

31 March 2020

1 reference

The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer

31 March 2020

1 reference

Genome-wide silencing in Drosophila captures conserved apoptotic effectors

31 March 2020

1 reference

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

31 March 2020

1 reference

Differential requirement for caspase 9 in apoptotic pathways in vivo.

31 March 2020

1 reference

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

31 March 2020

1 reference

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

31 March 2020

1 reference

Caspase-independent cell death: leaving the set without the final cut.

31 March 2020

1 reference

Caspase-independent mitochondrial cell death results from loss of respiration, not cytotoxic protein release.

31 March 2020

1 reference

The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis

31 March 2020

1 reference

Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release

31 March 2020

1 reference

Release of OPA1 during apoptosis participates in the rapid and complete release of cytochrome c and subsequent mitochondrial fragmentation

31 March 2020

1 reference

Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics

31 March 2020

1 reference

Role of Bax and Bak in mitochondrial morphogenesis

31 March 2020

1 reference

Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization

31 March 2020

1 reference

31 March 2020

1 reference

A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c.

31 March 2020

1 reference

Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process

31 March 2020

1 reference

Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain

31 March 2020

1 reference

Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein

31 March 2020

1 reference

Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis

31 March 2020

1 reference

GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation

31 March 2020

1 reference

Apoptosome-deficient cells lose cytochrome c through proteasomal degradation but survive by autophagy-dependent glycolysis

31 March 2020

1 reference

Intra-mitochondrial degradation of Tim23 curtails the survival of cells rescued from apoptosis by caspase inhibitors

31 March 2020

1 reference

Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes

31 March 2020

1 reference

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

31 March 2020

1 reference

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

31 March 2020

1 reference

Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis

31 March 2020

1 reference

Laser micro-irradiation of mitochondria: is there an amplified mitochondrial death signal in neural cells?

31 March 2020

1 reference

Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome c

31 March 2020

1 reference

The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event

31 March 2020

1 reference

Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP.

31 March 2020

1 reference

Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis

31 March 2020

1 reference

Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis

31 March 2020

1 reference

Lack of Apaf-1 expression confers resistance to cytochrome c-driven apoptosis in cardiomyocytes

31 March 2020

1 reference

Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c.

31 March 2020

1 reference

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

31 March 2020

1 reference

Dissecting p53 tumor suppressor functions in vivo

31 March 2020

1 reference

Modulation of caspase-independent cell death leads to resensitization of imatinib mesylate-resistant cells

31 March 2020

1 reference

Resistance to caspase-independent cell death requires persistence of intact mitochondria

31 March 2020

1 reference

Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization.

31 March 2020

1 reference

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

31 March 2020

1 reference

A non-apoptotic role for caspase-9 in muscle differentiation

31 March 2020

1 reference

A unified model for apical caspase activation

31 March 2020

1 reference

Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation

31 March 2020

1 reference

Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival

31 March 2020

1 reference

The apoptosome activates caspase-9 by dimerization

31 March 2020

1 reference

Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis

31 March 2020

1 reference

Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis

31 March 2020

1 reference

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

31 March 2020

1 reference

Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

31 March 2020

1 reference

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

31 March 2020

1 reference

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

31 March 2020

1 reference

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

31 March 2020

1 reference

Generation and characterization of Smac/DIABLO-deficient mice.

31 March 2020

1 reference

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

31 March 2020

1 reference

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

31 March 2020

1 reference

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

31 March 2020

1 reference

Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization

31 March 2020

1 reference

Endonuclease G is an apoptotic DNase when released from mitochondria

31 March 2020

1 reference

Generation and characterization of endonuclease G null mice

31 March 2020

1 reference

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

31 March 2020

1 reference

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

31 March 2020

1 reference

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

31 March 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/20683470

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cytochrome c as an electron shuttle between the outer and inner mitochondrial membranes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20683470

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A cytochrome c mutant with high electron transfer and antioxidant activities but devoid of apoptogenic effect

1 reference

https://pubmed.ncbi.nlm.nih.gov/20683470

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

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9 February 2020

1024676809

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30 April 2017

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