The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling (Q29615457)

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29 December 2019

review article

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title

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling (English)

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1

O'Neill LA

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Bowie AG

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language of work or name

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publication date

1 May 2007

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Nature Reviews Immunology

29 December 2019

published in

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volume

7

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5

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page(s)

353-364

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Pathogen recognition and innate immunity

29 December 2019

cites work

1 reference

The Toll-IL-1 receptor adaptor family grows to five members.

31 March 2020

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The genome of the sea urchin Strongylocentrotus purpuratus

31 March 2020

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Genomic insights into the immune system of the sea urchin

31 March 2020

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The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling

31 March 2020

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Targeting signal transduction as a strategy to treat inflammatory diseases.

31 March 2020

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The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors

31 March 2020

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The functional effects of physical interactions among Toll-like receptors 7, 8, and 9.

31 March 2020

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The dsRNA binding site of human Toll-like receptor 3.

31 March 2020

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Interspecific comparisons reveal conserved features of the Drosophila Toll protein.

31 March 2020

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Macrophage differentiation marker MyD88 is a member of the Toll/IL-1 receptor family

31 March 2020

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MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

31 March 2020

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IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

31 March 2020

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MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

31 March 2020

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The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)

31 March 2020

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Unresponsiveness of MyD88-deficient mice to endotoxin

31 March 2020

1 reference

Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades

31 March 2020

1 reference

Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection

31 March 2020

1 reference

Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism

31 March 2020

1 reference

Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells.

31 March 2020

1 reference

MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity

31 March 2020

1 reference

Cellular Activation, Phagocytosis, and Bactericidal Activity Against Group B Streptococcus Involve Parallel Myeloid Differentiation Factor 88-Dependent and Independent Signaling Pathways

31 March 2020

1 reference

Genetically Resistant Mice Lacking MyD88-Adapter Protein Display a High Susceptibility to Leishmania major Infection Associated with a Polarized Th2 Response

31 March 2020

1 reference

Absence of innate MyD88 signaling promotes inducible allograft acceptance

31 March 2020

1 reference

MyD88-dependent induction of allergic Th2 responses to intranasal antigen.

31 March 2020

1 reference

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

31 March 2020

1 reference

Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

31 March 2020

1 reference

MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expression

31 March 2020

1 reference

IRAK-M is a negative regulator of Toll-like receptor signaling

31 March 2020

1 reference

Ubiquitin signalling in the NF-kappaB pathway

31 March 2020

1 reference

CD14 is required for MyD88-independent LPS signaling.

31 March 2020

1 reference

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

31 March 2020

1 reference

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

31 March 2020

1 reference

Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction

31 March 2020

1 reference

Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and -independent pathways

31 March 2020

1 reference

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

31 March 2020

1 reference

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

31 March 2020

1 reference

Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program

31 March 2020

1 reference

MyD88-mediated stabilization of interferon-gamma-induced cytokine and chemokine mRNA

31 March 2020

1 reference

Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammation

31 March 2020

1 reference

ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance

31 March 2020

1 reference

Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling.

31 March 2020

1 reference

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

31 March 2020

1 reference

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

31 March 2020

1 reference

Achieving stability of lipopolysaccharide-induced NF-kappaB activation

31 March 2020

1 reference

Stimulus specificity of gene expression programs determined by temporal control of IKK activity

31 March 2020

1 reference

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

31 March 2020

1 reference

Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

31 March 2020

1 reference

Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling

31 March 2020

1 reference

Differential involvement of BB loops of toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4- versus TLR2-mediated signal transduction.

31 March 2020

1 reference

A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses

31 March 2020

1 reference

Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis

31 March 2020

1 reference

TIRAP: an adapter molecule in the Toll signaling pathway

31 March 2020

1 reference

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

31 March 2020

1 reference

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

31 March 2020

1 reference

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

31 March 2020

1 reference

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

31 March 2020

1 reference

Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli

31 March 2020

1 reference

Toll/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa

31 March 2020

1 reference

Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways.

31 March 2020

1 reference

Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury

31 March 2020

1 reference

Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4.

31 March 2020

1 reference

Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.

31 March 2020

1 reference

Bruton's tyrosine kinase together with PI 3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses in macrophages

31 March 2020

1 reference

MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction

31 March 2020

1 reference

Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide

31 March 2020

1 reference

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

31 March 2020

1 reference

SOCS-1 participates in negative regulation of LPS responses

31 March 2020

1 reference

SOCS1/JAB is a negative regulator of LPS-induced macrophage activation

31 March 2020

1 reference

Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia

31 March 2020

1 reference

NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.

31 March 2020

1 reference

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

31 March 2020

1 reference

A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis

31 March 2020

1 reference

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

31 March 2020

1 reference

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

31 March 2020

1 reference

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

31 March 2020

1 reference

Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β

31 March 2020

1 reference

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

31 March 2020

1 reference

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

31 March 2020

1 reference

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

31 March 2020

1 reference

Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways

31 March 2020

1 reference

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...

31 March 2020

1 reference

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

31 March 2020

1 reference

Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation

31 March 2020

1 reference

Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta

31 March 2020

1 reference

Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling

31 March 2020

1 reference

RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

31 March 2020

1 reference

Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation

31 March 2020

1 reference

Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa.

31 March 2020

1 reference

Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif

31 March 2020

1 reference

Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways

31 March 2020

1 reference

Signaling of apoptosis through TLRs critically involves toll/IL-1 receptor domain-containing adapter inducing IFN-beta, but not MyD88, in bacteria-infected murine macrophages

31 March 2020

1 reference

TLR4 and Toll-IL-1 receptor domain-containing adapter-inducing IFN-beta, but not MyD88, regulate Escherichia coli-induced dendritic cell maturation and apoptosis in vivo

31 March 2020

1 reference

TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation

31 March 2020

1 reference

TNF receptor-associated factor-1 (TRAF1) negatively regulates Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling

31 March 2020

1 reference

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

31 March 2020

1 reference

SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways

31 March 2020

1 reference

Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.

31 March 2020

1 reference

Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4.

31 March 2020

1 reference

SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production

31 March 2020

1 reference

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence

31 March 2020

1 reference

The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense

31 March 2020

1 reference

Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

31 March 2020

1 reference

Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

31 March 2020

1 reference

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

31 March 2020

1 reference

TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.

31 March 2020

1 reference

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

31 March 2020

1 reference

31 March 2020

1 reference

Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection

31 March 2020

1 reference

A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans

31 March 2020

1 reference

SAM domains: uniform structure, diversity of function

31 March 2020

1 reference

TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM.

31 March 2020

1 reference

Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response

31 March 2020

1 reference

A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling.

31 March 2020

1 reference

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