Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K/AKT/mTOR signaling pathway (Q29568312)

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English	Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K/AKT/mTOR signaling pathway	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

25 April 2017

Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K/AKT/mTOR signaling pathway (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 April 2017

1 reference

based on heuristic

inferred from title

left ventricular hypertrophy

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based on heuristic

inferred from title

author name string

Zhichao Ma

1

1 reference

Europe PubMed Central

PubMed publication ID

25 April 2017

Jie Qi

2

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Europe PubMed Central

PubMed publication ID

25 April 2017

Shuai Meng

3

1 reference

Europe PubMed Central

PubMed publication ID

25 April 2017

Baoju Wen

4

1 reference

Europe PubMed Central

PubMed publication ID

25 April 2017

Jun Zhang

5

1 reference

Europe PubMed Central

PubMed publication ID

25 April 2017

publication date

28 June 2013

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Europe PubMed Central

PubMed publication ID

25 April 2017

European Journal of Applied Physiology

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Europe PubMed Central

PubMed publication ID

25 April 2017

113

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Europe PubMed Central

PubMed publication ID

25 April 2017

10

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Europe PubMed Central

PubMed publication ID

25 April 2017

2473-2486

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Europe PubMed Central

PubMed publication ID

25 April 2017

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Effects of fasting and refeeding on expression of atrogin-1 and Akt/FOXO signaling pathway in skeletal muscle of chicks

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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MicroRNAs in vertebrate development

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Differences between pathological and physiological cardiac hypertrophy: novel therapeutic strategies to treat heart failure

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Rapamycin attenuates load-induced cardiac hypertrophy in mice

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA.

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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C/EBPβ Controls Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

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Toward microRNA-based therapeutics for heart disease: the sense in antisense

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Phosphoinositide-3 Kinase Signaling in Cardiac Hypertrophy and Heart Failure

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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MicroRNAs 29 are involved in the improvement of ventricular compliance promoted by aerobic exercise training in rats

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

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MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy?

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Organization and regulation of mitogen-activated protein kinase signaling pathways

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Focal adhesion kinase — The basis of local hypertrophic signaling domains

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aerobic exercise training-induced left ventricular hypertrophy involves regulatory MicroRNAs, decreased angiotensin-converting enzyme-angiotensin ii, and synergistic regulation of angiotensin-converting enzyme 2-angiotensin (1-7).

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Two new miR-16 targets: caprin-1 and HMGA1, proteins implicated in cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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"Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

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Replacement treatment with microRNA-143 and -145 induces synergistic inhibition of the growth of human bladder cancer cells by regulating PI3K/Akt and MAPK signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

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Swimming training in rats increases cardiac MicroRNA-126 expression and angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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PTEN function: how normal cells control it and tumour cells lose it

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

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mTOR: from growth signal integration to cancer, diabetes and ageing

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

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MicroRNA in prostate, bladder, and kidney cancer: a systematic review.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

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The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

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Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Expanding mTOR signaling

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Physiological functions of Pten in mouse tissues

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Comprehensive expression profiling of microRNAs in laryngeal squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

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Phosphatidic acid-mediated mitogenic activation of mTOR signaling

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Muscle-specific Pten deletion protects against insulin resistance and diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TOR signaling in growth and metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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inferred from PubMed ID database lookup

Regulation of cardiac hypertrophy by intracellular signalling pathways

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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inferred from PubMed ID database lookup

Defining the role of mTOR in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Negative regulation of miR-145 by C/EBP-β through the Akt pathway in cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt1 is required for physiological cardiac growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

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The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphoinositide 3-kinases: A conserved family of signal transducers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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The roles of microRNA in cancer and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Swimming training increases cardiac vagal activity and induces cardiac hypertrophy in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

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Patterns of microRNA expression characterize stages of human B-cell differentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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TOR, a central controller of cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The fuzzy logic of physiological cardiac hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Plexin-B1 is a target of miR-214 in cervical cancer and promotes the growth and invasion of HeLa cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Akt in cardiac growth and metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphoinositide 3-kinase pathway

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https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

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Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Shp2 negatively regulates growth in cardiomyocytes by controlling focal adhesion kinase/Src and mTOR pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attenuation of MicroRNA‐22 derepressed PTEN to effectively protect rat cardiomyocytes from hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MiRNA-21 reverses high glucose and high insulin induced insulin resistance in 3T3-L1 adipocytes through targeting phosphatase and tensin homologue

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt/protein kinase B promotes organ growth in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local renin-angiotensin system regulates left ventricular hypertrophy induced by swimming training independent of circulating renin: a pharmacological study

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23812090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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