The therapeutic potential of carbon monoxide (Q29036279)

27 March 2017

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Roberto Motterlini

1

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Leo E Otterbein

series ordinal

2

object named as

Leo E. Otterbein

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27 March 2017

publication date

September 2010

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Nature Reviews Drug Discovery

27 March 2017

published in

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27 March 2017

volume

9

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27 March 2017

issue

9

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27 March 2017

page(s)

728-743

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Carbon Monoxide as a Tissue Poison

27 March 2017

cites work

1 reference

The laws of combination of haemoglobin with carbon monoxide and oxygen

31 March 2020

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The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase

31 March 2020

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Circadian rhythms. Carbon monoxide and clocks

31 March 2020

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Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus

31 March 2020

1 reference

Synergetic antioxidant and vasodilatory action of carbon monoxide in angiotensin II - induced cardiac hypertrophy

31 March 2020

1 reference

Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency

31 March 2020

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Reduced stress defense in heme oxygenase 1-deficient cells.

31 March 2020

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Inhaled NO as a therapeutic agent

31 March 2020

1 reference

Hydrogen sulphide and its therapeutic potential

31 March 2020

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CO-metal interaction: Vital signaling from a lethal gas

31 March 2020

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Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1.

31 March 2020

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Carbon monoxide reverses established pulmonary hypertension

31 March 2020

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Heme oxygenase and carbon monoxide initiate homeostatic signaling

31 March 2020

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Use of carbon monoxide as a therapeutic agent: promises and challenges

31 March 2020

1 reference

Bench-to-bedside review: Carbon monoxide--from mitochondrial poisoning to therapeutic use.

31 March 2020

1 reference

The heme oxygenase system: a regulator of second messenger gases

31 March 2020

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Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications

31 March 2020

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Regulation of heme oxygenase-1 by redox signals involving nitric oxide

31 March 2020

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Heme oxygenase-1: unleashing the protective properties of heme

31 March 2020

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Bilirubin and biliverdin treatment of atherosclerotic diseases.

31 March 2020

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Therapeutic applications of bilirubin and biliverdin in transplantation

31 March 2020

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Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema

31 March 2020

1 reference

HMOX1 promoter polymorphism modulates the relationship between disease activity and joint damage in rheumatoid arthritis

31 March 2020

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Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes in a Chinese population

31 March 2020

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Reduced expression of heme oxygenase-1 in patients with coronary atherosclerosis

31 March 2020

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Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat

31 March 2020

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Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice

31 March 2020

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Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury

31 March 2020

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Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production.

31 March 2020

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Inhibition of cellular respiration by endogenously produced carbon monoxide

31 March 2020

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NPAS2: a gas-responsive transcription factor

31 March 2020

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Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

31 March 2020

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Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury

31 March 2020

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HO-1 and CO decrease platelet-derived growth factor-induced vascular smooth muscle cell migration via inhibition of Nox1.

31 March 2020

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Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species

31 March 2020

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Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning

31 March 2020

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Mitochondrial and cellular heme-dependent proteins as targets for the bioactive function of the heme oxygenase/carbon monoxide system

31 March 2020

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Pharmacological and clinical aspects of heme oxygenase

31 March 2020

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Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver

31 March 2020

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Nitric oxide-dependent bone marrow progenitor mobilization by carbon monoxide enhances endothelial repair after vascular injury

31 March 2020

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Cardioprotective and vasomotor effects of HO activity during acute and chronic hypoxia

31 March 2020

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Heme Oxygenase-1–Derived Carbon Monoxide Contributes to the Suppression of Acute Hypertensive Responses In Vivo

31 March 2020

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Bioactivity and pharmacological actions of carbon monoxide-releasing molecules

31 March 2020

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The chemical modification of KCa channels by carbon monoxide in vascular smooth muscle cells

31 March 2020

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Exhaled Carbon Monoxide in Asthmatic Adults with Bronchial Reactivity: A Prospective Study

31 March 2020

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Exhaled carbon monoxide levels in children with sickle cell disease

31 March 2020

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Exhaled carbon monoxide levels elevated in diabetes and correlated with glucose concentration in blood: a new test for monitoring the disease?

31 March 2020

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Determination of in vivo carbon monoxide production in laboratory animals via exhaled air

31 March 2020

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Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities.

31 March 2020

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Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule

31 March 2020

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CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule

31 March 2020

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Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule

31 March 2020

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Role of cGMP in carbon monoxide-induced cerebral vasodilation in piglets

31 March 2020

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Acute renal hemodynamic effects of dimanganese decacarbonyl and cobalt protoporphyrin

31 March 2020

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Renal vascular responses to CORM-A1 in the mouse

31 March 2020

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Interaction between endogenously produced carbon monoxide and nitric oxide in regulation of renal afferent arterioles

31 March 2020

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Carbon monoxide produced by intrasinusoidally located haem-oxygenase-1 regulates the vascular tone in cirrhotic rat liver

31 March 2020

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Carbon Monoxide-Mediated Activation of Large-Conductance Calcium-Activated Potassium Channels Contributes to Mesenteric Vasodilatation in Cirrhotic Rats

31 March 2020

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Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages

31 March 2020

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Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3.

31 March 2020

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Activation of PPAR-gamma by carbon monoxide from CORM-2 leads to the inhibition of iNOS but not COX-2 expression in LPS-stimulated macrophages

31 March 2020

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Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis.

31 March 2020

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Carbon monoxide induces heme oxygenase-1 via activation of protein kinase R-like endoplasmic reticulum kinase and inhibits endothelial cell apoptosis triggered by endoplasmic reticulum stress.

31 March 2020

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Carbon monoxide activates NF-kappaB via ROS generation and Akt pathways to protect against cell death of hepatocytes

31 March 2020

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Nitric oxide-mediated cytoprotection of hepatocytes from glucose deprivation-induced cytotoxicity: involvement of heme oxygenase-1.

31 March 2020

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Carbon monoxide modulates alpha-smooth muscle actin and small proline rich-1a expression in fibrosis

31 March 2020

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Carbon monoxide suppresses bleomycin-induced lung fibrosis

31 March 2020

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Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells

31 March 2020

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Carbon monoxide promotes Fas/CD95-induced apoptosis in Jurkat cells

31 March 2020

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Systemic expression of heme oxygenase-1 ameliorates type 1 diabetes in NOD mice

31 March 2020

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Heme oxygenase-1, carbon monoxide, and bilirubin induce tolerance in recipients toward islet allografts by modulating T regulatory cells

31 March 2020

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Carbon monoxide orchestrates a protective response through PPARgamma.

31 March 2020

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A new activating role for CO in cardiac mitochondrial biogenesis

31 March 2020

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Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria.

31 March 2020

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Heme oxygenase/carbon monoxide-biliverdin pathway down regulates neutrophil rolling, adhesion and migration in acute inflammation.

31 March 2020

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Carbon monoxide liberated from carbon monoxide-releasing molecule CORM-2 attenuates inflammation in the liver of septic mice

31 March 2020

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CORM-3-derived CO modulates polymorphonuclear leukocyte migration across the vascular endothelium by reducing levels of cell surface-bound elastase.

31 March 2020

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Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo

31 March 2020

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Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis.

31 March 2020

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Treatment with a CO-releasing molecule (CORM-3) reduces joint inflammation and erosion in murine collagen-induced arthritis

31 March 2020

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Carbon monoxide and ileus: inhaled gas to prevent retained gas?

31 March 2020

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A single intraperitoneal dose of carbon monoxide-saturated ringer's lactate solution ameliorates postoperative ileus in mice

31 March 2020

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Water-soluble CO-releasing molecules reduce the development of postoperative ileus via modulation of MAPK/HO-1 signalling and reduction of oxidative stress

31 March 2020

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A carbon monoxide-releasing molecule (CORM-3) abrogates polymorphonuclear granulocyte-induced activation of endothelial cells and mast cells

31 March 2020

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Heme oxygenase-1 inhibits the expression of adhesion molecules associated with endothelial cell activation via inhibition of NF-kappaB RelA phosphorylation at serine 276.

31 March 2020

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Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation

31 March 2020

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Inhaled carbon monoxide reduces leukocytosis in a murine model of sickle cell disease

31 March 2020

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Human sickle cell blood modulates endothelial heme oxygenase activity: effects on vascular adhesion and reactivity

31 March 2020

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Heme oxygenase-1 induction remodels adipose tissue and improves insulin sensitivity in obesity-induced diabetic rats

31 March 2020

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Chronic CO levels have [corrected] a beneficial effect on vascular relaxation in diabetes

31 March 2020

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Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice

31 March 2020

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Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway

31 March 2020

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Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice

31 March 2020

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A carbon monoxide-releasing molecule (CORM-3) exerts bactericidal activity against Pseudomonas aeruginosa and improves survival in an animal model of bacteraemia

31 March 2020

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Carbon monoxide rescues heme oxygenase-1-deficient mice from arterial thrombosis in allogeneic aortic transplantation

31 March 2020

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Carbon monoxide released by CORM-3 inhibits human platelets by a mechanism independent of soluble guanylate cyclase

31 March 2020

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Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo

31 March 2020

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Beneficial effects of carbon monoxide-releasing molecules on post-ischemic myocardial recovery

31 March 2020

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Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels

31 March 2020

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The RCK1 high-affinity Ca2 sensor confers carbon monoxide sensitivity to Slo1 BK channels

31 March 2020

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Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury

31 March 2020

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Inhaled carbon monoxide inhibits intimal hyperplasia and provides added benefit with nitric oxide

31 March 2020

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Inhaled carbon monoxide prevents graft-induced intimal hyperplasia in swine.

31 March 2020

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Safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents

31 March 2020

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Delayed re-endothelialization with rapamycin-coated stents is rescued by the addition of a glycogen synthase kinase-3beta inhibitor

31 March 2020

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Heme oxygenase-1-derived carbon monoxide protects hearts from transplant associated ischemia reperfusion injury

31 March 2020

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Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants

31 March 2020

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Carbon monoxide protects against ischemia-reperfusion injury in an experimental model of controlled nonheartbeating donor kidney

31 March 2020

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Protective effect of carbon monoxide in transplantation

31 March 2020

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Treatment with CO-RMs during cold storage improves renal function at reperfusion.

31 March 2020

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Improved myocardial function after cold storage with preservation solution supplemented with a carbon monoxide-releasing molecule (CORM-3).

31 March 2020

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Protective effects of a carbon monoxide-releasing molecule (CORM-3) during hepatic cold preservation.

31 March 2020

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Carbon Monoxide Inhalation Protects Rat Intestinal Grafts from Ischemia/Reperfusion Injury

31 March 2020

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Ex vivo application of carbon monoxide in University of Wisconsin solution to prevent intestinal cold ischemia/reperfusion injury

31 March 2020

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Protection of transplant-induced renal ischemia-reperfusion injury with carbon monoxide

31 March 2020

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Carbon monoxide (CO) protects renal tubular epithelial cells against cold-rewarm apoptosis

31 March 2020

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Ex vivo carbon monoxide prevents cytochrome P450 degradation and ischemia/reperfusion injury of kidney grafts

31 March 2020

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Ex vivo application of carbon monoxide in UW solution prevents transplant-induced renal ischemia/reperfusion injury in pigs

31 March 2020

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Therapeutic applications of carbon monoxide-releasing molecules

31 March 2020

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Therapeutic applications of the gaseous mediators carbon monoxide and hydrogen sulfide

31 March 2020

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Chemistry and biological activities of CO-releasing molecules (CORMs) and transition metal complexes

31 March 2020

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Carbon monoxide, reactive oxygen signaling, and oxidative stress

31 March 2020

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Biological chemistry of carbon monoxide

31 March 2020

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Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle

31 March 2020

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Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs

31 March 2020

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Carbon monoxide inhalation rescues mice from fulminant hepatitis through improving hepatic energy metabolism.

31 March 2020

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The effect of carbon monoxide on respiration

31 March 2020

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Interaction of carbon monoxide with the apoptosis-inducing cytochrome c-cardiolipin complex

31 March 2020

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Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1

31 March 2020

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A new road to induce heme oxygenase-1 expression by carbon monoxide

31 March 2020

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Heart allograft protection with low-dose carbon monoxide inhalation: effects on inflammatory mediators and alloreactive T-cell responses

31 March 2020

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Carbon monoxide-saturated preservation solution protects lung grafts from ischemia-reperfusion injury

31 March 2020

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Reciprocal regulation of airway rejection by the inducible gas-forming enzymes heme oxygenase and nitric oxide synthase

31 March 2020

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Carbon monoxide rescues ischemic lungs by interrupting MAPK-driven expression of early growth response 1 gene and its downstream target genes

31 March 2020

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Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury

31 March 2020

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Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis

31 March 2020

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Oxygen radical-mediated injury of myocytes-protection by propranolol

31 March 2020

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Liver graft exposure to carbon monoxide during cold storage protects sinusoidal endothelial cells and ameliorates reperfusion injury in rats

31 March 2020

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Protection of transplant-induced hepatic ischemia/reperfusion injury with carbon monoxide via MEK/ERK1/2 pathway downregulation

31 March 2020

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Low-dose carbon monoxide inhalation prevents development of chronic allograft nephropathy

31 March 2020

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Low-dose carbon monoxide inhibits progressive chronic allograft nephropathy and restores renal allograft function.

31 March 2020

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Inhalation of carbon monoxide prevents liver injury and inflammation following hind limb ischemia/reperfusion

31 March 2020

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Ex vivo exposure to carbon monoxide prevents hepatic ischemia/reperfusion injury through p38 MAP kinase pathway.

31 March 2020

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Immunomodulatory effects of inhaled carbon monoxide on rat syngeneic small bowel graft motility

31 March 2020

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Protective effect of carbon monoxide inhalation for cold-preserved small intestinal grafts

31 March 2020

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Donor Treatment With Carbon Monoxide Can Yield Islet Allograft Survival and Tolerance

31 March 2020

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High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice

31 March 2020

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Carbon monoxide pretreatment prevents respiratory derangement and ameliorates hyperacute endotoxic shock in pigs.

31 March 2020

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Hemorrhagic shock resuscitation with carbon monoxide saturated blood

31 March 2020

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Carbon Monoxide-Releasing Molecules Modulate Leukocyte-Endothelial Interactions under Flow

31 March 2020

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MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury

31 March 2020

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Inhaled carbon monoxide suppresses the development of postoperative ileus in the murine small intestine.

31 March 2020

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Brief inhalation of low-dose carbon monoxide protects rodents and swine from postoperative ileus.

31 March 2020

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Protective effects of low-dose carbon monoxide against renal fibrosis induced by unilateral ureteral obstruction.

31 March 2020

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Continuous inhalation of carbon monoxide attenuates hypoxic pulmonary hypertension development presumably through activation of BKCa channels

31 March 2020

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Carbon monoxide protects against cardiac ischemia--reperfusion injury in vivo via MAPK and Akt--eNOS pathways

31 March 2020

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Protection against cisplatin-induced nephrotoxicity by a carbon monoxide-releasing molecule

31 March 2020

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Heme oxygenase metabolites inhibit tubuloglomerular feedback (TGF)

31 March 2020

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A water-soluble carbon monoxide-releasing molecule (CORM-3) lowers intraocular pressure in rabbits.

31 March 2020

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Cerebroprotective effects of the CO-releasing molecule CORM-A1 against seizure-induced neonatal vascular injury

31 March 2020

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Carbon monoxide signalling reduces photocarcinogenesis in the hairless mouse.

31 March 2020

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Role of CO-releasing molecules liberated CO in attenuating leukocytes sequestration and inflammatory responses in the lung of thermally injured mice

31 March 2020

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Carbon monoxide protects against the development of experimental necrotizing enterocolitis

31 March 2020

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Low-dose carbon monoxide reduces airway hyperresponsiveness in mice

31 March 2020

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Carbon liberated from CO-releasing molecules attenuates leukocyte infiltration in the small intestine of thermally injured mice.

31 March 2020

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Carbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs

31 March 2020

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Antimicrobial action of carbon monoxide-releasing compounds

31 March 2020

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Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase

31 March 2020

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12 December 2020

CO liberated from CORM-2 modulates the inflammatory response in the liver of thermally injured mice

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12 December 2020

The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy

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12 December 2020

Antioxidant activities of bile pigments

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12 December 2020

Endothelium-Dependent and -Independent Vasodilation Involving Cyclic GMP: Relaxation Induced by Nitric Oxide, Carbon Monoxide and Light

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12 December 2020

Modulation of BKCa channel gating by endogenous signaling molecules

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12 December 2020

Carbon monoxide provides protection against hyperoxic lung injury

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12 December 2020

Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation.

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12 December 2020

Early recognition of a discordant xenogeneic organ by human circulating lymphocytes.

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12 December 2020

Biological analysis and dosimetry for 15O-labeled O2, CO2, and CO gases administered continuously by inhalation.

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12 December 2020

Identifiers

DOI

10.1038/NRD3228

2 references

27 March 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1012649020

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

20811383

1 reference

Consolidated OpenCitations Corpus – April 2017