Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition (Q29028790)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26272049 AND SRC:MED&resulttype=core&format=json

22 February 2020

title

Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition (English)

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22 February 2020

1

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22 February 2020

John Georgiou

4

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22 February 2020

Enoch Ng

6

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22 February 2020

Christina L. Elliott

8

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22 February 2020

Jonathan Mullins

10

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22 February 2020

George Baillie

12

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22 February 2020

13

Steven J Clapcote

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22 February 2020

author name string

Tatiana V Lipina

2

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22 February 2020

Ho-Suk Mun

3

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22 February 2020

Ahmed H Al-Amri

5

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22 February 2020

Dongxu Zhai

7

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22 February 2020

Ryan T Cameron

9

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22 February 2020

Fang Liu

11

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22 February 2020

John C Roder

14

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22 February 2020

language of work or name

English

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publication date

14 August 2015

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full work available at URL

22 February 2020

http://eprints.whiterose.ac.uk/89082/

content deliverer

White Rose Research Online

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published in

Neuropsychopharmacology

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22 February 2020

volume

41

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22 February 2020

issue

4

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22 February 2020

page(s)

1080-1092

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PDE4 as a target for cognition enhancement

22 February 2020

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Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect

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Regulation of amygdalar PKA by beta-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning

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3 June 2018

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3 June 2018

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3 June 2018

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Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain

3 June 2018

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Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases

3 June 2018

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Phosphodiesterase 4B (PDE4B) and cAMP-level regulation within different tissue fractions of rat hippocampal slices during long-term potentiation in vitro.

3 June 2018

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PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6).

21 January 2018

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Rolipram attenuates MK-801-induced deficits in latent inhibition

21 January 2018

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Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats.

21 January 2018

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Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues

21 January 2018

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Disc1 point mutations in mice affect development of the cerebral cortex

21 January 2018

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Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats

21 January 2018

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Up-regulation of exploratory tendencies does not enhance general learning abilities in juvenile or young-adult outbred mice

21 January 2018

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Exploration in outbred mice covaries with general learning abilities irrespective of stress reactivity, emotionality, and physical attributes

21 January 2018

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Discovery of selective PDE4B inhibitors

21 January 2018

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Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population

21 January 2018

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The PDE4B gene confers sex-specific protection against schizophrenia

21 January 2018

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DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan

21 January 2018

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Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia

21 January 2018

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Differential distribution of PDE4B splice variant mRNAs in rat brain and the effects of systemic administration of LPS in their expression

21 January 2018

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Enhanced long-term depression and impaired reversal learning in phosphodiesterase 4B-knockout (PDE4B-/-) mice

21 January 2018

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GSK356278, a potent, selective, brain-penetrant phosphodiesterase 4 inhibitor that demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in preclinical species

21 January 2018

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Effects of rolipram on the elevated plus-maze test in rats: a preliminary study

21 January 2018

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Antipsychotic profile of rolipram: efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4B (PDE4B) enzyme

21 January 2018

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Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-4B (PDE4B) enzyme.

21 January 2018

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Attenuating the persistence of fear memory storage using a single dose of antidepressant

21 January 2018

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Association study of PDE4B gene variants in Scandinavian schizophrenia and bipolar disorder multicenter case-control samples

21 January 2018

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Administration of a cAMP phosphodiesterase 4 inhibitor enhances antidepressant-induction of BDNF mRNA in rat hippocampus

26 November 2018

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Association of PDE4B polymorphisms and schizophrenia in Northwestern Han Chinese

31 March 2020

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Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NPP.2015.240

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26272049 AND SRC:MED&resulttype=core&format=json

22 February 2020

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Dimensions Publication ID

1023331073

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Fatcat ID

release_5cwei7hiobh6dfcz65z56f3kp4

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/5cwei7hiobh6dfcz65z56f3kp4

mapped directly with Wikidata item

24 November 2022

based on heuristic

OpenCitations bibliographic resource ID

427646

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26272049 AND SRC:MED&resulttype=core&format=json

22 February 2020

PubMed publication ID

26272049

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26272049 AND SRC:MED&resulttype=core&format=json