Solution structure and binding specificity of the p63 DNA binding domain (Q28833410)

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2 April 2020

title

Solution structure and binding specificity of the p63 DNA binding domain (English)

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2 April 2020

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5

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2 April 2020

Franz Hagn

7

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2 April 2020

author name string

Andreas Enthart

1

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2 April 2020

Christian Klein

2

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2 April 2020

Alexander Dehner

3

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2 April 2020

Murray Coles

4

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2 April 2020

Horst Kessler

6

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2 April 2020

language of work or name

English

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publication date

26 May 2016

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2 April 2020

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2 April 2020

volume

6

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2 April 2020

page(s)

26707

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Creative Commons Attribution 4.0 International

2 April 2020

copyright license

start time

1 May 2016

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Pliable DNA Conformation of Response Elements Bound to Transcription Factor p63

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Structures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elements

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

The first 30 years of p53: growing ever more complex

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

p63 protects the female germ line during meiotic arrest

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

The role of p63 in development and differentiation of the epidermis

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

p53 has a direct apoptogenic role at the mitochondria

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

The p53 family member genes are involved in the Notch signal pathway

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

The solution structure of the N-terminal domain of riboflavin synthase

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Structure of the C-terminal sterile alpha-motif (SAM) domain of human p73 alpha

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain.

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

p63 is a p53 homologue required for limb and epidermal morphogenesis

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Protein backbone angle restraints from searching a database for chemical shift and sequence homology

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Thermodynamic stability of wild-type and mutant p53 core domain

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Cancer. p53, guardian of the genome

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

TAp63 and DeltaNp63 in cancer and epidermal development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Common evolutionary origin of swapped-hairpin and double-psi beta barrels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

p53--a natural cancer killer: structural insights and therapeutic concepts

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Structure of the p53 core domain dimer bound to DNA.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Solution structure of p53 core domain: structural basis for its instability

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

p63 and epithelial biology

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Defining the p53 DNA-binding domain/Bcl-x(L)-binding interface using NMR.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Differential expression of p63 isoforms in normal tissues and neoplastic cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

On the shoulders of giants: p63, p73 and the rise of p53.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

From p63 to p53 across p73.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Down-regulation of p63 is required for epidermal UV-B-induced apoptosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Split-hand/split-foot malformation is caused by mutations in the p63 gene on 3q27.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

The p53/p63/p73 family of transcription factors: overlapping and distinct functions.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Mutational analysis of the p63/p73L/p51/p40/CUSP/KET gene in human cancer cell lines using intronic primers

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

The transcriptional activities of p53 and its homologue p51/p63: similarities and differences.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

H(C)CH-COSY and (H)CCH-COSY experiments for 13C-labeled proteins in H2O solution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Structural aspects of the p53 protein in relation to gene evolution: a second look.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

New insights into p53 function from structural studies

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

Stability of proteins: small globular proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880913

TP63 gene mutation in ADULT syndrome

20 June 2018

1 reference

High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.

21 January 2018

1 reference

Adaptive evolution of p53 thermodynamic stability

21 January 2018

1 reference

p63 consensus DNA-binding site: identification, analysis and application into a p63MH algorithm

21 January 2018

1 reference

Life or death: p53-induced apoptosis requires DNA binding cooperativity.

21 January 2018

1 reference

DNA binding cooperativity of p53 modulates the decision between cell-cycle arrest and apoptosis.

21 January 2018

1 reference

Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL.

21 January 2018

1 reference

An efficient strategy for assignment of cross-peaks in 3D heteronuclear NOESY experiments

21 January 2018

1 reference

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

21 January 2018

2 references

21 January 2018

12 December 2020

Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63

1 reference

12 December 2020

Cooperative binding of p53 to DNA: regulation by protein-protein interactions through a double salt bridge

1 reference

12 December 2020

EEC syndrome type 3 with a heterozygous germline mutation in the P63 gene and B cell lymphoma

1 reference

12 December 2020

Backbone 1H, 13C and 15N resonance assignments for the 25.8 kDa DNA binding domain of the human p63 protein

1 reference

12 December 2020

Pharmacological rescue of mutant p53 conformation and function

1 reference

12 December 2020

Identifiers

DOI

10.1038/SREP26707

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27225672 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

2 April 2020

1007974526

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27225672 AND SRC:MED&resulttype=core&format=json

2 April 2020

PubMed publication ID

27225672

2 references