The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals (Q28830903)

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15 March 2020

title

The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals (English)

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15 March 2020

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8

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15 March 2020

author name string

Tongchao Li

1

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15 March 2020

Nikolaos Giagtzoglou

2

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15 March 2020

Daniel F Eberl

3

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15 March 2020

Sonal Nagarkar Jaiswal

4

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Tiantian Cai

5

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Dorothea Godt

6

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Andrew K Groves

7

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language of work or name

English

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publication date

22 June 2016

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15 March 2020

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15 March 2020

volume

5

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A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases

15 March 2020

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Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction

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Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2

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Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle

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Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9

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The autosomal recessive isolated deafness, DFNB2, and the Usher 1B syndrome are allelic defects of the myosin-VIIA gene

16 March 2017

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16 March 2017

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Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination

7 April 2017

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Pri sORF peptides induce selective proteasome-mediated protein processing

3 June 2018

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3 June 2018

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Cardiac Nav 1.5 is modulated by ubiquitin protein ligase E3 component n-recognin UBR3 and 6.

3 June 2018

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3 June 2018

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Hearing in Drosophila

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3 June 2018

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Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila

3 June 2018

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R705H mutation of MYH9 is associated with MYH9-related disease and not only with non-syndromic deafness DFNA17.

3 June 2018

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The Drosophila auditory system

3 June 2018

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3 June 2018

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Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability

3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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Linking genes underlying deafness to hair-bundle development and function

3 June 2018

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The neural basis of Drosophila gravity-sensing and hearing

3 June 2018

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Characterization of the Drosophila ortholog of the human Usher Syndrome type 1G protein sans

3 June 2018

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Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development

3 June 2018

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3 June 2018

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Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells

3 June 2018

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3 June 2018

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3 June 2018

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Drosophila melanogaster Cad99C, the orthologue of human Usher cadherin PCDH15, regulates the length of microvilli

3 June 2018

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Myosin VIIA defects, which underlie the Usher 1B syndrome in humans, lead to deafness in Drosophila

3 June 2018

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Cadherin Cad99C is regulated by Hedgehog signaling in Drosophila.

3 June 2018

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3 June 2018

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3 June 2018

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Drosophila Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase

3 June 2018

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atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system

3 June 2018

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3 June 2018

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Cytoplasmic myosin from Drosophila melanogaster

3 June 2018

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Characterization and spatial distribution of the ELAV protein duringDrosophila melanogaster development

3 June 2018

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gcm2 promotes glial cell differentiation and is required with glial cells missing for macrophage development in Drosophila

3 June 2018

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nompA encodes a PNS-specific, ZP domain protein required to connect mechanosensory dendrites to sensory structures

21 January 2018

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Recording sound-evoked potentials from the Drosophila antennal nerve.

21 January 2018

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An MYH9 human disease model in flies: site-directed mutagenesis of the Drosophila non-muscle myosin II results in hypomorphic alleles with dominant character.

21 January 2018

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Myosin VIIA regulates microvillus morphogenesis and interacts with cadherin Cad99C in Drosophila oogenesis

21 January 2018

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Biomechanics. Turning the key on Drosophila audition

21 January 2018

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Comprehensive classification of the auditory sensory projections in the brain of the fruit fly Drosophila melanogaster

21 January 2018

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The collagen receptor DDR1 co-localizes with the non-muscle myosin IIA in mice inner ear and contributes to the cytoarchitecture and stability of motile cells.

21 January 2018

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Expression of Myh9 in the mammalian cochlea: localization within the stereocilia

21 January 2018

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Drosophila skpA, a component of SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation

21 January 2018

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Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit.

21 January 2018

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Cadherin Cad99C is required for normal microvilli morphology in Drosophila follicle cells

21 January 2018

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Drosophila auditory organ genes and genetic hearing defects

21 January 2018

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Drosophila atonal fully rescues the phenotype of Math1 null mice: new functions evolve in new cellular contexts.

21 January 2018

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Neddylation and deneddylation regulate Cul1 and Cul3 protein accumulation.

21 January 2018

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Neuronal development in the Drosophila retina: monoclonal antibodies as molecular probes.

21 January 2018

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The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila

21 January 2018

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Reconstructing the coding and non-coding RNA regulatory networks of miRNAs and mRNAs in breast cancer

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27331610

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.7554/ELIFE.15258

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27331610 AND SRC:MED&resulttype=core&format=json

release_dqaq2xoqjfb5rjum4ijsr7nrvu

15 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/dqaq2xoqjfb5rjum4ijsr7nrvu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27331610 AND SRC:MED&resulttype=core&format=json

15 March 2020

PubMed publication ID

27331610

2 references