Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells (Q28816971)

1

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Yuko Shishido

13

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4 June 2020

Elias Arnér

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Katarina Johansson

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Danyelle M Townsend

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Kenneth D Tew

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4 June 2020

author name string

Marcus Cebula

2

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4 June 2020

Jie Zhang

3

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4 June 2020

Astrid Ottosson-Wadlund

4

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4 June 2020

Ludwig Dubois

5

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4 June 2020

Philippe Lambin

6

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4 June 2020

Guido R M M Haenen

9

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4 June 2020

Marie-José Drittij-Reijnders

10

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4 June 2020

Hisao Saneyoshi

11

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4 June 2020

Mika Araki

12

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4 June 2020

Yoshihiro Ito

14

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4 June 2020

Hiroshi Abe

16

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4 June 2020

Ralf Morgenstern

17

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4 June 2020

language of work or name

English

0 references

publication date

6 June 2016

0 references

published in

Molecular Pharmaceutics

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volume

13

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issue

6

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4 June 2020

page(s)

2010-2025

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TrxR1 as a potent regulator of the Nrf2-Keap1 response system

4 June 2020

cites work

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Overcoming drug efflux-based multidrug resistance in cancer with nanotechnology

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The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c

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Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism

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A multidrug resistance transporter from human MCF-7 breast cancer cells

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Glutathione S-transferases. The first enzymatic step in mercapturic acid formation

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Cancer drug resistance: an evolving paradigm

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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

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Drug resistance and the solid tumor microenvironment

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Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling

7 April 2017

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Etoposide induces cell death via mitochondrial-dependent actions of p53.

20 June 2018

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Role of glutathione, glutathione transferase, and glutaredoxin in regulation of redox-dependent processes.

20 June 2018

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Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression

20 June 2018

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Cytoprotective and regulatory functions of glutathione S-transferases in cancer cell proliferation and cell death

20 June 2018

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Increasing the cytotoxicity of doxorubicin in breast cancer MCF-7 cells with multidrug resistance using a mesoporous silica nanoparticle drug delivery system

20 June 2018

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Etoposide resistance in MCF-7 breast cancer cell line is marked by multiple mechanisms

20 June 2018

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Nanoparticle-directed sub-cellular localization of doxorubicin and the sensitization breast cancer cells by circumventing GST-mediated drug resistance.

20 June 2018

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A novel anthracene derivative, MHY412, induces apoptosis in doxorubicin-resistant MCF-7/Adr human breast cancer cells through cell cycle arrest and downregulation of P-glycoprotein expression

20 June 2018

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Role of glutathione in cancer progression and chemoresistance

20 June 2018

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Persistent activation of DNA damage signaling in response to complex mixtures of PAHs in air particulate matter

20 June 2018

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Gene expression alterations in doxorubicin resistant MCF7 breast cancer cell line

20 June 2018

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Drug delivery systems: An updated review

20 June 2018

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Structural modifications modulate stability of glutathione-activated arylated diazeniumdiolate prodrugs

20 June 2018

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Etoposide-mediated glioblastoma cell death: dependent or independent on the expression of its target, topoisomerase II alpha?

20 June 2018

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Characterization of new potential anticancer drugs designed to overcome glutathione transferase mediated resistance

20 June 2018

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Measurement of Thioredoxin and Thioredoxin Reductase

20 June 2018

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Glutathione transferases and development of new principles to overcome drug resistance

20 June 2018

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20 June 2018

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Impaired DNA damage response--an Achilles' heel sensitizing cancer to chemotherapy and radiotherapy

20 June 2018

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Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron

20 June 2018

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Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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Antibody therapy in aggressive lymphomas

20 June 2018

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20 June 2018

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20 June 2018

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Microsomal glutathione transferase 1 in anticancer drug resistance

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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The role of glutathione-S-transferase in anti-cancer drug resistance

20 June 2018

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Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress.

20 June 2018

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Glutathione conjugation and DNA adduct formation of dibenzo[a,l]pyrene and benzo[a]pyrene diol epoxides in V79 cells stably expressing different human glutathione transferases.

20 June 2018

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Role of glutathione S-transferase P1, P-glycoprotein and multidrug resistance-associated protein 1 in acquired doxorubicin resistance

20 June 2018

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Overexpression of glutathione-S-transferase A1 in benign adrenocortical adenomas from patients with Cushing's syndrome

20 June 2018

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Resistance factors in colon cancer tissue and the adjacent normal colon tissue: glutathione S-transferases α and π, glutathione and aldehyde dehydrogenase

20 June 2018

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A Simple Alternate Substrate Test Can Help Determine the Aqueous or Bilayer Location of Binding Sites for Hydrophobic Ligands/Substrates on Membrane Proteins

20 June 2018

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Mutagenesis of structural half-cystine residues in human thioredoxin and effects on the regulation of activity by selenodiglutathione.

20 June 2018

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Glutathione-associated enzymes in anticancer drug resistance.

20 June 2018

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Studies on the activity and activation of rat liver microsomal glutathione transferase, in particular with a substrate analogue series

20 June 2018

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Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells.

20 June 2018

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The hypersensitivity of the Chinese hamster ovary variant BL-10 to bleomycin killing is due to a lack of glutathione S-transferase-alpha activity

20 June 2018

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20 June 2018

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Multidrug Resistance in Breast Cancer: FromIn VitroModels to Clinical Studies

26 November 2018

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Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase

26 November 2018

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26 November 2018

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26 November 2018

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26 November 2018

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26 November 2018

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26 November 2018

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26 November 2018

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Effect of glutathione depletion by buthionine sulfoximine on doxorubicin toxicity in mice.

26 November 2018

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Role of glutathione S-transferases in the resistance of human colon cancer cell lines to doxorubicin

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12 December 2020

Glutathione S-transferase isoenzymes and glutathione peroxidase activity in normal and tumour samples from human lung

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7-monohydroxyethylrutoside protects against chronic doxorubicin-induced cardiotoxicity when administered only once per week

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Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method

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Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung

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10.1021/ACS.MOLPHARMACEUT.6B00140

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27093577 AND SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27093577 AND SRC:MED&resulttype=core&format=json

4 June 2020

PubMed publication ID

27093577

1 reference