Extensive phosphorylation of Smoothened in Hedgehog pathway activation (Q28770067)

Casein kinase Ialpha Dmel_CG2028

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Hedgehog Dmel_CG4637

1 reference

GOA release 2020-03-11

1 reference

Elizabeth H Williams

2

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author name string

Chi Zhang

1

0 references

Yurong Guo

3

0 references

Lawrence Lum

4

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Philip A Beachy

Proceedings of the National Academy of Sciences of the United States of America

5

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language of work or name

English

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publication date

28 December 2004

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published in

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volume

101

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issue

52

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page(s)

17900-7

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cites work

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The Hedgehog response network: sensors, switches, and routers

16 March 2017

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Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2

16 March 2017

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Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2

16 March 2017

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Patched acts catalytically to suppress the activity of Smoothened

16 March 2017

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Hedgehog signaling in animal development: paradigms and principles

16 March 2017

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Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity

16 March 2017

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Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system

16 March 2017

1 reference

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Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

16 March 2017

1 reference

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Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched

16 March 2017

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Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway

16 March 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

16 March 2017

1 reference

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Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

16 March 2017

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Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations

16 March 2017

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Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae

7 April 2017

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Kinase peptide specificity: improved determination and relevance to protein phosphorylation

7 April 2017

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Drosophila Costal1 mutations are alleles of protein kinase A that modulate hedgehog signaling

3 June 2018

1 reference

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Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction

3 June 2018

1 reference

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Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.

3 June 2018

1 reference

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Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Dual pathways for induction of wingless expression by protein kinase A and Hedgehog inDrosophila embryos

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Biochemical evidence that patched is the Hedgehog receptor

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Phosphorylation of the fused protein kinase in response to signaling from hedgehog

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

The Suppressor of fused gene encodes a novel PEST protein involved in Drosophila segment polarity establishment

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Repression of ci-D in posterior compartments of Drosophila by engrailed

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Mutations in the catalytic subunit of cAMP-dependent protein kinase result in unregulated biological activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal

3 June 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0408093101

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0408093101

Genetic dissection of the Drosophila Cubitus interruptus signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0408093101

Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0408093101

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0408093101

Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0408093101

Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0408093101

Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0408093101

Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0408093101

Selective adsorption of phosphoproteins on gel-immobilized ferric chelate

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0408093101

Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Analysis of cubitus interruptus regulation in Drosophila embryos and imaginal disks

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535705

Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15598741

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Protein kinase A deficiency causes axially localized neural tube defects in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15598741

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Isolation of phosphoproteins by immobilized metal (Fe3 ) affinity chromatography

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15598741

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0408093101

1 reference

ADS bibcode

2004PNAS..10117900Z

0 references

1 reference

1 reference

PubMed publication ID

15598741

1 reference