Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG) (Q28750668)

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Jikun Li

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Ke Wang

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Cancan Huang

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Yong Zhang

Proceedings of the National Academy of Sciences of the United States of America

5

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language of work or name

English

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publication date

22 June 2010

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published in

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volume

107

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issue

25

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page(s)

11189-93

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cites work

Bioorganometallic mechanism of action, and inhibition, of IspH

1 reference

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Probing the reaction mechanism of IspH protein by x-ray structure analysis

16 March 2017

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Biosynthesis of isoprenoids via the non-mevalonate pathway

16 March 2017

1 reference

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The reduced [2Fe-2S] clusters in adrenodoxin and Arthrospira platensis ferredoxin share spin density with protein nitrogens, probed using 2D ESEEM.

16 March 2017

1 reference

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From molecular fossils of bacterial hopanoids to the formation of isoprene units: discovery and elucidation of the methylerythritol phosphate pathway

3 June 2018

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Ligand-bound S = 1/2 FeMo-cofactor of nitrogenase: hyperfine interaction analysis and implication for the central ligand X identity

3 June 2018

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Isoprenoid biosynthesis in chloroplasts via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) from Arabidopsis thaliana is a [4Fe-4S] protein

3 June 2018

1 reference

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Isoprenoid biosynthesis as a novel target for antibacterial and antiparasitic drugs.

3 June 2018

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A proposed mechanism for the reductive ring opening of the cyclodiphosphate MEcPP, a crucial transformation in the new DXP/MEP pathway to isoprenoids based on modeling studies and feeding experiments

3 June 2018

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The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: studies on the mechanisms of the reactions catalyzed by IspG and IspH protein

3 June 2018

1 reference

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Isoprenoid biosynthesis through the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) is a [4Fe-4S] protein

3 June 2018

1 reference

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Synthesis of analogues of (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate, an isoprenoid precursor and human gamma delta T cell activator

3 June 2018

1 reference

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Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis

21 January 2018

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IspG converts an epoxide substrate analogue to (E)-4-hydroxy-3-methylbut-2-enyl diphosphate: implications for IspG catalysis in isoprenoid biosynthesis.

21 January 2018

1 reference

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An organometallic intermediate during alkyne reduction by nitrogenase.

21 January 2018

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Electron delocalization in the metallabenzenes: a computational analysis of ring currents

21 January 2018

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EasySpin, a comprehensive software package for spectral simulation and analysis in EPR.

21 January 2018

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21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20534554

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Possible direct involvement of the active-site [4Fe-4S] cluster of the GcpE enzyme from Thermus thermophilus in the conversion of MEcPP

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20534554

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1000264107

1 reference

ADS bibcode

2010PNAS..10711189W

0 references

1 reference

1 reference

PubMed publication ID

20534554

1 reference