The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit (Q28749570)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20733055 AND SRC:MED&resulttype=core&format=json

11 February 2020

title

The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit (English)

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11 February 2020

4

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11 February 2020

Rob M F Wolthuis

6

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11 February 2020

author name string

Wouter van Zon

1

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11 February 2020

Janneke Ogink

2

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11 February 2020

Bas ter Riet

3

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11 February 2020

Hein te Riele

5

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11 February 2020

language of work or name

English

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publication date

1 August 2010

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11 February 2020

published in

Journal of Cell Biology

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11 February 2020

volume

190

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11 February 2020

issue

4

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11 February 2020

page(s)

587-602

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The decision to enter mitosis: feedback and redundancy in the mitotic entry network

11 February 2020

cites work

1 reference

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Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism.

16 March 2017

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The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

16 March 2017

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Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells

16 March 2017

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Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression

16 March 2017

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Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

16 March 2017

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Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint

16 March 2017

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Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C

16 March 2017

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The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates

16 March 2017

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Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation

16 March 2017

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Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

16 March 2017

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Gene expression profiling predicts clinical outcome of breast cancer

16 March 2017

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The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner

16 March 2017

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Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint

16 March 2017

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Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

16 March 2017

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The localization of human cyclins B1 and B2 determines CDK1 substrate specificity and neither enzyme requires MEK to disassemble the Golgi apparatus

16 March 2017

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The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B

16 March 2017

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The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae

16 March 2017

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Temporal and spatial control of cyclin B1 destruction in metaphase

16 March 2017

1 reference

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Cyclin A and Nek2A: APC/C-Cdc20 substrates invisible to the mitotic spindle checkpoint

7 April 2017

1 reference

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Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly.

20 June 2018

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Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex

20 June 2018

1 reference

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Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding

20 June 2018

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APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.

20 June 2018

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Cyclin-specific control of ribosomal DNA segregation

20 June 2018

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To cell cycle, swing the APC/C.

20 June 2018

1 reference

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The kinetochore and spindle checkpoint in mammals

20 June 2018

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Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.

20 June 2018

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The spindle checkpoint: how do cells delay anaphase onset?

20 June 2018

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Finishing mitosis, one step at a time.

20 June 2018

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Distinct sequence elements of cyclin B1 promote localization to chromatin, centrosomes, and kinetochores during mitosis

20 June 2018

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Cdc20: a WD40 activator for a cell cycle degradation machine

20 June 2018

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Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis

20 June 2018

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Dose-dependent effects of stable cyclin B1 on progression through mitosis in human cells

20 June 2018

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Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding

20 June 2018

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Mitosis: a matter of getting rid of the right protein at the right time

20 June 2018

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Coactivator functions in a stoichiometric complex with anaphase-promoting complex/cyclosome to mediate substrate recognition

20 June 2018

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Assembly of an APC-Cdh1-substrate complex is stimulated by engagement of a destruction box.

20 June 2018

1 reference

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Basic mechanism of eukaryotic chromosome segregation

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928021

Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928021

Securin and B-cyclin/CDK are the only essential targets of the APC.

20 June 2018

1 reference

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Germline exclusion of Cks1 in the mouse reveals a metaphase I role for Cks proteins in male and female meiosis.

20 June 2018

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Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928021

D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928021

A nonproteolytic function of the proteasome is required for the dissociation of Cdc2 and cyclin B at the end of M phase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928021

On the concentrations of cyclins and cyclin-dependent kinases in extracts of cultured human cells.

20 June 2018

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Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex

20 June 2018

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The xenopus Suc1/Cks protein promotes the phosphorylation of G(2)/M regulators

20 June 2018

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Xe-p9, a Xenopus Suc1/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase- promoting complex at mitosis

20 June 2018

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Binding of activated cyclosome to p13(suc1). Use for affinity purification

20 June 2018

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Cell cycle: reaching for a role for the Cks proteins

20 June 2018

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Xe-p9, a Xenopus Suc1/Cks homolog, has multiple essential roles in cell cycle control

20 June 2018

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Destruction of Xenopus cyclins A and B2, but not B1, requires binding to p34cdc2.

20 June 2018

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The processivity of multiubiquitination by the APC determines the order of substrate degradation.

20 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1083/JCB.200912084

Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1083/JCB.200912084

Cyclin-dependent kinase 1 gene expression is associated with poor prognosis in gastric carcinoma.

21 January 2018

1 reference

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Cyclin B2/cyclin-dependent kinase1 dissociation precedes CDK1 Thr-161 dephosphorylation upon M-phase promoting factor inactivation in Xenopus laevis cell-free extract

27 November 2018

1 reference

12 December 2020

A Role for the Fizzy/Cdc20 Family of Proteins in Activation of the APC/C Distinct from Substrate Recruitment

1 reference

12 December 2020

High expression of Cks1 in human non-small cell lung carcinomas

1 reference

12 December 2020

Role of Suc1 in the activation of the cyclosome by protein kinase Cdk1/cyclin B

1 reference

12 December 2020

The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma

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12 December 2020

Identifiers

DOI

10.1083/JCB.200912084

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20733055 AND SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20733055 AND SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

20733055

1 reference