RNAi screening comes of age: improved techniques and complementary approaches (Q28654521)

5

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author name string

Jennifer A Smith

2

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Caroline E Shamu

3

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Ralph A Neumüller

Nature Reviews Molecular Cell Biology

4

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language of work or name

English

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publication date

September 2014

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published in

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volume

15

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issue

9

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page(s)

591-600

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cites work

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Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

20 June 2018

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A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling

20 June 2018

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A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes

20 June 2018

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Genome-Wide RNAi Longevity Screens in Caenorhabditis elegans

20 June 2018

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Integration of chemical and RNAi multiparametric profiles identifies triggers of intracellular mycobacterial killing

20 June 2018

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A genome-wide RNA interference screen identifies new regulators of androgen receptor function in prostate cancer cells

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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An RNAi screen reveals intestinal regulators of branching morphogenesis, differentiation, and stem cell proliferation in planarians

20 June 2018

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20 June 2018

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siRNA off-target effects in genome-wide screens identify signaling pathway members

20 June 2018

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Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies

20 June 2018

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20 June 2018

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Single-cell analysis of population context advances RNAi screening at multiple levels

20 June 2018

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Genetic regulators of a pluripotent adult stem cell system in planarians identified by RNAi and clonal analysis

20 June 2018

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A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens

20 June 2018

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Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes

20 June 2018

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MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways.

20 June 2018

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RNA interference in Caenorhabditis elegans: uptake, mechanism, and regulation

20 June 2018

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MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes

20 June 2018

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RNAi screening: new approaches, understandings, and organisms

20 June 2018

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Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype.

20 June 2018

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Shaping cells and organs in Drosophila by opposing roles of fat body-secreted Collagen IV and perlecan

20 June 2018

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An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

20 June 2018

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The maintenance and regeneration of the planarian excretory system are regulated by EGFR signaling

20 June 2018

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Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

20 June 2018

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Mapping of signaling networks through synthetic genetic interaction analysis by RNAi

20 June 2018

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Functional identification of optimized RNAi triggers using a massively parallel sensor assay

20 June 2018

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Vigilance and validation: Keys to success in RNAi screening

20 June 2018

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Combined agonist-antagonist genome-wide functional screening identifies broadly active antiviral microRNAs

20 June 2018

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In vivo RNAi: today and tomorrow

20 June 2018

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In vivo RNAi rescue in Drosophila melanogaster with genomic transgenes from Drosophila pseudoobscura

20 June 2018

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Cross-species RNAi rescue platform in Drosophila melanogaster

20 June 2018

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Exploring the conservation of synthetic lethal genetic interaction networks

20 June 2018

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What have RNAi screens taught us about viral-host interactions?

20 June 2018

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Host cell factors in HIV replication: meta-analysis of genome-wide studies

20 June 2018

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Rapid creation and quantitative monitoring of high coverage shRNA libraries

20 June 2018

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Discovery of insect and human dengue virus host factors

20 June 2018

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Knocking down barriers: advances in siRNA delivery

20 June 2018

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Chemical modification of siRNAs for in vivo use.

20 June 2018

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An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

20 June 2018

1 reference

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Genomic RNAi screening in Drosophila S2 cells: what have we learned about host-pathogen interactions?

20 June 2018

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The art and design of genetic screens: RNA interference.

20 June 2018

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Establishment of a tissue-specific RNAi system in C. elegans

20 June 2018

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Genome-scale loss-of-function screening with a lentiviral RNAi library

20 June 2018

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shRNA libraries and their use in cancer genetics

20 June 2018

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3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

20 June 2018

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RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells

20 June 2018

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The art and design of genetic screens: mammalian culture cells

20 June 2018

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Ordering gene function: the interpretation of epistasis in regulatory hierarchies

20 June 2018

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Designing efficient and specific endoribonuclease-prepared siRNAs

20 June 2018

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Minimizing the risk of reporting false positives in large-scale RNAi screens

21 January 2018

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Molecular biology. Use and abuse of RNAi to study mammalian gene function

21 January 2018

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Systems survey of endocytosis by multiparametric image analysis

21 January 2018

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Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping.

21 January 2018

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Synthetic Genetic Array (SGA) Analysis in Saccharomyces cerevisiae and Schizosaccharomyces pombe

21 January 2018

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A Direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration

21 January 2018

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On target: A public repository for large-scale RNAi experiments

21 January 2018

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Identification of miRNA modulators to PARP inhibitor response

21 January 2018

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Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases

21 January 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204798

27 November 2018

Identifiers

DOI

10.1038/NRM3860

1 reference

Dimensions Publication ID

1041566369

0 references

1 reference

1 reference

PubMed publication ID

25145850

1 reference