Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. (Q28648056)

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17 January 2020

title

Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein (English)

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17 January 2020

2

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17 January 2020

David H. Gutmann

7

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17 January 2020

author name string

Gene Hung

3

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17 January 2020

Ali Andalibi

4

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17 January 2020

Zhijun Luo

6

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17 January 2020

Deborah N Chadee

1

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17 January 2020

David J Lim

5

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17 January 2020

John M Kyriakis

8

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17 January 2020

language of work or name

English

0 references

publication date

13 March 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16537381 AND SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

17 January 2020

number of pages

6

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

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17 January 2020

volume

103

1 reference

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17 January 2020

issue

12

1 reference

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17 January 2020

page(s)

4463-4468

1 reference

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MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation

17 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

MEK kinase activity is not necessary for Raf-1 function

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

Endothelial apoptosis in Braf-deficient mice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

Raf proteins and cancer: B-Raf is identified as a mutational target

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

Functional analysis of the relationship between the neurofibromatosis 2 tumor suppressor and its binding partner, hepatocyte growth factor-regulated tyrosine kinase substrate

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

Mixed-lineage kinase control of JNK and p38 MAPK pathways

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

Establishment and characterization of a schwannoma cell line from a patient with neurofibromatosis 2.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

Positive and negative regulation of Raf kinase activity and function by phosphorylation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

Regulation of the Neurofibromatosis Type 2 Tumor Suppressor Protein, Merlin, by Adhesion and Growth Arrest Stimuli

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450194

Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.

3 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073/PNAS.0510651103

Merlin and ERM proteins: unappreciated roles in cancer development?

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073/PNAS.0510651103

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/16537381

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0510651103

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16537381 AND SRC:MED&resulttype=core&format=json

OpenCitations bibliographic resource ID

17 January 2020

ADS bibcode

2006PNAS..103.4463C

0 references

51555

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16537381 AND SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

16537381

1 reference