Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization (Q28609061)

3 February 2017

title

Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization (English)

1 reference

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon

3 February 2017

main subject

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Heat shock protein 90 alpha family class A member 1

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Mitogen-activated protein kinase kinase 1

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Cell division cycle 37, HSP90 cochaperone

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Mitogen-activated protein kinase kinase 2

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scaffold protein binding

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Kinase suppressor of ras 1

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Dual specificity mitogen-activated protein kinase kinase mek-2 CELE_Y54E10BL.6

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Ras protein let-60 CELE_ZK792.6

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Kinase suppressor of Ras A CELE_F13B9.5

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author name string

S. Stewart

1

1 reference

3 February 2017

M. Sundaram

2

1 reference

3 February 2017

Y. Zhang

3

1 reference

3 February 2017

J. Lee

4

1 reference

3 February 2017

M. Han

5

1 reference

3 February 2017

K. L. Guan

6

1 reference

3 February 2017

language of work or name

English

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publication date

1 August 1999

1 reference

Molecular and Cellular Biology

3 February 2017

published in

1 reference

3 February 2017

volume

19

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3 February 2017

issue

8

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3 February 2017

page(s)

5523–5534

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A mammalian scaffold complex that selectively mediates MAP kinase activation

3 February 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Murine Ksr interacts with MEK and inhibits Ras-induced transformation

17 March 2017

1 reference

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In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone

17 March 2017

1 reference

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Cdc37 is a molecular chaperone with specific functions in signal transduction

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Kinase suppressor of Ras is ceramide-activated protein kinase

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

KSR modulates signal propagation within the MAPK cascade

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

KSR, a novel protein kinase required for RAS signal transduction

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Mammalian Ras interacts directly with the serine/threonine kinase Raf

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Activation of ternary complex factor Elk-1 by MAP kinases

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

p21 is a universal inhibitor of cyclin kinases

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Cytoplasmic localization of the mitogen-activated protein kinase activator MEK

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2.

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

The genetics of Caenorhabditis elegans

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Mitogen-activated protein kinase pathways

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

KSR stimulates Raf-1 activity in a kinase-independent manner

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

The calcium/calmodulin-dependent protein phosphatase calcineurin is the major Elk-1 phosphatase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Signal transduction from multiple Ras effectors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Receptor protein-tyrosine kinases and their signal transduction pathways

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Transcriptional regulation by extracellular signals: mechanisms and specificity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

The protein kinase KSR interacts with 14-3-3 protein and Raf.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397

Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/10409742

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/10409742

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.19.8.5523

0 references

PMC publication ID

84397

0 references

1 reference