PP4 is essential for germinal center formation and class switch recombination in mice (Q28542954)

1

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Ya-Ping Chen

2

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Ming-Sian Wu

3

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Guanni-Yi Yu

4

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Tse-Hua Tan

6

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Yu-Wen Su

Creative Commons Attribution 4.0 International

7

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language of work or name

English

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publication date

2014

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published in

PLOS One

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volume

9

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issue

9

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page(s)

e107505

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copyright license

start time

12 September 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6

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A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication

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A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery

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Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4.

19 March 2017

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Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity

19 March 2017

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The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation

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53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

19 March 2017

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

7 April 2017

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Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

7 April 2017

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Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair

29 September 2017

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The serine/threonine phosphatase PP4 is required for pro-B cell development through its promotion of immunoglobulin VDJ recombination

29 September 2017

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Protein phosphatase PP4 is involved in NHEJ-mediated repair of DNA double-strand breaks.

29 September 2017

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Overexpression of protein phosphatase 4 correlates with poor prognosis in patients with stage II pancreatic ductal adenocarcinoma

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Germinal center selection and the development of memory B and plasma cells

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Germinal center B-cells.

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29 September 2017

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B Cell-Specific Expression of B7-2 Is Required for Follicular Th Cell Function in Response to Vaccinia Virus

29 September 2017

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T cells and follicular dendritic cells in germinal center B-cell formation and selection.

29 September 2017

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Follicular B cell trafficking within the spleen actively restricts humoral immune responses

29 September 2017

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Differential localization and function of PB1-F2 derived from different strains of influenza A virus

29 September 2017

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Switch region identity plays an important role in Ig class switch recombination

29 September 2017

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Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells.

29 September 2017

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Non-homologous end joining in class switch recombination: the beginning of the end

29 September 2017

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Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162579

Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162579

Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation

29 September 2017

1 reference

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Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation

29 September 2017

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Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation

29 September 2017

1 reference

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Protein phosphatase 4 is involved in tumor necrosis factor-alpha-induced activation of c-Jun N-terminal kinase

29 September 2017

1 reference

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Activation of mitogen-activated protein kinases via CD40 is distinct from that stimulated by surface IgM on B cells

29 September 2017

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Clonal selection and learning in the antibody system

29 September 2017

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Quantitation of immunoglobulin mu-gamma 1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method

29 September 2017

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Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162579

Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162579

Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell receptor signaling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162579

Stable RNA/DNA hybrids in the mammalian genome: inducible intermediates in immunoglobulin class switch recombination

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162579

Protein phosphatase 4 is an essential enzyme required for organisation of microtubules at centrosomes in Drosophila embryos

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162579

The immunoglobulin class switch: beyond "accessibility".

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162579

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162579

A PP4 holoenzyme balances physiological and oncogenic nuclear factor-kappa B signaling in T lymphocytes.

3 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0107505

Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0107505

Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0107505

Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis in C. elegans

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162579

B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162579

Protein phosphatase PP4 is overexpressed in human breast and lung tumors

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25215539