Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways (Q28533401)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24068907 AND SRC:MED&resulttype=core&format=json

23 February 2020

title

Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24068907 AND SRC:MED&resulttype=core&format=json

23 February 2020

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24068907 AND SRC:MED&resulttype=core&format=json

23 February 2020

Jing Tang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24068907 AND SRC:MED&resulttype=core&format=json

23 February 2020

Leena Karhinen

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24068907 AND SRC:MED&resulttype=core&format=json

23 February 2020

Tero Aittokallio

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24068907 AND SRC:MED&resulttype=core&format=json

23 February 2020

4

Agnieszka Szwajda

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24068907 AND SRC:MED&resulttype=core&format=json

23 February 2020

author name string

Tao Xu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24068907 AND SRC:MED&resulttype=core&format=json

23 February 2020

Bhagwan Yadav

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24068907 AND SRC:MED&resulttype=core&format=json

23 February 2020

language of work or name

English

0 references

publication date

12 September 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24068907 AND SRC:MED&resulttype=core&format=json

PLOS Computational Biology

23 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24068907 AND SRC:MED&resulttype=core&format=json

23 February 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24068907 AND SRC:MED&resulttype=core&format=json

23 February 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24068907 AND SRC:MED&resulttype=core&format=json

23 February 2020

page(s)

e1003226

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24068907 AND SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

23 February 2020

copyright license

start time

12 September 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Prediction of drug combinations by integrating molecular and pharmacological data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

ChEMBL: a large-scale bioactivity database for drug discovery

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Statistical methods for analysis of high-throughput RNA interference screens

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Synthetic lethality--a new direction in cancer-drug development

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Network pharmacology: the next paradigm in drug discovery

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

A quantitative analysis of kinase inhibitor selectivity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

The concept of synthetic lethality in the context of anticancer therapy

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Novel computational approaches to polypharmacology as a means to define responses to individual drugs

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

A side effect resource to capture phenotypic effects of drugs

23 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Comprehensive analysis of kinase inhibitor selectivity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Advances in understanding cancer genomes through second-generation sequencing

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Network pharmacology strategies toward multi-target anticancer therapies: from computational models to experimental design principles

9 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Combinatorial drug therapy for cancer in the post-genomic era.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Exploring drug combinations in genetic interaction network

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

The MEK1/2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

A kinase inhibition map approach for tumor sensitivity prediction and combination therapy design for targeted drugs.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

PubChem's BioAssay Database

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Dynamical and structural analysis of a T cell survival network identifies novel candidate therapeutic targets for large granular lymphocyte leukemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Kinome-wide siRNA screening identifies molecular targets mediating the sensitivity of pancreatic cancer cells to Aurora kinase inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Model-based global sensitivity analysis as applied to identification of anti-cancer drug targets and biomarkers of drug resistance in the ErbB2/3 network

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Systematic exploration of synergistic drug pairs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Modulatory profiling identifies mechanisms of small molecule-induced cell death.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Predicting selective drug targets in cancer through metabolic networks.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

The productivity crisis in pharmaceutical R&D.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Principles and strategies for developing network models in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Searching for synthetic lethality in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

A mammalian functional-genetic approach to characterizing cancer therapeutics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Targeting the cancer kinome through polypharmacology

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

RNAi screening: tips and techniques

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Synergistic drug combinations tend to improve therapeutically relevant selectivity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Finding multiple target optimal intervention in disease-related molecular network.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Models from experiments: combinatorial drug perturbations of cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Defining genetic interaction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Rational design of cancer-drug combinations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Synthetic lethal screen identification of chemosensitizer loci in cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Prediction of drug combination chemosensitivity in human bladder cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Strategies for optimizing combinations of molecularly targeted anticancer agents

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

AURKA is one of the downstream targets of MAPK1/ERK2 in pancreatic cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Overcoming erlotinib resistance with tailored treatment regimen in patient-derived xenografts from naïve Asian NSCLC patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

PROMISCUOUS: a database for network-based drug-repositioning

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

Analysis of cell-based RNAi screens.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772058

High drug attrition rates--where are we going wrong?

2 June 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PCBI.1003226

Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PCBI.1003226

Functional classification of drugs by properties of their pairwise interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PCBI.1003226

Interrogating the kinome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PCBI.1003226

Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PCBI.1003226

Detecting drug targets with minimum side effects in metabolic networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PCBI.1003226

Mechanisms of drug combinations: interaction and network perspectives

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24068907

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Genetic Interactions in Cancer Progression and Treatment

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24068907

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PCBI.1003226

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24068907 AND SRC:MED&resulttype=core&format=json

journals/ploscb/TangKXSYWA13

23 February 2020

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

release_ijqxgzntjffppaymzqizp7ykry

28 January 2021

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ijqxgzntjffppaymzqizp7ykry

mapped directly with Wikidata item

24 November 2022

based on heuristic

OpenCitations bibliographic resource ID

3862344

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

3862344

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24068907 AND SRC:MED&resulttype=core&format=json

23 February 2020

PubMed publication ID

24068907

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24068907 AND SRC:MED&resulttype=core&format=json