Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth (Q28511330)

25 January 2017

title

Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth (English)

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Cyclin-dependent kinase inhibitor 1A (P21)

25 January 2017

main subject

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Transformed mouse 3T3 cell double minute 4

GOA release 2020-03-11

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GOA release 2020-03-11

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Heather A. Steinman

1

1 reference

25 January 2017

Hayla K. Sluss

2

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25 January 2017

Arthur T. Sands

3

1 reference

25 January 2017

German Pihan

4

1 reference

25 January 2017

Stephen N. Jones

5

1 reference

25 January 2017

language of work or name

English

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publication date

8 January 2004

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25 January 2017

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25 January 2017

volume

23

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25 January 2017

issue

1

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25 January 2017

page(s)

303–306

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Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

25 January 2017

cites work

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206925

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206925

Regulation and function of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206925

The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206925

mdm2 expression is induced by wild type p53 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206925

7 January 2021

Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206925

7 January 2021

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206925

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206925

7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206925

7 January 2021

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206925

7 January 2021

Deletion of p21 cannot substitute for p53 loss in rescue of mdm2 null lethality

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206925

7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206925

7 January 2021

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206925

7 January 2021

The p53-mdm-2 autoregulatory feedback loop

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206925

7 January 2021