Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development (Q28510142)

24 January 2017

title

Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development (English)

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24 January 2017

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J. R. Seavitt

1

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24 January 2017

L. S. White

2

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24 January 2017

K. M. Murphy

3

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24 January 2017

D. Y. Loh

4

1 reference

24 January 2017

R. M. Perlmutter

5

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24 January 2017

M. L. Thomas

6

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24 January 2017

language of work or name

English

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publication date

1 June 1999

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Molecular and Cellular Biology

24 January 2017

published in

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24 January 2017

volume

19

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24 January 2017

issue

6

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24 January 2017

page(s)

4200–4208

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CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion

24 January 2017

cites work

1 reference

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CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4 CD8 thymocytes, and B cell maturation

19 March 2017

1 reference

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Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice

19 March 2017

1 reference

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CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases

19 March 2017

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Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines

19 March 2017

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Profound block in thymocyte development in mice lacking p56lck

19 March 2017

1 reference

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Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

19 March 2017

1 reference

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Signal transduction by lymphocyte antigen receptors

19 March 2017

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Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

7 April 2017

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Mutational analysis of Lck in CD45-negative T cells: dominant role of tyrosine 394 phosphorylation in kinase activity

9 May 2017

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Regulation of lymphocyte function by protein phosphorylation

29 September 2017

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Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck, fyn, and c-src tyrosine protein kinases

29 September 2017

1 reference

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Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor

29 September 2017

1 reference

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CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.

29 September 2017

1 reference

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The protein tyrosine kinase p56lck regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors [corrected]

29 September 2017

1 reference

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A dominant-negative transgene defines a role for p56lck in thymopoiesis

29 September 2017

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The role of p56lck and p59fyn tyrosine kinases and CD45 protein tyrosine phosphatase in T-cell development and clonal selection

29 September 2017

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CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development

29 September 2017

1 reference

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Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts

29 September 2017

1 reference

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Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases

29 September 2017

1 reference

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Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase

29 September 2017

1 reference

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Coclustering CD45 with CD4 or CD8 alters the phosphorylation and kinase activity of p56lck

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104379

Delayed thymocyte development induced by augmented expression of p56lck

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104379

Thymic tumorigenesis induced by overexpression of p56lck

29 September 2017

1 reference

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Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104379

CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104379

Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104379

Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104379

Induction by antigen of intrathymic apoptosis of CD4 CD8 TCRlo thymocytes in vivo

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104379

Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104379

Regulation of c-Src tyrosine kinase activity by the Src SH2 domain

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104379

Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

27 November 2018

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12 December 2020

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

1 reference

12 December 2020

Positive and negative selection of T lymphocytes

1 reference

12 December 2020

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56 lck

1 reference

12 December 2020

Protein tyrosine kinase p56 lck controls allelic exclusion of T-cell receptor β-chain genes

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12 December 2020

CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells

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12 December 2020

Activation of the Lck Tyrosine Kinase Targets Cell Surface T Cell Antigen Receptors for Lysosomal Degradation

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12 December 2020

Cutting edge: the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.19.6.4200

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PMC publication ID

104379

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1 reference