B-Raf-mediated signaling pathway regulates T cell development (Q28507477)

24 January 2017

title

B-Raf-mediated signaling pathway regulates T cell development (English)

1 reference

24 January 2017

main subject

Braf transforming gene

1 reference

GOA release 2020-03-11

author name string

Hirotake Tsukamoto

1

1 reference

24 January 2017

Atsushi Irie

2

1 reference

24 January 2017

Satoru Senju

3

1 reference

24 January 2017

Antonis K. Hatzopoulos

4

1 reference

24 January 2017

Leszek Wojnowski

5

1 reference

24 January 2017

Yasuharu Nishimura

6

1 reference

24 January 2017

language of work or name

English

0 references

publication date

1 February 2008

1 reference

European Journal of Immunology

24 January 2017

published in

1 reference

24 January 2017

volume

38

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24 January 2017

issue

2

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24 January 2017

page(s)

518–527

1 reference

Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF

24 January 2017

cites work

1 reference

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A critical function for B-Raf at multiple stages of myelopoiesis

19 March 2017

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Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis

19 March 2017

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Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

19 March 2017

1 reference

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Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Endothelial apoptosis in Braf-deficient mice

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

19 March 2017

1 reference

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Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

TCR ligand avidity determines the mode of B-Raf/Raf-1/ERK activation leading to the activation of human CD4 T cell clone.

29 September 2017

1 reference

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A requirement for sustained ERK signaling during thymocyte positive selection in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Transcriptional modulation of TCR, Notch and Wnt signaling pathways in SEB-anergized CD4 T cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

B-Raf contributes to sustained extracellular signal-regulated kinase activation associated with interleukin-2 production stimulated through the T cell receptor.

29 September 2017

1 reference

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Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation

29 September 2017

1 reference

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The Ras/MAPK cascade and the control of positive selection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Positive and negative selection of T cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Maintaining the norm: T-cell homeostasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

T-cell development and the CD4-CD8 lineage decision

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

CD28 and the tyrosine kinase lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Isotype-specific functions of Raf kinases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Pleiotropic changes controlled by the pre-T-cell receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Positive and negative selection invoke distinct signaling pathways.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Raf-1 is required for T cell IL2 production.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Development of hematopoietic stem cell activity in the mouse embryo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Involvement of p21ras distinguishes positive and negative selection in thymocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

The mouse B-raf gene encodes multiple protein isoforms with tissue-specific expression.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Expression and activation of B-Raf kinase isoforms in human and murine leukemia cell lines

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

The role of erk1 and erk2 in multiple stages of T cell development

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Vav1 Transduces T Cell Receptor Signals to the Activation of the Ras/ERK Pathway via LAT, Sos, and RasGRP1

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Activation of the extracellular signal-related kinase/mitogen-activated protein kinase pathway discriminates CD4 versus CD8 lineage commitment in the thymus.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

CD69 expression during selection and maturation of CD4 8 thymocytes.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706025

Ectopic B-Raf expression enhances extracellular signal-regulated kinase (ERK) signaling in T cells and prevents antigen-presenting cell-induced anergy

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/18228248

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Activity of both Raf and Ras is necessary for activation of transcription of the human T cell receptor beta gene by protein kinase C, Ras plays multiple roles

1 reference

https://pubmed.ncbi.nlm.nih.gov/18228248

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Raf regulates positive selection

1 reference

https://pubmed.ncbi.nlm.nih.gov/18228248

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/EJI.200737430

0 references

PMC publication ID

2706025

0 references

1 reference