The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1 (Q28505266)

24 January 2017

title

The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1 (English)

1 reference

Protein tyrosine phosphatase, non-receptor type 12

24 January 2017

0 references

1 reference

IQ motif containing GTPase activating protein 1

GOA release 2020-03-11

1 reference

Src homology 2 domain-containing transforming protein C1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Mitsuhiko Ikura

9

0 references

Pavel Metalnikov

6

0 references

Marilyn Goudreault

4

0 references

Andrei Starostine

7

0 references

Anthony Pawson

8

0 references

Matthew J. Smith

object named as

Matthew J. Smith

1

0 references

Steven M Hersch

5

object named as

Steven Hersch

1 reference

24 January 2017

W. Rod Hardy

2

1 reference

24 January 2017

Guang-Yao Li

3

1 reference

24 January 2017

language of work or name

English

0 references

publication date

3 March 2010

1 reference

24 January 2017

1 reference

24 January 2017

volume

29

1 reference

24 January 2017

issue

5

1 reference

24 January 2017

page(s)

884–896

1 reference

Crystal structure of the GTPase-activating protein-related domain from IQGAP1

24 January 2017

cites work

1 reference

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Coupling of folding and binding in the PTB domain of the signaling protein Shc

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Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170

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FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors

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PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates

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19 March 2017

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The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo

19 March 2017

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19 March 2017

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The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation

19 March 2017

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Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity

19 March 2017

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Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion

19 March 2017

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Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA

19 March 2017

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Distinct Tyrosine Autophosphorylation Sites Negatively and Positively Modulate Neu-Mediated Transformation

19 March 2017

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IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments

19 March 2017

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Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation

19 March 2017

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A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3

19 March 2017

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The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions

19 March 2017

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Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1

19 March 2017

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Phosphotyrosine-independent binding of SHC to the NPLH sequence of murine protein-tyrosine phosphatase-PEST. Evidence for extended phosphotyrosine binding/phosphotyrosine interaction domain recognition specificity

19 March 2017

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Structure and ligand recognition of the phosphotyrosine binding domain of Shc

19 March 2017

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19 March 2017

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Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins

19 March 2017

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Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes

19 March 2017

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Interaction of Shc with Grb2 regulates association of Grb2 with mSOS

19 March 2017

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A novel approach for sequential assignment of 1H, 13C, and 15N spectra of proteins: heteronuclear triple-resonance three-dimensional NMR spectroscopy. Application to calmodulin

19 March 2017

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A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

19 March 2017

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IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837165

Silencing of IQGAP1 by shRNA inhibits the invasion of ovarian carcinoma HO-8910PM cells in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837165

Combinatorial ShcA docking interactions support diversity in tissue morphogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837165

Multiple proteins mediate IQGAP1-stimulated cell migration

29 September 2017

1 reference

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IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837165

Targeting of calcium:calmodulin signals to the cytoskeleton by IQGAP1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837165

IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837165

Crosstalk coregulation mechanisms of G protein-coupled receptors and receptor tyrosine kinases

29 September 2017

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Self-association of IQGAP1: characterization and functional sequelae

29 September 2017

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Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation

29 September 2017

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Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival

29 September 2017

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Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.

29 September 2017

1 reference

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Structural and evolutionary division of phosphotyrosine binding (PTB) domains.

29 September 2017

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29 September 2017

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29 September 2017

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Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact

29 September 2017

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Coactivation of Rac1 and Cdc42 at lamellipodia and membrane ruffles induced by epidermal growth factor.

29 September 2017

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Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion

29 September 2017

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ERK activation and alpha v beta 3 integrin signaling through Shc recruitment in response to mechanical stimulation in human osteoblasts

29 September 2017

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Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer

29 September 2017

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Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes

29 September 2017

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Adaptor protein Shc undergoes translocation and mediates up-regulation of the tyrosine kinase c-Src in EGF-stimulated A431 cells

29 September 2017

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The shc adaptor protein forms interdependent phosphotyrosine-mediated protein complexes in mast cells stimulated with interleukin 3.

29 September 2017

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Bifurcation of cell migratory and proliferative signaling by the adaptor protein Shc.

29 September 2017

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The function of PTB domain proteins

29 September 2017

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Diversity in protein recognition by PTB domains

29 September 2017

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Requirement for Shc in TCR-mediated activation of a T cell hybridoma

29 September 2017

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Cdc42, Rac1, and their effector IQGAP1 as molecular switches for cadherin-mediated cell-cell adhesion.

29 September 2017

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Functional roles of the Shc phosphotyrosine binding and Src homology 2 domains in insulin and epidermal growth factor signaling

29 September 2017

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Sch proteins are localized on endoplasmic reticulum membranes and are redistributed after tyrosine kinase receptor activation.

29 September 2017

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Amino acid type determination in the sequential assignment procedure of uniformly 13C/15N-enriched proteins.

29 September 2017

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An efficient triple-resonance experiment for proton-directed sequential backbone assignment of medium-sized proteins

29 September 2017

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A Drosophila shc Gene Product Is Implicated in Signaling by the DER Receptor Tyrosine Kinase

29 September 2017

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Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene

29 September 2017

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Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation

29 September 2017

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IQGAP1 promotes cell motility and invasion

2 June 2018

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Ret oncogene signal transduction via a IRS-2/PI 3-kinase/PKB and a SHC/Grb-2 dependent pathway: possible implication for transforming activity in NIH3T3 cells

2 June 2018

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Identification of shc as the primary protein binding to the tyrosine-phosphorylated beta 3 subunit of alpha IIbbeta 3 during outside-in integrin platelet signaling

2 June 2018

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SHC-alpha5beta1 integrin interactions regulate breast cancer cell adhesion and motility

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837165

The adaptor protein Shc couples a class of integrins to the control of cell cycle progression

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837165

Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837165

Tyrosine phosphorylation of Shc is induced by IL-3, IL-5 and GM-CSF.

2 June 2018

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Natural abundance nitrogen-15 NMR by enhanced heteronuclear spectroscopy

2 June 2018

1 reference

https://api.crossref.org/works/10.1038/EMBOJ.2009.399

Enhanced insulin signaling via Shc in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/EMBOJ.2009.399

Lck couples Shc to TCR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/EMBOJ.2009.399

Distinct tyrosine autophosphorylation sites mediate induction of epithelial mesenchymal like transition by an activated ErbB-2/Neu receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/EMBOJ.2009.399

The dual-function disabled-1 PTB domain exhibits site independence in binding phosphoinositide and peptide ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/EMBOJ.2009.399

Src homologous and collagen (Shc) protein binds to F-actin and translocates to the cytoskeleton upon nerve growth factor stimulation in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/EMBOJ.2009.399

IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/EMBOJ.2009.399

Interaction of EGF receptor and grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy

21 January 2018

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12 December 2020

Binding affinities of tyrosine-phosphorylated peptides to the COOH-terminal SH2 and NH2-terminal phosphotyrosine binding domains of Shc

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12 December 2020

G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases

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12 December 2020

Interleukin 5 Signals through Shc and Grb2 in Human Eosinophils

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12 December 2020

Differential regulation of SHC proteins by nerve growth factor in sensory neurons and PC12 cells

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12 December 2020

IQGAP1 integrates Ca2 /calmodulin and Cdc42 signaling

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12 December 2020

Role of Interleukin (IL)-2 Receptor β-Chain Subdomains and Shc in p38 Mitogen-activated Protein (MAP) Kinase and p54 MAP Kinase (Stress-activated Protein Kinase/c-Jun N-terminal Kinase) Activation

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12 December 2020

p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells

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12 December 2020

Identifiers

DOI

10.1038/EMBOJ.2009.399

1 reference

1 reference

1 reference

1 reference