Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319 (Q28487909)

1

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John M Beals

2

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Radmila Micanovic

3

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Beth A Strifler

4

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Radhakrishnan Rathnachalam

5

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Victor J Wroblewski

6

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Shun Li

7

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Anja Koester

8

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Amy M Ford

9

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Tamer Coskun

10

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James D Dunbar

11

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Christine C Cheng

12

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Christopher C Frye

13

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Thomas F Bumol

14

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David E Moller

Creative Commons Attribution 4.0 International

15

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language of work or name

English

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publication date

2013

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published in

PLOS One

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volume

8

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issue

3

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page(s)

e58575

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copyright license

start time

11 March 2013

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Different roles of N- and C- termini in the functional activity of FGF21

19 March 2017

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BetaKlotho is required for metabolic activity of fibroblast growth factor 21

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Klotho converts canonical FGF receptor into a specific receptor for FGF23

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FGF-21 as a novel metabolic regulator

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Identification of a novel FGF, FGF-21, preferentially expressed in the liver

19 March 2017

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19 March 2017

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29 September 2017

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FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents

29 September 2017

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Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes

29 September 2017

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FGF21 reloaded: challenges of a rapidly growing field

29 September 2017

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29 September 2017

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The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.

29 September 2017

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Recombinant expression systems in the pharmaceutical industry

29 September 2017

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Peroxisomal Targeting, Import, and Assembly of Alcohol Oxidase in Pichia pastoris

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Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

21 January 2018

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Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys

21 January 2018

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Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency

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Solvent effects on the solubility and physical stability of human insulin-like growth factor I

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Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21

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[Optimization and characterization of a novel FGF21 mutant]

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Interleukin-1 receptor (IL-1R) liquid formulation development using differential scanning calorimetry

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10.1371/JOURNAL.PONE.0058575

Identifiers

DOI

1 reference

ADS bibcode

2013PLoSO...858575K

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1 reference

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PubMed publication ID

23536797

1 reference