Lapatinib-binding protein kinases in the African trypanosome: identification of cellular targets for kinase-directed chemical scaffolds (Q28486270)

5 February 2019

tousled-like kinase I

1 reference

casein kinase I, isoform 2

5 February 2019

1 reference

Lapatinib-binding protein kinase 4

5 February 2019

1 reference

mitogen-activated protein kinase kinase kinase, putative

6 February 2019

1 reference

6 February 2019

7

Ruben Abagyan

0 references

Michael P. Pollastri

object named as

Michael Pollastri

6

0 references

Irina Kufareva

object named as

Irina Kufareva

2

0 references

author name string

Samiksha Katiyar

1

0 references

Ranjan Behera

3

0 references

Sarah M Thomas

4

0 references

Yuko Ogata

5

0 references

Kojo Mensa-Wilmot

Creative Commons Attribution 4.0 International

8

0 references

language of work or name

English

0 references

publication date

2013

0 references

published in

PLOS One

0 references

volume

8

0 references

issue

2

0 references

page(s)

e56150

0 references

copyright license

start time

20 February 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas

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7 April 2017

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AEE788 is a vascular endothelial growth factor receptor tyrosine kinase inhibitor with antiproliferative and proapoptotic effects in acute myeloid leukemia.

29 September 2017

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A guided tour of the Trans-Proteomic Pipeline

29 September 2017

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The phosphoproteome of bloodstream form Trypanosoma brucei, causative agent of African sleeping sickness

29 September 2017

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Protein kinase inhibitors: contributions from structure to clinical compounds

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An overview of the qualitative analysis of phosphoproteins by mass spectrometry

29 September 2017

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A comprehensive analysis of Trypanosoma brucei mitochondrial proteome

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Human African trypanosomiasis: pharmacological re-engagement with a neglected disease.

29 September 2017

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29 September 2017

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29 September 2017

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New developments in human African trypanosomiasis

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Lessons from the drug discovery of lapatinib, a dual ErbB1/2 tyrosine kinase inhibitor

29 September 2017

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29 September 2017

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Role of tyrosine kinase inhibitors in cancer therapy

29 September 2017

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29 September 2017

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Axenic culture of African trypanosome bloodstream forms

29 September 2017

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AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity

29 September 2017

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CI-1033, a pan-erbB tyrosine kinase inhibitor

29 September 2017

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Prediction of the binding energy for small molecules, peptides and proteins

29 September 2017

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The STK2 gene, which encodes a putative Ser/Thr protein kinase, is required for high-affinity spermidine transport in Saccharomyces cerevisiae

29 September 2017

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PK12, a plant dual-specificity protein kinase of the LAMMER family, is regulated by the hormone ethylene

29 September 2017

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Biased probability Monte Carlo conformational searches and electrostatic calculations for peptides and proteins

29 September 2017

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p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15

29 September 2017

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29 September 2017

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Development of a new physics‐based internal coordinate mechanics force field and its application to protein loop modeling

2 June 2018

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Phosphotyrosine Signaling: Evolving a New Cellular Communication System

2 June 2018

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Casein kinase 1 isoform 2 is essential for bloodstream form Trypanosoma brucei

2 June 2018

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Identification and specific localization of tyrosine-phosphorylated proteins in Trypanosoma brucei.

2 June 2018

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Evidence of Tyrosine Kinase Activity in the Protozoan ParasiteTrypanosoma brucei

2 June 2018

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A randomized, phase II, dose-finding study of the pan-ErbB receptor tyrosine-kinase inhibitor CI-1033 in patients with pretreated metastatic breast cancer

2 June 2018

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The pan-ErbB receptor tyrosine kinase inhibitor canertinib induces ErbB-independent apoptosis in human leukemia (HL-60 and U-937) cells

21 January 2018

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Interferon-gamma induces secretion of trypanosome lymphocyte triggering factor via tyrosine protein kinases

21 January 2018

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Glycosylphosphatidylinositol-specific phospholipase C regulates transferrin endocytosis in the African trypanosome

21 January 2018

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21 January 2018

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ICM?A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation

21 January 2018

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PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

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Tyrosine kinase inhibitors. 18. 6-Substituted 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as soluble, irreversible inhibitors of the epidermal growth factor receptor

21 January 2018

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Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways

21 January 2018

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Administration of CI-1033, an irreversible pan-erbB tyrosine kinase inhibitor, is feasible on a 7-day on, 7-day off schedule: a phase I pharmacokinetic and food effect study

21 January 2018

1 reference

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AEE788, a dual tyrosine kinase receptor inhibitor, induces endothelial cell apoptosis in human cutaneous squamous cell carcinoma xenografts in nude mice

21 January 2018

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Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the hum

21 January 2018

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Design of EGFR kinase inhibitors: A ligand-based approach and its confirmation with structure-based studies

21 January 2018

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Assignment of the bovine receptor-interacting serine-threonine kinase 2 gene (RIPK2) to BTA14 with somatic and radiation cell hybrids

21 January 2018

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A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.

21 January 2018

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Cellular targets of gefitinib

21 January 2018

1 reference

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Homology modeling with internal coordinate mechanics: Deformation zone mapping and improvements of models via conformational search

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23437089

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Transferrin is a growth factor for the bloodstream form ofTrypanosoma brucei

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23437089

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0056150

1 reference

ADS bibcode

2013PLoSO...856150K

0 references

1 reference

1 reference

PubMed publication ID

23437089

1 reference