Metformin in obesity, cancer and aging: addressing controversies (Q28480735)

19 March 2019

24 March 2019

3 April 2019

20 August 2019

7 November 2019

27 October 2020

on focus list of Wikimedia project

8 February 2021

ScienceSource

0 references

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Molecular damage in cancer: an argument for mTOR-driven aging

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Of mice and men: the benefits of caloric restriction, exercise, and mimetics.

29 September 2017

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Relationship of type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity.

29 September 2017

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Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program

29 September 2017

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Use of metformin is not associated with a decreased risk of colorectal cancer: a case-control analysis

29 September 2017

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Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer

29 September 2017

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Lower risk of cancer in patients on metformin in comparison with those on sulfonylurea derivatives: results from a large population-based follow-up study

29 September 2017

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Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling

29 September 2017

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Obesity and insulin resistance in breast cancer – Chemoprevention strategies with a focus on metformin

29 September 2017

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Relevance of the OCT1 transporter to the antineoplastic effect of biguanides

29 September 2017

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Effectiveness of Primary Care–Relevant Treatments for Obesity in Adults: A Systematic Evidence Review for the U.S. Preventive Services Task Force

29 September 2017

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Reduced risk of colorectal cancer with metformin therapy in patients with type 2 diabetes: a meta-analysis

29 September 2017

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Weight beneficial treatments for type 2 diabetes

29 September 2017

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Metformin as a geroprotector.

29 September 2017

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Effect of metformin on survival outcomes in diabetic patients with triple receptor‐negative breast cancer

29 September 2017

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Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations

29 September 2017

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[Metformin slows down ageing processes at the cellular level in SHR mice].

29 September 2017

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Review of the literature and suggestions for the design of rodent survival studies for the identification of compounds that increase health and life span

29 September 2017

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Metformin Induces Both Caspase-Dependent and Poly(ADP-ribose) Polymerase-Dependent Cell Death in Breast Cancer Cells

29 September 2017

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If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.

29 September 2017

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Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals

29 September 2017

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Effects of metformin on body weight and body composition in obese insulin-resistant children: a randomized clinical trial

29 September 2017

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Metformin and sex: Why suppression of aging may be harmful to young male mice

29 September 2017

1 reference

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Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

29 September 2017

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Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice

29 September 2017

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Metformin for aging and cancer prevention

29 September 2017

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OCT1 Expression in adipocytes could contribute to increased metformin action in obese subjects.

29 September 2017

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Metformin and other biguanides in oncology: advancing the research agenda

29 September 2017

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Modern Approach to Metabolic Rehabilitation of Cancer Patients: Biguanides (Phenformin and Metformin) and Beyond

29 September 2017

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Calorie restriction: what recent results suggest for the future of ageing research

29 September 2017

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Experience of malignancies with oral glucose-lowering drugs in the randomised controlled ADOPT (A Diabetes Outcome Progression Trial) and RECORD (Rosiglitazone Evaluated for Cardiovascular Outcomes and Regulation of Glycaemia in Diabetes) clinical t

29 September 2017

1 reference

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Metformin supplementation and life span in Fischer-344 rats

29 September 2017

1 reference

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Validation of anti-aging drugs by treating age-related diseases

29 September 2017

1 reference

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Antidiabetic oral treatment in older people: does frailty matter?

29 September 2017

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29 September 2017

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Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database.

29 September 2017

1 reference

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The influence of glucose-lowering therapies on cancer risk in type 2 diabetes

29 September 2017

1 reference

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29 September 2017

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Insulin sensitizing drugs for weight loss in women of reproductive age who are overweight or obese: systematic review and meta-analysis.

29 September 2017

1 reference

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Meta-analysis: metformin treatment in persons at risk for diabetes mellitus

29 September 2017

1 reference

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Screening candidate longevity therapeutics using gene-expression arrays

29 September 2017

1 reference

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Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans

29 September 2017

1 reference

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Metformin as treatment for overweight and obese adults: a systematic review

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

Preventing cancer, cardiovascular disease, and diabetes: a common agenda for theAmerican Cancer Society, the American Diabetes Association, and the American Heart Association

29 September 2017

1 reference

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Metabolic and body composition factors in subgroups of obesity: what do we know?

29 September 2017

1 reference

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Potential contribution of metformin to the management of cardiovascular disease risk in patients with abdominal obesity, the metabolic syndrome and type 2 diabetes

29 September 2017

1 reference

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Newborn macrosomy and cancer.

29 September 2017

1 reference

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Ageing, metabolic immunodepression and carcinogenesis

29 September 2017

1 reference

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Pharmacological mimicking of caloric restriction elicits epigenetic reprogramming of differentiated cells to stem-like self-renewal states.

29 September 2017

1 reference

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Metformin induces oxidative stress in white adipocytes and raises uncoupling protein 2 levels

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin.

2 June 2018

1 reference

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Age-associated elevation of hypothalamic, threshold to feedback control, and its role in development, ageine, and disease

2 June 2018

1 reference

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Variations in mortality by weight among 750,000 men and women

2 June 2018

1 reference

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Cancer research. Cancer prevention with a diabetes pill?

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

Cancer mortality reduction and metformin: a retrospective cohort study in type 2 diabetic patients.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

Metformin and incident breast cancer among diabetic women: a population-based case-control study in Denmark

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

Clinical outcomes after radical prostatectomy in diabetic patients treated with metformin

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

The issue of feasibility of a general theory of aging. III. The theory and practice of aging

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

Metformin slows down aging and extends life span of female SHR mice.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

Cancer and aging: more puzzles, more promises?

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

Metformin as first choice in oral diabetes treatment: the UKPDS experience.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

Metformin therapy in a transgenic mouse model of Huntington's disease.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

Randomized, controlled trial of metformin for obesity and insulin resistance in children and adolescents: improvement in body composition and fasting insulin

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

Weight loss effect on inflammation and LDL oxidation in metabolically healthy but obese (MHO) individuals: low inflammation and LDL oxidation in MHO women.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

Biochemistry of lifespan extension

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

THE EFFECT OF METFORMIN ON WEIGHT LOSS IN OBESITY

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384433

Nutrition in relation to cancer

27 November 2018

1 reference

12 December 2020

Comparison of two doses of metformin (2.5 and 1.5 g/day) for the treatment of polycystic ovary syndrome and their effect on body mass index and waist circumference

1 reference

12 December 2020

Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus

1 reference

12 December 2020

Metformin and the Incidence of Prostate Cancer in Patients with Type 2 Diabetes

1 reference

12 December 2020

Diabetes, treatments for diabetes and their effect on cancer incidence and mortality: attempts to disentangle the web of associations

1 reference

12 December 2020

A prospective, randomized pilot study evaluating the effects of metformin and lifestyle intervention on patients with prostate cancer receiving androgen deprivation therapy

1 reference

12 December 2020

[Effectiveness of aromatase inhibitors in comparison with metformin for neoadjuvant treatment in patients with endometrial cancer]

1 reference

12 December 2020

Preliminary evidence on metabolic rehabilitation of cancer patients

1 reference

12 December 2020

Phenformin in human obesity

1 reference

12 December 2020

Studies on the antitumoral activity of the biguanides. V

1 reference

12 December 2020

Metabolic immunodepression and metabolic immunotherapy: an attempt of improvement in immunologic response in breast cancer patients by correction of metabolic disturbances

1 reference

12 December 2020

Effect of treatment with phenformin, diphenylhydantoin or L-dopa on life span and tumour incidence in C3H/Sn mice

1 reference

12 December 2020