Protective effects of positive lysosomal modulation in Alzheimer's disease transgenic mouse models (Q28478524)

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5 February 2020

title

Protective effects of positive lysosomal modulation in Alzheimer's disease transgenic mouse models (English)

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6

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author name string

David Butler

1

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Jeannie Hwang

2

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Candice Estick

3

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Akiko Nishiyama

4

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Saranya Santhosh Kumar

5

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Hollie B Young-Oxendine

7

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Meagan L Wisniewski

8

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Ana Charalambides

9

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Ben A Bahr

10

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language of work or name

English

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publication date

10 June 2011

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volume

6

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issue

6

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page(s)

e20501

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Creative Commons Attribution 4.0 International

5 February 2020

copyright license

start time

10 June 2011

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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2 June 2018

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2 June 2018

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2 June 2018

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Inhibitor studies indicate that active cathepsin L is probably essential to its own processing in cultured fibroblasts

2 June 2018

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2 June 2018

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Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

2 June 2018

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Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

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Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway.

21 January 2018

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Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system

21 January 2018

1 reference

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Quantitative decrease in synaptophysin message expression and increase in cathepsin D message expression in Alzheimer disease neurons containing neurofibrillary tangles

21 January 2018

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Detection of a soluble form of BACE-1 in human cerebrospinal fluid by a sensitive activity assay

21 January 2018

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Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities

21 January 2018

1 reference

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Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice.

21 January 2018

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Mechanism mediating oligomeric Aβ clearance by naïve primary microglia

21 January 2018

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Paradoxical effect of leupeptin in vivo on cathepsin B activity.

21 January 2018

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beta-Amyloid precursor protein fragments and lysosomal dense bodies are found in rat brain neurons after ventricular infusion of leupeptin

21 January 2018

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Purification and characterization of hemoglobin-hydrolyzing acidic thiol protease induced by leupeptin in rat liver

21 January 2018

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12 December 2020

Identification of latent procathepsins B and L in microsomal lumen: characterization of enzymatic activation and proteolytic processing in vitro

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12 December 2020

Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, A beta 1-42, in differentiated PC12 cells

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12 December 2020

Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons

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12 December 2020

The neuronal endosomal-lysosomal system in Alzheimer's disease

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12 December 2020

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Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21695208 AND SRC:MED&resulttype=core&format=json

5 February 2020

ADS bibcode

2011PLoSO...620501B

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21695208 AND SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

21695208

2 references