The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure (Q28473586)

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14 January 2020

title

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure (English)

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11

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Yi Zhang

12

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14 January 2020

author name string

Brendan Jones

1

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14 January 2020

Hui Su

2

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Audesh Bhat

3

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Hong Lei

4

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Jeffrey Bajko

5

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Sarah Hevi

6

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Gretchen A Baltus

7

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Shilpa Kadam

8

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Huili Zhai

9

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Reginald Valdez

10

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En Li

13

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Taiping Chen

14

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language of work or name

English

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publication date

12 September 2008

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volume

4

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issue

9

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page(s)

e1000190

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Creative Commons Attribution 4.0 International

14 January 2020

copyright license

start time

12 September 2008

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

1 reference

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Chromatin modifications and their function

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The first molecular details of ALT in human tumor cells

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Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.

19 March 2017

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hDOT1L links histone methylation to leukemogenesis

19 March 2017

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A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

19 March 2017

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Histone H3-K9 methyltransferase ESET is essential for early development

19 March 2017

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Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association

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Translating the Histone Code

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Role for the silencing protein Dot1 in meiotic checkpoint control

19 March 2017

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Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae

19 March 2017

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Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain

19 March 2017

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Partitioning and plasticity of repressive histone methylation states in mammalian chromatin

19 March 2017

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Dot1p modulates silencing in yeast by methylation of the nucleosome core

7 April 2017

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Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability

7 April 2017

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Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination

7 April 2017

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Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L

29 September 2017

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Structural and sequence motifs of protein (histone) methylation enzymes

29 September 2017

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Heterochromatin and tri-methylated lysine 20 of histone H4 in animals

29 September 2017

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Long-range silencing and position effects at telomeres and centromeres: parallels and differences

29 September 2017

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Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b.

29 September 2017

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Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation

29 September 2017

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29 September 2017

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29 September 2017

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Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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27 November 2018

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A core nucleosome surface crucial for transcriptional silencing.

27 November 2018

1 reference

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Efficient integration of short interspersed element-flanked foreign DNA via homologous recombination.

27 November 2018

1 reference

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Selective di- or trimethylation of histone H3 lysine 76 by two DOT1 homologs is important for cell cycle regulation in Trypanosoma brucei

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18787701

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12 December 2020

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Erythropoiesis and vasculogenesis in embryoid bodies lacking visceral yolk sac endoderm

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PubMed

https://pubmed.ncbi.nlm.nih.gov/18787701

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12 December 2020

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Identifiers

DOI

10.1371/JOURNAL.PGEN.1000190

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14 January 2020

Fatcat ID

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24 November 2022

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2 references

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14 January 2020

PubMed publication ID

18787701

2 references