Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite (Q28472957)

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English	Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite	scientific article

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scholarly article

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Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite (English)

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1 reference

based on heuristic

inferred from title

drug metabolism

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based on heuristic

inferred from title

Vijayalakshmi Ravindranath

8

object named as

Vijayalakshmi Ravindranath

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author name string

Varsha Agarwal

1

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Reddy P Kommaddi

2

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Khader Valli

3

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Daniel Ryder

4

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Thomas M Hyde

5

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Joel E Kleinman

6

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Henry W Strobel

7

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language of work or name

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publication date

11 June 2008

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3

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6

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e2337

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copyright license

Creative Commons CC0 License

11 June 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

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Genetic contribution to variable human CYP3A-mediated metabolism

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19 March 2017

Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene

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19 March 2017

cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450

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19 March 2017

Human cytochrome p450 family 4 enzymes: function, genetic variation and regulation

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Effects of genetic polymorphism of cytochrome P450 enzymes on the pharmacokinetics of benzodiazepines

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29 September 2017

Expression and function of cytochrome p450 in brain drug metabolism

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29 September 2017

Cytochrome P450-catalyzed pathways in human brain: metabolism meets pharmacology or old drugs with new mechanism of action?

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29 September 2017

Unique cytochromes P450 in human brain: implication in disease pathogenesis

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29 September 2017

Alprazolam as a probe for CYP3A using a single blood sample: pharmacokinetics of parent drug, and of alpha- and 4-hydroxy metabolites in healthy subjects

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29 September 2017

Differential metabolism of alprazolam by liver and brain cytochrome (P4503A) to pharmacologically active metabolite

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29 September 2017

Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43.

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29 September 2017

Cytochrome P-450 3A4: regulation and role in drug metabolism

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An improved, rapid Northern protocol.

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Clinical pharmacokinetics of alprazolam. Therapeutic implications

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Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta

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A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples

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Determination of biological activity of alprazolam, triazolam and their metabolites

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2 June 2018

Rat brain cytochromes P-450: catalytic, immunochemical properties and inducibility of multiple forms

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21 January 2018

Xenobiotic metabolism in human brain--presence of cytochrome P-450 and associated mono-oxygenases

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An alternatively spliced cytochrome P4501A1 in human brain fails to bioactivate polycyclic aromatic hydrocarbons to DNA-reactive metabolites

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21 January 2018

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

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21 January 2018

In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans

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Effect of CYP3A5*3 genotype on the pharmacokinetics and pharmacodynamics of alprazolam in healthy subjects.

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21 January 2018

Constitutive expression and localization of the major drug metabolizing enzyme, cytochrome P4502D in human brain

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21 January 2018

Estrogen regulation of the cytochrome P450 3A subfamily in humans

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21 January 2018

Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method

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CYP3A5 polymorphism and alprazolam pharmacokinetics/pharmacodynamics

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12 December 2020

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10.1371/JOURNAL.PONE.0002337

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2008PLoSO...3.2337A

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