PI3K at the crossroads of tumor angiogenesis signaling pathways (Q28396795)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27308431 AND SRC:MED&resulttype=core&format=json

14 March 2020

review article

1 reference

title

PI3K at the crossroads of tumor angiogenesis signaling pathways (English)

1 reference

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14 March 2020

1 reference

1 reference

2

1 reference

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14 March 2020

author name string

Adriana Soler

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27308431 AND SRC:MED&resulttype=core&format=json

14 March 2020

Mariona Graupera

series ordinal

3

1 reference

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14 March 2020

language of work or name

English

0 references

publication date

26 February 2015

2 references

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Molecular & cellular oncology

14 March 2020

published in

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14 March 2020

volume

2

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14 March 2020

issue

2

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14 March 2020

page(s)

e975624

1 reference

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Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

14 March 2020

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Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor

19 March 2017

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Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

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Should individual PI3 kinase isoforms be targeted in cancer?

19 March 2017

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miR-126 regulates angiogenic signaling and vascular integrity

19 March 2017

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19 March 2017

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PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis

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The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

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The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex

19 March 2017

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The phosphoinositide 3-kinase pathway

19 March 2017

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Tumor angiogenesis: therapeutic implications

19 March 2017

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Molecular mechanisms and clinical applications of angiogenesis

19 March 2017

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Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

7 April 2017

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Basic and Therapeutic Aspects of Angiogenesis

7 April 2017

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Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis

7 April 2017

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Molecular regulation of angiogenesis and lymphangiogenesis

7 April 2017

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Angiogenesis in health and disease

7 April 2017

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The emerging mechanisms of isoform-specific PI3K signalling

7 April 2017

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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

7 April 2017

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PI3K and cancer: lessons, challenges and opportunities

7 April 2017

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Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates

24 May 2017

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Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor

29 September 2017

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RAS interaction with PI3K p110α is required for tumor-induced angiogenesis.

29 September 2017

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Stand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer

29 September 2017

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Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial

29 September 2017

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29 September 2017

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Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer

29 September 2017

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NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity

29 September 2017

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Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway

29 September 2017

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Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors

29 September 2017

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Modulation of the Tumor Microvasculature by Phosphoinositide-3 Kinase Inhibition Increases Doxorubicin Delivery In Vivo

29 September 2017

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29 September 2017

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29 September 2017

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Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.

29 September 2017

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29 September 2017

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29 September 2017

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Reduced VEGF Production, Angiogenesis, and Vascular Regrowth Contribute to the Antitumor Properties of Dual mTORC1/mTORC2 Inhibitors

29 September 2017

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The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Class 1A PI3K regulates vessel integrity during development and tumorigenesis

29 September 2017

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The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.

29 September 2017

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29 September 2017

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29 September 2017

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Phosphatidylinositol 3-kinase mediates angiogenesis and vascular permeability associated with ovarian carcinoma

29 September 2017

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Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling

29 September 2017

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Angiopoietin 1, PDGF-B, and TGF-beta gene regulation in endothelial cell and smooth muscle cell interaction

29 September 2017

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Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

29 September 2017

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Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

29 September 2017

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p70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation

29 September 2017

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29 September 2017

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Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

29 September 2017

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Phosphoinositide 3-kinase gamma gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions

2 June 2018

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Pericytes limit tumor cell metastasis

2 June 2018

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Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis

2 June 2018

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2 June 2018

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21 January 2018

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PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis

21 January 2018

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Platelet-Derived Growth Factor-BB, Insulin-like Growth Factor-I, and Phorbol Ester Activate Different Signaling Pathways for Stimulation of Vascular Smooth Muscle Cell Migration

21 January 2018

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Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging

21 January 2018

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Antiangiogenic effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor.

21 January 2018

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Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

21 January 2018

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Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function.

21 January 2018

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Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element

21 January 2018

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27 November 2018

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12 December 2020

Dual Inhibition of the PI3K/mTOR Pathway Increases Tumor Radiosensitivity by Normalizing Tumor Vasculature

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Platelet-derived growth factor-BB (PDGF-BB) regulation of migration and focal adhesion kinase phosphorylation in rabbit aortic vascular smooth muscle cells: roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinases

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12 December 2020

Deletion of the p110 isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

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12 December 2020

SnapShot: Tumor angiogenesis

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Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27308431 AND SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27308431 AND SRC:MED&resulttype=core&format=json

14 March 2020

PubMed publication ID

27308431

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27308431 AND SRC:MED&resulttype=core&format=json